{
  "url": "https://dantelabs.com/el/genes/thpo",
  "gene": {
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    "symbol": "THPO",
    "name": "thrombopoietin",
    "hgnc": "HGNC:11795",
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    "location": "3q27.1",
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      "MPLLG"
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      "MGDF"
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    "omim": [
      "600044"
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    "uniprot": [
      "P40225"
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      "release": "v1.5",
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      "strand": "-",
      "ensemblTranscript": "ENST00000647395.1",
      "refseqTranscript": "NM_000460.4",
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      "refseqProtein": "NP_000451.1",
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        },
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        }
      ],
      "cds": {
        "start": 184372513,
        "end": 184376259
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "3",
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      "end": 184095932,
      "strand": "-"
    },
    "neighbourhood": {
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      "end": 184875070,
      "genes": [
        {
          "symbol": "",
          "ensemblId": "ENSG00000283765",
          "biotype": "protein_coding",
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          "end": 183884889,
          "strand": "-"
        },
        {
          "symbol": "PARL",
          "ensemblId": "ENSG00000175193",
          "biotype": "protein_coding",
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          "strand": "-",
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        {
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          "end": 184018307,
          "strand": "-",
          "slug": "abcc5"
        },
        {
          "symbol": "HTR3D",
          "ensemblId": "ENSG00000186090",
          "biotype": "protein_coding",
          "start": 184031544,
          "end": 184039369,
          "strand": "+",
          "slug": "htr3d"
        },
        {
          "symbol": "HTR3C",
          "ensemblId": "ENSG00000178084",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "htr3c"
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        {
          "symbol": "HTR3E",
          "ensemblId": "ENSG00000186038",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "htr3e"
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        {
          "symbol": "EIF2B5",
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          "biotype": "protein_coding",
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          "end": 184146127,
          "strand": "+",
          "slug": "eif2b5"
        },
        {
          "symbol": "DVL3",
          "ensemblId": "ENSG00000161202",
          "biotype": "protein_coding",
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          "strand": "+",
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        },
        {
          "symbol": "AP2M1",
          "ensemblId": "ENSG00000161203",
          "biotype": "protein_coding",
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          "strand": "+",
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        {
          "symbol": "ABCF3",
          "ensemblId": "ENSG00000161204",
          "biotype": "protein_coding",
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          "end": 184194451,
          "strand": "+",
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        {
          "symbol": "VWA5B2",
          "ensemblId": "ENSG00000145198",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "ALG3",
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          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "alg3"
        },
        {
          "symbol": "EEF1AKMT4",
          "ensemblId": "ENSG00000284753",
          "biotype": "protein_coding",
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          "end": 184258759,
          "strand": "+",
          "slug": "eef1akmt4"
        },
        {
          "symbol": "EEF1AKMT4-ECE2",
          "ensemblId": "ENSG00000284917",
          "biotype": "protein_coding",
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        {
          "symbol": "CAMK2N2",
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          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "camk2n2"
        },
        {
          "symbol": "ECE2",
          "ensemblId": "ENSG00000145194",
          "biotype": "protein_coding",
          "start": 184275531,
          "end": 184293031,
          "strand": "+",
          "slug": "ece2"
        },
        {
          "symbol": "PSMD2",
          "ensemblId": "ENSG00000175166",
          "biotype": "protein_coding",
          "start": 184299157,
          "end": 184309054,
          "strand": "+",
          "slug": "psmd2"
        },
        {
          "symbol": "EIF4G1",
          "ensemblId": "ENSG00000114867",
          "biotype": "protein_coding",
