{
  "url": "https://dantelabs.com/el/genes/p2ry12",
  "gene": {
    "slug": "p2ry12",
    "symbol": "P2RY12",
    "name": "purinergic receptor P2Y12",
    "hgnc": "HGNC:18124",
    "summary": null,
    "location": "3q25.1",
    "locusType": "gene with protein product",
    "aliases": [
      "P2Y12",
      "SP1999",
      "HORK3"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000169313",
    "entrezId": 64805,
    "omim": [
      "600515"
    ],
    "uniprot": [
      "Q9H244"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "3",
      "start": 151336843,
      "end": 151384753,
      "strand": "-",
      "ensemblTranscript": "ENST00000302632.4",
      "refseqTranscript": "NM_022788.5",
      "ensemblProtein": "ENSP00000307259.4",
      "refseqProtein": "NP_073625.1",
      "exons": [
        {
          "start": 151336843,
          "end": 151338859
        },
        {
          "start": 151340596,
          "end": 151340760
        },
        {
          "start": 151384692,
          "end": 151384753
        }
      ],
      "cds": {
        "start": 151337817,
        "end": 151338845
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "3",
      "start": 151055168,
      "end": 151102600,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 150860798,
      "end": 151860797,
      "genes": [
        {
          "symbol": "MINDY4B",
          "ensemblId": "ENSG00000214237",
          "biotype": "protein_coding",
          "start": 150870376,
          "end": 150905439,
          "strand": "-",
          "slug": "mindy4b"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000260234",
          "biotype": "protein_coding",
          "start": 150882997,
          "end": 150941743,
          "strand": "-"
        },
        {
          "symbol": "CLRN1",
          "ensemblId": "ENSG00000163646",
          "biotype": "protein_coding",
          "start": 150926163,
          "end": 150972727,
          "strand": "-",
          "slug": "clrn1"
        },
        {
          "symbol": "MED12L",
          "ensemblId": "ENSG00000144893",
          "biotype": "protein_coding",
          "start": 151085286,
          "end": 151437072,
          "strand": "+",
          "slug": "med12l"
        },
        {
          "symbol": "GPR171",
          "ensemblId": "ENSG00000174946",
          "biotype": "protein_coding",
          "start": 151197832,
          "end": 151203216,
          "strand": "-",
          "slug": "gpr171"
        },
        {
          "symbol": "P2RY14",
          "ensemblId": "ENSG00000174944",
          "biotype": "protein_coding",
          "start": 151212115,
          "end": 151278811,
          "strand": "-",
          "slug": "p2ry14"
        },
        {
          "symbol": "GPR87",
          "ensemblId": "ENSG00000138271",
          "biotype": "protein_coding",
          "start": 151294086,
          "end": 151316820,
          "strand": "-",
          "slug": "gpr87"
        },
        {
          "symbol": "P2RY13",
          "ensemblId": "ENSG00000181631",
          "biotype": "protein_coding",
          "start": 151326312,
          "end": 151329555,
          "strand": "-",
          "slug": "p2ry13"
        },
        {
          "symbol": "IGSF10",
          "ensemblId": "ENSG00000152580",
          "biotype": "protein_coding",
          "start": 151425384,
          "end": 151461186,
          "strand": "-",
          "slug": "igsf10"
        },
        {
          "symbol": "AADACL2",
          "ensemblId": "ENSG00000197953",
          "biotype": "protein_coding",
          "start": 151733916,
          "end": 151761339,
          "strand": "+",
          "slug": "aadacl2"
        },
        {
          "symbol": "AADAC",
          "ensemblId": "ENSG00000114771",
          "biotype": "protein_coding",
          "start": 151813931,
          "end": 151853589,
          "strand": "+",
          "slug": "aadac"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "inherited-platelet-function-disorders",
        "name": "Κληρονομικές διαταραχές της λειτουργίας των αιμοπεταλίων",
        "diseases": [
          {
            "mondoId": "MONDO:0012354",
            "name": "Διαταραχή αιμοπεταλίων σχετιζόμενη με το P2RY12 (Διαταραχή αιμορραγίας τύπου αιμοπεταλίων 8)",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Υπολειπόμενη διαταραχή του υποδοχέα ADP των αιμοπεταλίων, που κωδικοποιείται από το P2RY12, με αποτέλεσμα ήπια έως μέτρια αιμορραγία.",
            "management": "Η γνώση της πάθησης βοηθά στον προγραμματισμό της πρόληψης αιμορραγίας σε χειρουργικές επεμβάσεις, οδοντιατρικές θεραπείες και τοκετό, και στην αποφυγή φαρμάκων που επηρεάζουν τη λειτουργία των αιμοπεταλίων.",
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant",
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/inherited-platelet-function-disorders"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      },
      {
        "slug": "epistaxis",
        "name": "Bloody nose",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/epistaxis"
      },
      {
        "slug": "bruising-susceptibility",
        "name": "Bruising susceptibility",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/bruising-susceptibility"
      },
      {
        "slug": "ecchymosis",
        "name": "Ecchymosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/ecchymosis"
      },
      {
        "slug": "persistent-bleeding-after-trauma",
        "name": "Excessive bleeding after minor trauma",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/persistent-bleeding-after-trauma"
      },
      {
        "slug": "impaired-adp-induced-platelet-aggregation",
        "name": "Impaired ADP-induced platelet aggregation",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/impaired-adp-induced-platelet-aggregation"
      },
      {
        "slug": "prolonged-bleeding-after-surgery",
        "name": "Prolonged bleeding after surgery",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/prolonged-bleeding-after-surgery"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}