{
  "url": "https://dantelabs.com/el/genes/stx16",
  "gene": {
    "slug": "stx16",
    "symbol": "STX16",
    "name": "syntaxin 16",
    "hgnc": "HGNC:11431",
    "summary": null,
    "location": "20q13.32",
    "locusType": "gene with protein product",
    "aliases": [
      "hsyn16",
      "SYN16",
      "SYN-16"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000124222",
    "entrezId": 8675,
    "omim": [
      "603666"
    ],
    "uniprot": [
      "O14662"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "20",
      "start": 58651283,
      "end": 58679526,
      "strand": "+",
      "ensemblTranscript": "ENST00000371141.8",
      "refseqTranscript": "NM_001001433.3",
      "ensemblProtein": "ENSP00000360183.4",
      "refseqProtein": "NP_001001433.1",
      "exons": [
        {
          "start": 58651283,
          "end": 58652138
        },
        {
          "start": 58659623,
          "end": 58659634
        },
        {
          "start": 58667490,
          "end": 58667597
        },
        {
          "start": 58667987,
          "end": 58668127
        },
        {
          "start": 58669291,
          "end": 58669453
        },
        {
          "start": 58670512,
          "end": 58670603
        },
        {
          "start": 58671154,
          "end": 58671297
        },
        {
          "start": 58673631,
          "end": 58673711
        },
        {
          "start": 58676187,
          "end": 58679526
        }
      ],
      "cds": {
        "start": 58652007,
        "end": 58676291
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "20",
      "start": 57226328,
      "end": 57254582,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 58165405,
      "end": 59165404,
      "genes": [
        {
          "symbol": "ANKRD60",
          "ensemblId": "ENSG00000124227",
          "biotype": "protein_coding",
          "start": 58216126,
          "end": 58228653,
          "strand": "-",
          "slug": "ankrd60"
        },
        {
          "symbol": "RAB22A",
          "ensemblId": "ENSG00000124209",
          "biotype": "protein_coding",
          "start": 58309706,
          "end": 58367507,
          "strand": "+",
          "slug": "rab22a"
        },
        {
          "symbol": "VAPB",
          "ensemblId": "ENSG00000124164",
          "biotype": "protein_coding",
          "start": 58389114,
          "end": 58451101,
          "strand": "+",
          "slug": "vapb"
        },
        {
          "symbol": "APCDD1L",
          "ensemblId": "ENSG00000198768",
          "biotype": "protein_coding",
          "start": 58457632,
          "end": 58515399,
          "strand": "-",
          "slug": "apcdd1l"
        },
        {
          "symbol": "STX16-NPEPL1",
          "ensemblId": "ENSG00000254995",
          "biotype": "protein_coding",
          "start": 58651434,
          "end": 58715410,
          "strand": "+",
          "slug": "stx16-npepl1"
        },
        {
          "symbol": "NPEPL1",
          "ensemblId": "ENSG00000215440",
          "biotype": "protein_coding",
          "start": 58689125,
          "end": 58719238,
          "strand": "+",
          "slug": "npepl1"
        },
        {
          "symbol": "GNAS",
          "ensemblId": "ENSG00000087460",
          "biotype": "protein_coding",
          "start": 58839669,
          "end": 58911192,
          "strand": "+",
          "slug": "gnas"
        },
        {
          "symbol": "NELFCD",
          "ensemblId": "ENSG00000101158",
          "biotype": "protein_coding",
          "start": 58981203,
          "end": 58997184,
          "strand": "+",
          "slug": "nelfcd"
        },
        {
          "symbol": "CTSZ",
          "ensemblId": "ENSG00000101160",
          "biotype": "protein_coding",
          "start": 58985686,
          "end": 59008238,
          "strand": "-",
          "slug": "ctsz"
        },
        {
          "symbol": "TUBB1",
          "ensemblId": "ENSG00000101162",
          "biotype": "protein_coding",
          "start": 59019379,
          "end": 59026654,
          "strand": "+",
          "slug": "tubb1"
        },
        {
          "symbol": "ATP5F1E",
          "ensemblId": "ENSG00000124172",
          "biotype": "protein_coding",
          "start": 59025475,
          "end": 59032363,
          "strand": "-",
          "slug": "atp5f1e"
        },
        {
          "symbol": "PRELID3B",
          "ensemblId": "ENSG00000101166",
          "biotype": "protein_coding",
          "start": 59033092,
          "end": 59042897,
          "strand": "-",
          "slug": "prelid3b"
        },
        {
          "symbol": "ZNF831",
          "ensemblId": "ENSG00000124203",
          "biotype": "protein_coding",
          "start": 59123381,
          "end": 59259113,
          "strand": "+",
          "slug": "znf831"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "pseudohypoparathyroidism-gnas-inactivation-disorders",
        "name": "Ψευδοϋποπαραθυρεοειδισμός και διαταραχές απενεργοποίησης του GNAS",
        "diseases": [
          {
            "mondoId": "MONDO:0019992",
            "name": "Ψευδοϋποπαραθυρεοειδισμός",
            "genes": 2,