          "start": 184314490,
          "end": 184335358,
          "strand": "+",
          "slug": "eif4g1"
        },
        {
          "symbol": "FAM131A",
          "ensemblId": "ENSG00000175182",
          "biotype": "protein_coding",
          "start": 184335916,
          "end": 184348421,
          "strand": "+",
          "slug": "fam131a"
        },
        {
          "symbol": "CLCN2",
          "ensemblId": "ENSG00000114859",
          "biotype": "protein_coding",
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          "end": 184363274,
          "strand": "-",
          "slug": "clcn2"
        },
        {
          "symbol": "POLR2H",
          "ensemblId": "ENSG00000163882",
          "biotype": "protein_coding",
          "start": 184360856,
          "end": 184368596,
          "strand": "+",
          "slug": "polr2h"
        },
        {
          "symbol": "CHRD",
          "ensemblId": "ENSG00000090539",
          "biotype": "protein_coding",
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          "end": 184390736,
          "strand": "+",
          "slug": "chrd"
        },
        {
          "symbol": "EPHB3",
          "ensemblId": "ENSG00000182580",
          "biotype": "protein_coding",
          "start": 184561751,
          "end": 184582408,
          "strand": "+",
          "slug": "ephb3"
        },
        {
          "symbol": "MAGEF1",
          "ensemblId": "ENSG00000177383",
          "biotype": "protein_coding",
          "start": 184708749,
          "end": 184712073,
          "strand": "-",
          "slug": "magef1"
        },
        {
          "symbol": "VPS8",
          "ensemblId": "ENSG00000156931",
          "biotype": "protein_coding",
          "start": 184812113,
          "end": 185054009,
          "strand": "+",
          "slug": "vps8"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "inherited-thrombocytopenias",
        "name": "Κληρονομικές θρομβοκυτταροπενίες",
        "diseases": [
          {
            "mondoId": "MONDO:0100241",
            "name": "Κληρονομική θρομβοκυτταροπενία",
            "genes": 33,
            "inheritance": null,
            "description": "Μια ομάδα παθήσεων που προκαλούν χαμηλό αριθμό αιμοπεταλίων για όλη τη ζωή, συνδεδεμένες με γονίδια όπως τα MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 και MECOM, και κληρονομούνται με επικρατή, υπολειπόμενο ή συνδεδεμένο με το X χρωμόσωμα τρόπο.",
            "management": "Μια γενετική διάγνωση αποτρέπει τη λανθασμένη διάγνωση ως ανοσολογική θρομβοκυτταροπενία, με περιττές κορτικοστεροειδείς θεραπείες ή αφαίρεση του σπληνός, και καθοδηγεί την παρακολούθηση για σχετικά προβλήματα των νεφρών, της ακοής ή του αίματος.",
            "evidence": {
              "gencc": [
                "ClinGen",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/inherited-thrombocytopenias"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "acute-myeloid-leukemia",
        "name": "Acute myeloid leukemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/acute-myeloid-leukemia"
      },
      {
        "slug": "aplastic-anemia",
        "name": "Aplastic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/aplastic-anemia"
      },
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      },
      {
        "slug": "arterial-thrombosis",
        "name": "Blood clot in artery",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/arterial-thrombosis"
      },
      {
        "slug": "venous-thrombosis",
        "name": "Blood clot in vein",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/venous-thrombosis"
      },
      {
        "slug": "bone-marrow-hypocellularity",
        "name": "Bone marrow failure",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bone-marrow-hypocellularity"
      },
      {
        "slug": "chest-pain",
        "name": "Chest pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chest-pain"
      },
      {
        "slug": "chronic-myelogenous-leukemia",
        "name": "Chronic myelogenous leukemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/chronic-myelogenous-leukemia"
      },
      {
        "slug": "decreased-circulating-thrombopoietin-concentration",
        "name": "Decreased circulating thrombopoietin concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-thrombopoietin-concentration"
      },
      {
        "slug": "dysarthria",
        "name": "Difficulty articulating speech",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dysarthria"
      },
      {
        "slug": "cerebral-ischemia",
        "name": "Disruption of blood oxygen supply to brain",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cerebral-ischemia"
      },
      {
        "slug": "vertigo",
        "name": "Dizziness",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/vertigo"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "hyperhidrosis",
        "name": "Excessive sweating",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperhidrosis"
      },
      {
        "slug": "syncope",
        "name": "Fainting spell",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/syncope"
      },
      {
        "slug": "headache",
