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          "ensemblId": "ENSG00000141582",
          "biotype": "protein_coding",
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        {
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          "biotype": "protein_coding",
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        {
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          "biotype": "protein_coding",
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        {
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          "biotype": "protein_coding",
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          "slug": "gaa"
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        {
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          "ensemblId": "ENSG00000141543",
          "biotype": "protein_coding",
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          "strand": "-",
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        {
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          "ensemblId": "ENSG00000141527",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "card14"
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        {
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          "ensemblId": "ENSG00000181523",
          "biotype": "protein_coding",
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        {
          "symbol": "SLC26A11",
          "ensemblId": "ENSG00000181045",
          "biotype": "protein_coding",
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        {
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          "ensemblId": "ENSG00000173818",
          "biotype": "protein_coding",
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        {
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          "biotype": "protein_coding",
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          "slug": "nptx1"
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        {
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          "biotype": "protein_coding",
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        {
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          "ensemblId": "ENSG00000289764",
          "biotype": "protein_coding",
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      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "moyamoya-disease",
        "name": "Νόσος Moyamoya",
        "diseases": [
          {
            "mondoId": "MONDO:0016820",
            "name": "Νόσος Moyamoya",
            "genes": 4,
            "inheritance": null,
            "description": "Προοδευτική στένωση των αρτηριών στη βάση του εγκεφάλου, που σχετίζεται με μεταβολές στο RNF213 (γονίδιο προδιάθεσης με μειωμένη διεισδυτικότητα, ιδιαίτερα συχνό σε πληθυσμούς της Ανατολικής Ασίας), στο ACTA2 ή στο GUCY1A1, οι οποίες μπορούν να προκαλέσουν εγκεφαλικά επεισόδια ή μικροεγκεφαλικά επεισόδια.",
            "management": "Η γνώση της πάθησης βοηθά στην έγκαιρη αξιολόγηση συμπτωμάτων, όπως η παροδική αδυναμία, και στην πρόσβαση σε εξειδικευμένη πρόληψη εγκεφαλικού επεισοδίου και χειρουργική θεραπεία.",
            "evidence": {
              "gencc": [
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant",
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/moyamoya-disease"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-cerebral-vascular-morphology",
        "name": "Abnormality of the cerebral blood vessels",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-cerebral-vascular-morphology"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "transient-ischemic-attack",
        "name": "Mini stroke",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/transient-ischemic-attack"
      },
      {
        "slug": "moyamoya-phenomenon",
        "name": "Moyamoya phenomenon",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/moyamoya-phenomenon"
      },
      {
        "slug": "telangiectasia",
        "name": "Spider veins",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/telangiectasia"
      },
      {
        "slug": "ventriculomegaly",
        "name": "Ventriculomegaly",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ventriculomegaly"
      }
    ],
    "related": [
      {
        "slug": "acta2",
        "symbol": "ACTA2",
        "name": "actin alpha 2, smooth muscle",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/acta2"
      },
      {
        "slug": "gucy1a1",
        "symbol": "GUCY1A1",
        "name": "guanylate cyclase 1 soluble subunit alpha 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/gucy1a1"
      },
      {
        "slug": "samhd1",
        "symbol": "SAMHD1",
        "name": "SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/samhd1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}