            "inheritance": "autosomal-dominant",
            "description": "Αντίσταση στην παραθυρεοειδική ορμόνη, και συχνά στην TSH και σε άλλες ορμόνες, που προκαλεί χαμηλό ασβέστιο και υψηλό φωσφορικό, με ή χωρίς κληρονομική οστεοδυστροφία Albright.",
            "management": "Η καλσιτριόλη, το ασβέστιο και, όπου χρειάζεται, η λεβοθυροξίνη ή η αυξητική ορμόνη αντιμετωπίζουν την αντίσταση στις ορμόνες.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0800466",
            "name": "Διαταραχή απενεργοποίησης του GNAS",
            "genes": 2,
            "inheritance": "autosomal-dominant",
            "description": "Παθήσεις που προκαλούνται από απώλεια της λειτουργίας του GNAS, συμπεριλαμβανομένων του ψευδο-ψευδοϋποπαραθυρεοειδισμού και της προοδευτικής οστικής ετεροπλασίας· η μορφή που αναπτύσσεται εξαρτάται από το ποιος γονέας μετέδωσε τη μεταβολή.",
            "management": null,
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/pseudohypoparathyroidism-gnas-inactivation-disorders"
      },
      {
        "slug": "thyroid-cancer-report",
        "name": "Καρκίνος του θυρεοειδούς",
        "diseases": [
          {
            "mondoId": "MONDO:0001223",
            "name": "Διαταραχή του παραθυρεοειδούς αδένα",
            "genes": 10,
            "inheritance": null,
            "description": "Νόσος που αφορά τον παραθυρεοειδή αδένα.",
            "management": null,
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/thyroid-cancer-report"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-symptom",
        "name": "Abdominal symptom",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abdominal-symptom"
      },
      {
        "slug": "anxiety",
        "name": "Anxiety",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anxiety"
      },
      {
        "slug": "autoimmune-antibody-positivity",
        "name": "Autoimmune antibody positivity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/autoimmune-antibody-positivity"
      },
      {
        "slug": "dyspnea",
        "name": "Breathing difficulty",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dyspnea"
      },
      {
        "slug": "calcinosis",
        "name": "Calcium buildup in soft tissues of body",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/calcinosis"
      },
      {
        "slug": "chest-pain",
        "name": "Chest pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/chest-pain"
      },
      {
        "slug": "cataract",
        "name": "Clouding of the lens of the eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cataract"
      },
      {
        "slug": "cortical-subperiosteal-resorption-of-humeral-metaphyses",
        "name": "Cortical subperiosteal resorption of humeral metaphyses",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cortical-subperiosteal-resorption-of-humeral-metaphyses"
      },
      {
        "slug": "hyporeflexia",
        "name": "Decreased reflex response",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hyporeflexia"
      },
      {
        "slug": "decreased-response-to-growth-hormone-stimulation-test",
        "name": "Decreased response to growth hormone stimulation test",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/decreased-response-to-growth-hormone-stimulation-test"
      },
      {
        "slug": "delayed-eruption-of-teeth",
        "name": "Delayed eruption of teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-eruption-of-teeth"
      },
      {
        "slug": "depressed-nasal-bridge",
        "name": "Depressed nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/depressed-nasal-bridge"
      },
      {
        "slug": "depression",
        "name": "Depression",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/depression"
      },
      {
        "slug": "dyskinesia",
        "name": "Disorder of involuntary muscle movements",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dyskinesia"
      },
      {
        "slug": "ectopic-calcification",
        "name": "Ectopic calcification",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/ectopic-calcification"
      },
      {
        "slug": "elevated-circulating-parathyroid-hormone-level",
        "name": "Elevated circulating parathyroid hormone level",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/elevated-circulating-parathyroid-hormone-level"
      },
      {
        "slug": "full-cheeks",
        "name": "Full cheeks",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/full-cheeks"
      },
      {
        "slug": "hyperphosphatemia",
        "name": "High blood phosphate levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hyperphosphatemia"
      },
      {
        "slug": "hypocalcemic-tetany",
        "name": "Hypocalcemic tetany",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypocalcemic-tetany"
      },
      {
        "slug": "diaphyseal-sclerosis",
        "name": "Increased bone density in shaft of long bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/diaphyseal-sclerosis"
      },
      {
        "slug": "increased-bone-density-with-cystic-changes",
        "name": "Increased bone density with cystic changes",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/increased-bone-density-with-cystic-changes"
