{
  "url": "https://dantelabs.com/el/genes/robo2",
  "gene": {
    "slug": "robo2",
    "symbol": "ROBO2",
    "name": "roundabout guidance receptor 2",
    "hgnc": "HGNC:10250",
    "summary": null,
    "location": "3p12.3",
    "locusType": "gene with protein product",
    "aliases": [
      "KIAA1568"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000185008",
    "entrezId": 6092,
    "omim": [
      "602431"
    ],
    "uniprot": [
      "Q9HCK4"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "3",
      "start": 77040099,
      "end": 77649964,
      "strand": "+",
      "ensemblTranscript": "ENST00000696593.1",
      "refseqTranscript": "NM_001395656.1",
      "ensemblProtein": "ENSP00000512738.1",
      "refseqProtein": "NP_001382585.1",
      "exons": [
        {
          "start": 77040099,
          "end": 77040846
        },
        {
          "start": 77098014,
          "end": 77098340
        },
        {
          "start": 77477414,
          "end": 77477571
        },
        {
          "start": 77481099,
          "end": 77481219
        },
        {
          "start": 77493244,
          "end": 77493382
        },
        {
          "start": 77522775,
          "end": 77522902
        },
        {
          "start": 77527403,
          "end": 77527414
        },
        {
          "start": 77546338,
          "end": 77546462
        },
        {
          "start": 77550818,
          "end": 77550989
        },
        {
          "start": 77557944,
          "end": 77558149
        },
        {
          "start": 77562651,
          "end": 77562732
        },
        {
          "start": 77563167,
          "end": 77563329
        },
        {
          "start": 77564954,
          "end": 77565120
        },
        {
          "start": 77568313,
          "end": 77568434
        },
        {
          "start": 77574499,
          "end": 77574730
        },
        {
          "start": 77577490,
          "end": 77577614
        },
        {
          "start": 77579947,
          "end": 77580118
        },
        {
          "start": 77588751,
          "end": 77588933
        },
        {
          "start": 77595142,
          "end": 77595184
        },
        {
          "start": 77596623,
          "end": 77596750
        },
        {
          "start": 77602210,
          "end": 77602491
        },
        {
          "start": 77607798,
          "end": 77607954
        },
        {
          "start": 77617513,
          "end": 77617773
        },
        {
          "start": 77622227,
          "end": 77622432
        },
        {
          "start": 77634870,
          "end": 77635043
        },
        {
          "start": 77642671,
          "end": 77642943
        },
        {
          "start": 77644704,
          "end": 77644904
        },
        {
          "start": 77646054,
          "end": 77649964
        }
      ],
      "cds": {
        "start": 77040786,
        "end": 77646055
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "3",
      "start": 75955846,
      "end": 77699115,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 76430233,
      "end": 78259830,
      "genes": [],
      "truncated": false
    },
    "reports": [
      {
        "slug": "congenital-anomalies-kidney-urinary-tract",
        "name": "Συγγενείς ανωμαλίες νεφρών και ουροφόρου συστήματος",
        "diseases": [
          {
            "mondoId": "MONDO:0006007",
            "name": "Κυστεουρητηρική παλινδρόμηση",
            "genes": 2,
            "inheritance": null,
            "description": "Αντίστροφη ροή ούρων από την ουροδόχο κύστη προς τους νεφρούς, η οποία μπορεί να εμφανίζεται σε οικογένειες και αυξάνει τον κίνδυνο νεφρικής λοίμωξης και ουλοποίησης.",
            "management": "Η γνώση μπορεί να οδηγήσει σε νωρίτερη αξιολόγηση των ουρολοιμώξεων σε εσάς και στα παιδιά σας.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/congenital-anomalies-kidney-urinary-tract"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "renal-hypoplasia",
        "name": "Small kidneys",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/renal-hypoplasia"
      },
      {
        "slug": "vesicoureteral-reflux",
        "name": "Vesicoureteral reflux",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/vesicoureteral-reflux"
      }
    ],
    "related": [
      {
        "slug": "sox17",
        "symbol": "SOX17",
        "name": "SRY-box transcription factor 17",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/sox17"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}