{
  "url": "https://dantelabs.com/el/genes/slitrk6",
  "gene": {
    "slug": "slitrk6",
    "symbol": "SLITRK6",
    "name": "SLIT and NTRK like family member 6",
    "hgnc": "HGNC:23503",
    "summary": null,
    "location": "13q31.1",
    "locusType": "gene with protein product",
    "aliases": [
      "FLJ22774"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000184564",
    "entrezId": 84189,
    "omim": [
      "609681"
    ],
    "uniprot": [
      "Q9H5Y7"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "13",
      "start": 85792790,
      "end": 85799419,
      "strand": "-",
      "ensemblTranscript": "ENST00000647374.2",
      "refseqTranscript": "NM_032229.3",
      "ensemblProtein": "ENSP00000495507.1",
      "refseqProtein": "NP_115605.2",
      "exons": [
        {
          "start": 85792790,
          "end": 85796532
        },
        {
          "start": 85798914,
          "end": 85799419
        }
      ],
      "cds": {
        "start": 85793983,
        "end": 85796508
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "13",
      "start": 86366925,
      "end": 86373623,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 85296105,
      "end": 86296104,
      "genes": [],
      "truncated": false
    },
    "reports": [
      {
        "slug": "high-myopia-sensorineural-deafness-slitrk6",
        "name": "Υψηλή μυωπία με νευροαισθητήρια κώφωση",
        "diseases": [
          {
            "mondoId": "MONDO:0009082",
            "name": "Σύνδρομο υψηλής μυωπίας και νευροαισθητήριας κώφωσης",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Οφείλεται σε αλλαγές και στα δύο αντίγραφα του SLITRK6, το οποίο συμβάλλει στο σχηματισμό νευρικών συνάψεων στο έσω αυτί και επηρεάζει την ανάπτυξη του οφθαλμού. Έχει αναφερθεί σε διάφορους πληθυσμούς.",
            "management": "Η έγκαιρη εξέταση της ακοής καθοδηγεί την χρήση ακουστικών βαρηκοΐας ή κοχλιακών εμφυτευμάτων και την υποστήριξη επικοινωνίας· τα γυαλιά ή οι φακοί επαφής διορθώνουν τη μυωπία, ενώ οι τακτικοί οφθαλμολογικοί έλεγχοι παρακολουθούν τυχόν επιπλοκές της υψηλής μυωπίας. Οι γονείς είναι συνήθως φορείς, επομένως είναι διαθέσιμος έλεγχος φορείας για συγγενείς και γενετική συμβουλευτική.",
            "evidence": {
              "gencc": [
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/high-myopia-sensorineural-deafness-slitrk6"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "high-myopia",
        "name": "Severe near sightedness",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/high-myopia"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.19-9814e911",
      "panel": "2026-10-19",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}