{
  "url": "https://dantelabs.com/el/genes/nlgn3",
  "gene": {
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    "symbol": "NLGN3",
    "name": "neuroligin 3",
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    "locusType": "gene with protein product",
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    "entrezId": 54413,
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      "300336"
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    "uniprot": [
      "Q9NZ94"
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      "refseqTranscript": "NM_181303.2",
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      "refseqProtein": "NP_851820.1",
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      ],
      "cds": {
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    },
    "grch37": {
      "build": "GRCh37",
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      "strand": "+"
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    "neighbourhood": {
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          "symbol": "TEX11",
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        {
          "symbol": "SLC7A3",
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        {
          "symbol": "SNX12",
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        {
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        {
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        {
          "symbol": "",
          "ensemblId": "ENSG00000285171",
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          "end": 71111575,
          "strand": "-"
        },
        {
          "symbol": "IL2RG",
          "ensemblId": "ENSG00000147168",
          "biotype": "protein_coding",
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          "strand": "-",
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        {
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        {
          "symbol": "GJB1",
          "ensemblId": "ENSG00000169562",
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        {
          "symbol": "ZMYM3",
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        {
          "symbol": "NONO",
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          "biotype": "protein_coding",
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        },
        {
          "symbol": "ITGB1BP2",
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          "biotype": "protein_coding",
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          "end": 71305371,
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        },
        {
          "symbol": "TAF1",
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          "biotype": "protein_coding",
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        {
          "symbol": "OGT",
          "ensemblId": "ENSG00000147162",
          "biotype": "protein_coding",
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          "slug": "ogt"
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        {
          "symbol": "GCNA",
          "ensemblId": "ENSG00000147174",
          "biotype": "protein_coding",
          "start": 71578436,
          "end": 71613590,
          "strand": "+",
          "slug": "gcna"
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        {
          "symbol": "CXCR3",
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          "biotype": "protein_coding",
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          "slug": "cxcr3"
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      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "autism-spectrum-disorder",
        "name": "Διαταραχή του φάσματος του αυτισμού",
        "diseases": [
          {
            "mondoId": "MONDO:0020836",
            "name": "Αυτισμός, προδιάθεση για (μονογονιδιακές μορφές)",
            "genes": 6,
            "inheritance": null,
            "description": "Μονογονιδιακές συνεισφορές στον αυτισμό, συμπεριλαμβανομένων παραλλαγών στα NLGN3, NLGN4X, PTCHD1, SHANK2, TBR1 και CHD8.",
            "management": null,
            "evidence": {
              "gencc": [
                "G2P"
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              "acmgSf": false,
              "inheritance": []
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/autism-spectrum-disorder"
      },
      {
        "slug": "epilepsy-report",
        "name": "Επιληψία (Πλήρες Πάνελ)",
        "diseases": [
          {
            "mondoId": "MONDO:0100148",
            "name": "Σύνθετη Νευροαναπτυξιακή Διαταραχή Συνδεδεμένη με το Χρωμόσωμα X",
            "genes": 25,
            "inheritance": null,
            "description": "Σύνθετη νευροαναπτυξιακή διαταραχή που μεταβιβάζεται με κληρονομικότητα συνδεδεμένη με το χρωμόσωμα X και χαρακτηρίζεται από διανοητική αναπηρία, αυτισμό και επιληψία.",
            "management": null,
            "evidence": {
              "gencc": [
                "PanelApp Australia"
              ],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": []
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/epilepsy-report"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "autism",
        "name": "Autism",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/autism"
      },
      {
        "slug": "delayed-speech-and-language-development",
        "name": "Delayed speech and language development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-speech-and-language-development"
      },
      {
        "slug": "eeg-abnormality",
        "name": "EEG abnormality",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/eeg-abnormality"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "abnormal-nonverbal-communicative-behavior",
        "name": "Impaired use of nonverbal behaviors",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/abnormal-nonverbal-communicative-behavior"
      },
      {
        "slug": "increased-serum-serotonin",
        "name": "Increased serum serotonin",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-serum-serotonin"
      },
      {
        "slug": "inflexible-adherence-to-routines",
        "name": "Inflexible adherence to routines",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/inflexible-adherence-to-routines"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "lack-of-peer-relationships",
        "name": "Lack of peer relationships",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/lack-of-peer-relationships"
      },
      {
        "slug": "lack-of-spontaneous-play",
        "name": "Lack of spontaneous play",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/lack-of-spontaneous-play"
      },
      {
        "slug": "reduced-ability-to-form-peer-relationships",
        "name": "Reduced ability to form peer relationships",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/reduced-ability-to-form-peer-relationships"
      },
      {
        "slug": "motor-stereotypy",
        "name": "Repetitive movements",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/motor-stereotypy"
      },
      {
        "slug": "restrictive-behavior",
        "name": "Restrictive behavior",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/restrictive-behavior"
      }
    ],
    "related": [
      {
        "slug": "nlgn4x",
        "symbol": "NLGN4X",
        "name": "neuroligin 4 X-linked",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/nlgn4x"
      },
      {
        "slug": "ptchd1",
        "symbol": "PTCHD1",
        "name": "patched domain containing 1",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/ptchd1"
      },
      {
        "slug": "arhgef9",
        "symbol": "ARHGEF9",
        "name": "Cdc42 guanine nucleotide exchange factor 9",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/arhgef9"
      },
      {
        "slug": "arx",
        "symbol": "ARX",
        "name": "aristaless related homeobox",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/arx"
      },
      {
        "slug": "chd8",
        "symbol": "CHD8",
        "name": "chromodomain helicase DNA binding protein 8",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/chd8"
      },
      {
        "slug": "clcn4",
        "symbol": "CLCN4",
        "name": "Cl-/H+ antiporter 4",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/clcn4"
      },
      {
        "slug": "cnksr2",
        "symbol": "CNKSR2",
        "name": "connector enhancer of kinase suppressor of Ras 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/cnksr2"
      },
      {
        "slug": "frmpd4",
        "symbol": "FRMPD4",
        "name": "FERM and PDZ domain containing 4",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/frmpd4"
      },
      {
        "slug": "ftsj1",
        "symbol": "FTSJ1",
        "name": "FtsJ RNA 2'-O-methyltransferase 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/ftsj1"
      },
      {
        "slug": "gria3",
        "symbol": "GRIA3",
        "name": "glutamate ionotropic receptor AMPA type subunit 3",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/gria3"
      },
      {
        "slug": "hnrnph2",
        "symbol": "HNRNPH2",
        "name": "heterogeneous nuclear ribonucleoprotein H2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/hnrnph2"
      },
      {
        "slug": "il1rapl1",
        "symbol": "IL1RAPL1",
        "name": "interleukin 1 receptor accessory protein like 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/il1rapl1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}