      },
      {
        "slug": "increased-bone-mineral-density",
        "name": "Increased bone mineral density",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/increased-bone-mineral-density"
      },
      {
        "slug": "nystagmus",
        "name": "Involuntary, rapid, rhythmic eye movements",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/nystagmus"
      },
      {
        "slug": "irritability",
        "name": "Irritability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/irritability"
      },
      {
        "slug": "laryngeal-dystonia",
        "name": "Laryngeal dystonia",
        "systems": [
          "abnormality-of-the-nervous-system",
          "abnormality-of-the-voice"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/laryngeal-dystonia"
      },
      {
        "slug": "hypocalcemia",
        "name": "Low blood calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypocalcemia"
      },
      {
        "slug": "hypocalcemic-seizures",
        "name": "Low calcium seizures",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hypocalcemic-seizures"
      },
      {
        "slug": "low-urinary-cyclic-amp-response-to-pth-administration",
        "name": "Low urinary cyclic AMP response to PTH administration",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/low-urinary-cyclic-amp-response-to-pth-administration"
      },
      {
        "slug": "muscle-spasm",
        "name": "Muscle spasm",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/muscle-spasm"
      },
      {
        "slug": "myoclonic-spasms",
        "name": "Myoclonic spasms",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myoclonic-spasms"
      },
      {
        "slug": "obesity",
        "name": "Obesity",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/obesity"
      },
      {
        "slug": "conjunctivitis",
        "name": "Pink eye",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-eye",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/conjunctivitis"
      },
      {
        "slug": "paresthesia",
        "name": "Pins and needles feeling",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/paresthesia"
      },
      {
        "slug": "pituitary-resistance-to-thyroid-hormone",
        "name": "Pituitary resistance to thyroid hormone",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/pituitary-resistance-to-thyroid-hormone"
      },
      {
        "slug": "prolonged-qt-interval",
        "name": "Prolonged QT interval",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prolonged-qt-interval"
      },
      {
        "slug": "pseudohypoparathyroidism",
        "name": "Pseudohypoparathyroidism",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pseudohypoparathyroidism"
      },
      {
        "slug": "round-face",
        "name": "Round face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/round-face"
      },
      {
        "slug": "brachydactyly",
        "name": "Short fingers or toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/brachydactyly"
      },
      {
        "slug": "short-neck",
        "name": "Short neck",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-neck"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "short-metacarpal",
        "name": "Shortened long bone of hand",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/short-metacarpal"
      },
      {
        "slug": "enamel-hypoplasia",
        "name": "Thin dental enamel",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/enamel-hypoplasia"
      }
    ],
    "related": [
      {
        "slug": "gnas",
        "symbol": "GNAS",
        "name": "GNAS complex locus",
        "shared": 3,
        "url": "https://dantelabs.com/el/genes/gnas"
      },
      {
        "slug": "aire",
        "symbol": "AIRE",
        "name": "autoimmune regulator",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/aire"
      },
      {
        "slug": "casr",
        "symbol": "CASR",
        "name": "calcium sensing receptor",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/casr"
      },
      {
        "slug": "cdc73",
        "symbol": "CDC73",
        "name": "cell division cycle 73",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/cdc73"
      },
      {
        "slug": "gcm2",
        "symbol": "GCM2",
        "name": "GCM transcription factor 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/gcm2"
      },
      {
        "slug": "gna11",
        "symbol": "GNA11",
        "name": "G protein subunit alpha 11",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/gna11"
      },
      {
        "slug": "men1",
        "symbol": "MEN1",
        "name": "menin 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/men1"
      },
      {
        "slug": "pth",
        "symbol": "PTH",
        "name": "parathyroid hormone",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/pth"
      },
      {
        "slug": "trpv6",
        "symbol": "TRPV6",
        "name": "transient receptor potential cation channel subfamily V member 6",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/trpv6"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}