        "name": "Headache",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/headache"
      },
      {
        "slug": "impaired-adp-induced-platelet-aggregation",
        "name": "Impaired ADP-induced platelet aggregation",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/impaired-adp-induced-platelet-aggregation"
      },
      {
        "slug": "impaired-collagen-induced-platelet-aggregation",
        "name": "Impaired collagen-induced platelet aggregation",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/impaired-collagen-induced-platelet-aggregation"
      },
      {
        "slug": "impaired-epinephrine-induced-platelet-aggregation",
        "name": "Impaired epinephrine-induced platelet aggregation",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/impaired-epinephrine-induced-platelet-aggregation"
      },
      {
        "slug": "pulmonary-arterial-hypertension",
        "name": "Increased blood pressure in blood vessels of lungs",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pulmonary-arterial-hypertension"
      },
      {
        "slug": "thrombocytosis",
        "name": "Increased number of platelets in blood",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/thrombocytosis"
      },
      {
        "slug": "splenomegaly",
        "name": "Increased spleen size",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/splenomegaly"
      },
      {
        "slug": "pruritus",
        "name": "Itching",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pruritus"
      },
      {
        "slug": "pancytopenia",
        "name": "Low blood cell count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pancytopenia"
      },
      {
        "slug": "decreased-total-neutrophil-count",
        "name": "Low blood neutrophil count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-total-neutrophil-count"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "thrombocytopenia",
        "name": "Low platelet count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/thrombocytopenia"
      },
      {
        "slug": "transient-ischemic-attack",
        "name": "Mini stroke",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/transient-ischemic-attack"
      },
      {
        "slug": "myelodysplasia",
        "name": "Myelodysplasia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myelodysplasia"
      },
      {
        "slug": "visual-field-defect",
        "name": "Partial loss of field of vision",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/visual-field-defect"
      },
      {
        "slug": "peripheral-arterial-stenosis",
        "name": "Peripheral arterial stenosis",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/peripheral-arterial-stenosis"
      },
      {
        "slug": "paresthesia",
        "name": "Pins and needles feeling",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/paresthesia"
      },
      {
        "slug": "weight-loss",
        "name": "Weight loss",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/weight-loss"
      }
    ],
    "related": [
      {
        "slug": "actb",
        "symbol": "ACTB",
        "name": "actin beta",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/actb"
      },
      {
        "slug": "actn1",
        "symbol": "ACTN1",
        "name": "actinin alpha 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/actn1"
      },
      {
        "slug": "adamts13",
        "symbol": "ADAMTS13",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 13",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/adamts13"
      },
      {
        "slug": "ankrd26",
        "symbol": "ANKRD26",
        "name": "ankyrin repeat domain 26",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/ankrd26"
      },
      {
        "slug": "arpc1b",
        "symbol": "ARPC1B",
        "name": "actin related protein 2/3 complex subunit 1B",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/arpc1b"
      },
      {
        "slug": "cdc42",
        "symbol": "CDC42",
        "name": "cell division cycle 42",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/cdc42"
      },
      {
        "slug": "cycs",
        "symbol": "CYCS",
        "name": "cytochrome c, somatic",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/cycs"
      },
      {
        "slug": "diaph1",
        "symbol": "DIAPH1",
        "name": "diaphanous related formin 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/diaph1"
      },
      {
        "slug": "etv6",
        "symbol": "ETV6",
        "name": "ETS variant transcription factor 6",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/etv6"
      },
      {
        "slug": "fli1",
        "symbol": "FLI1",
        "name": "Fli-1 proto-oncogene, ETS transcription factor",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/fli1"
      },
      {
        "slug": "fyb1",
        "symbol": "FYB1",
        "name": "FYN binding protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/fyb1"
      },
      {
        "slug": "gale",
        "symbol": "GALE",
        "name": "UDP-galactose-4-epimerase",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/gale"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}