{
  "url": "https://dantelabs.com/el/genes/serpinf2",
  "gene": {
    "slug": "serpinf2",
    "symbol": "SERPINF2",
    "name": "serpin family F member 2",
    "hgnc": "HGNC:9075",
    "summary": null,
    "location": "17p13.3",
    "locusType": "gene with protein product",
    "aliases": [
      "API",
      "ALPHA-2-PI",
      "A2AP",
      "AAP",
      "alpha2AP"
    ],
    "previousSymbols": [
      "PLI"
    ],
    "ensemblId": "ENSG00000167711",
    "entrezId": 5345,
    "omim": [
      "613168"
    ],
    "uniprot": [
      "P08697"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "17",
      "start": 1742871,
      "end": 1755265,
      "strand": "+",
      "ensemblTranscript": "ENST00000453066.6",
      "refseqTranscript": "NM_000934.4",
      "ensemblProtein": "ENSP00000402286.2",
      "refseqProtein": "NP_000925.2",
      "exons": [
        {
          "start": 1742871,
          "end": 1742908
        },
        {
          "start": 1744992,
          "end": 1745058
        },
        {
          "start": 1745175,
          "end": 1745213
        },
        {
          "start": 1745333,
          "end": 1745395
        },
        {
          "start": 1745708,
          "end": 1745909
        },
        {
          "start": 1747019,
          "end": 1747162
        },
        {
          "start": 1747309,
          "end": 1747512
        },
        {
          "start": 1748598,
          "end": 1748740
        },
        {
          "start": 1752586,
          "end": 1752790
        },
        {
          "start": 1754122,
          "end": 1755265
        }
      ],
      "cds": {
        "start": 1744996,
        "end": 1754534
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "17",
      "start": 1646130,
      "end": 1658562,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 1249068,
      "end": 2249067,
      "genes": [
        {
          "symbol": "BHLHA9",
          "ensemblId": "ENSG00000205899",
          "biotype": "protein_coding",
          "start": 1270444,
          "end": 1271815,
          "strand": "+",
          "slug": "bhlha9"
        },
        {
          "symbol": "TRARG1",
          "ensemblId": "ENSG00000184811",
          "biotype": "protein_coding",
          "start": 1279554,
          "end": 1300978,
          "strand": "+",
          "slug": "trarg1"
        },
        {
          "symbol": "YWHAE",
          "ensemblId": "ENSG00000108953",
          "biotype": "protein_coding",
          "start": 1344275,
          "end": 1400326,
          "strand": "-",
          "slug": "ywhae"
        },
        {
          "symbol": "CRK",
          "ensemblId": "ENSG00000167193",
          "biotype": "protein_coding",
          "start": 1420689,
          "end": 1463162,
          "strand": "-",
          "slug": "crk"
        },
        {
          "symbol": "MYO1C",
          "ensemblId": "ENSG00000197879",
          "biotype": "protein_coding",
          "start": 1464186,
          "end": 1492707,
          "strand": "-",
          "slug": "myo1c"
        },
        {
          "symbol": "INPP5K",
          "ensemblId": "ENSG00000132376",
          "biotype": "protein_coding",
          "start": 1494571,
          "end": 1516759,
          "strand": "-",
          "slug": "inpp5k"
        },
        {
          "symbol": "PITPNA",
          "ensemblId": "ENSG00000174238",
          "biotype": "protein_coding",
          "start": 1517718,
          "end": 1562861,
          "strand": "-",
          "slug": "pitpna"
        },
        {
          "symbol": "SLC43A2",
          "ensemblId": "ENSG00000167703",
          "biotype": "protein_coding",
          "start": 1569268,
          "end": 1630103,
          "strand": "-",
          "slug": "slc43a2"
        },
        {
          "symbol": "SCARF1",
          "ensemblId": "ENSG00000074660",
          "biotype": "protein_coding",
          "start": 1633848,
          "end": 1646122,
          "strand": "-",
          "slug": "scarf1"
        },
        {
          "symbol": "RILP",
          "ensemblId": "ENSG00000167705",
          "biotype": "protein_coding",
          "start": 1646138,
          "end": 1650083,
          "strand": "-",
          "slug": "rilp"
        },
        {
          "symbol": "PRPF8",
          "ensemblId": "ENSG00000174231",
          "biotype": "protein_coding",
          "start": 1650624,
          "end": 1684909,
          "strand": "-",
          "slug": "prpf8"
        },
        {
          "symbol": "TLCD2",
          "ensemblId": "ENSG00000185561",
          "biotype": "protein_coding",
          "start": 1688598,
          "end": 1710639,
          "strand": "-",
          "slug": "tlcd2"
        },
        {
          "symbol": "WDR81",
          "ensemblId": "ENSG00000167716",
          "biotype": "protein_coding",
          "start": 1716523,
          "end": 1738599,
          "strand": "+",
          "slug": "wdr81"
        },
        {
          "symbol": "SERPINF1",
          "ensemblId": "ENSG00000132386",
          "biotype": "protein_coding",
          "start": 1761958,
          "end": 1777627,
          "strand": "+",
          "slug": "serpinf1"
        },
        {
          "symbol": "SMYD4",
          "ensemblId": "ENSG00000186532",
          "biotype": "protein_coding",
          "start": 1779485,
          "end": 1830634,
          "strand": "-",
          "slug": "smyd4"
        },
        {
          "symbol": "RPA1",
          "ensemblId": "ENSG00000132383",
          "biotype": "protein_coding",
          "start": 1829702,
          "end": 1900082,
          "strand": "+",
          "slug": "rpa1"
        },
        {
          "symbol": "RTN4RL1",
          "ensemblId": "ENSG00000185924",
          "biotype": "protein_coding",
          "start": 1934677,
          "end": 2025355,
          "strand": "-",
          "slug": "rtn4rl1"
        },
        {
          "symbol": "DPH1",
          "ensemblId": "ENSG00000108963",
          "biotype": "protein_coding",
          "start": 2030136,
          "end": 2043898,
          "strand": "+",
          "slug": "dph1"
        },
        {
          "symbol": "OVCA2",
          "ensemblId": "ENSG00000262664",
          "biotype": "protein_coding",
          "start": 2042022,
          "end": 2043898,
          "strand": "+",
          "slug": "ovca2"
        },
        {
          "symbol": "HIC1",
          "ensemblId": "ENSG00000177374",
          "biotype": "protein_coding",
          "start": 2054154,
          "end": 2063241,
          "strand": "+",
          "slug": "hic1"
        },
        {
          "symbol": "SMG6",
          "ensemblId": "ENSG00000070366",
          "biotype": "protein_coding",
          "start": 2059839,
          "end": 2303934,
          "strand": "-",
          "slug": "smg6"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "inherited-fibrinolytic-disorders",
        "name": "Κληρονομικές διαταραχές της fibrinolysis",
        "diseases": [
          {
            "mondoId": "MONDO:0009883",
            "name": "Έλλειψη αναστολέα πλασμίνης-α2",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Προκαλείται από αλλαγές και στα δύο αντίγραφα του SERPINF2· οι θρόμβοι διαλύονται πολύ νωρίς, με αποτέλεσμα αιμορραγία που μπορεί να είναι σοβαρή, συμπεριλαμβανομένης αιμορραγίας στις αρθρώσεις.",
            "management": "Το τρανεξαμικό οξύ, φάρμακο που επιβραδύνει τη διάλυση των θρόμβων, είναι αποτελεσματικό στην πρόληψη και τη θεραπεία της αιμορραγίας.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant",
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/inherited-fibrinolytic-disorders"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-umbilical-stump-bleeding",
        "name": "Abnormal umbilical stump bleeding",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-umbilical-stump-bleeding"
      },
      {
        "slug": "gingival-bleeding",
        "name": "Bleeding gums",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gingival-bleeding"
      },
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      },
      {
        "slug": "joint-hemorrhage",
        "name": "Bleeding within a joint",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/joint-hemorrhage"
      },
      {
        "slug": "intracranial-hemorrhage",
        "name": "Bleeding within the skull",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intracranial-hemorrhage"
      },
      {
        "slug": "hematuria",
        "name": "Blood in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hematuria"
      },
      {
        "slug": "bone-pain",
        "name": "Bone pain",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bone-pain"
      },
      {
        "slug": "bruising-susceptibility",
        "name": "Bruising susceptibility",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bruising-susceptibility"
      },
      {
        "slug": "persistent-bleeding-after-trauma",
        "name": "Excessive bleeding after minor trauma",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/persistent-bleeding-after-trauma"
      },
      {
        "slug": "hemothorax",
        "name": "Hemothorax",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hemothorax"
      },
      {
        "slug": "intramuscular-hematoma",
        "name": "Intramuscular hematoma",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/intramuscular-hematoma"
      },
      {
        "slug": "reduced-euglobulin-clot-lysis-time",
        "name": "Reduced euglobulin clot lysis time",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/reduced-euglobulin-clot-lysis-time"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}