{
  "url": "https://dantelabs.com/el/genes/myl4",
  "gene": {
    "slug": "myl4",
    "symbol": "MYL4",
    "name": "myosin light chain 4",
    "hgnc": "HGNC:7585",
    "summary": null,
    "location": "17q21.32",
    "locusType": "gene with protein product",
    "aliases": [
      "ALC1",
      "AMLC",
      "GT1",
      "PRO1957"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000198336",
    "entrezId": 4635,
    "omim": [
      "160770"
    ],
    "uniprot": [
      "P12829"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "17",
      "start": 47209348,
      "end": 47223679,
      "strand": "+",
      "ensemblTranscript": "ENST00000393450.5",
      "refseqTranscript": "NM_002476.2",
      "ensemblProtein": "ENSP00000377096.1",
      "refseqProtein": "NP_002467.1",
      "exons": [
        {
          "start": 47209348,
          "end": 47209557
        },
        {
          "start": 47213799,
          "end": 47213826
        },
        {
          "start": 47219904,
          "end": 47220053
        },
        {
          "start": 47221682,
          "end": 47221855
        },
        {
          "start": 47222380,
          "end": 47222457
        },
        {
          "start": 47223014,
          "end": 47223057
        },
        {
          "start": 47223509,
          "end": 47223679
        }
      ],
      "cds": {
        "start": 47209423,
        "end": 47223042
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "17",
      "start": 45277812,
      "end": 45301045,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 46716514,
      "end": 47716513,
      "genes": [
        {
          "symbol": "NSF",
          "ensemblId": "ENSG00000073969",
          "biotype": "protein_coding",
          "start": 46590661,
          "end": 46757679,
          "strand": "+",
          "slug": "nsf"
        },
        {
          "symbol": "WNT3",
          "ensemblId": "ENSG00000108379",
          "biotype": "protein_coding",
          "start": 46762493,
          "end": 46833154,
          "strand": "-",
          "slug": "wnt3"
        },
        {
          "symbol": "WNT9B",
          "ensemblId": "ENSG00000158955",
          "biotype": "protein_coding",
          "start": 46833201,
          "end": 46886730,
          "strand": "+",
          "slug": "wnt9b"
        },
        {
          "symbol": "GOSR2",
          "ensemblId": "ENSG00000108433",
          "biotype": "protein_coding",
          "start": 46923075,
          "end": 46975524,
          "strand": "+",
          "slug": "gosr2"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000262633",
          "biotype": "protein_coding",
          "start": 46923133,
          "end": 47049932,
          "strand": "+"
        },
        {
          "symbol": "RPRML",
          "ensemblId": "ENSG00000179673",
          "biotype": "protein_coding",
          "start": 46978156,
          "end": 46979253,
          "strand": "-",
          "slug": "rprml"
        },
        {
          "symbol": "CDC27",
          "ensemblId": "ENSG00000004897",
          "biotype": "protein_coding",
          "start": 47117703,
          "end": 47189422,
          "strand": "-",
          "slug": "cdc27"
        },
        {
          "symbol": "ITGB3",
          "ensemblId": "ENSG00000259207",
          "biotype": "protein_coding",
          "start": 47253649,
          "end": 47323218,
          "strand": "+",
          "slug": "itgb3"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000259753",
          "biotype": "protein_coding",
          "start": 47253897,
          "end": 47344292,
          "strand": "+"
        },
        {
          "symbol": "EFCAB13",
          "ensemblId": "ENSG00000178852",
          "biotype": "protein_coding",
          "start": 47323290,
          "end": 47441312,
          "strand": "+",
          "slug": "efcab13"
        },
        {
          "symbol": "NPEPPS",
          "ensemblId": "ENSG00000141279",
          "biotype": "protein_coding",
          "start": 47522942,
          "end": 47624707,
          "strand": "+",
          "slug": "npepps"
        },
        {
          "symbol": "KPNB1",
          "ensemblId": "ENSG00000108424",
          "biotype": "protein_coding",
          "start": 47649476,
          "end": 47685505,
          "strand": "+",
          "slug": "kpnb1"
        },
        {
          "symbol": "TBKBP1",
          "ensemblId": "ENSG00000198933",
          "biotype": "protein_coding",
          "start": 47694030,
          "end": 47712063,
          "strand": "+",
          "slug": "tbkbp1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "familial-atrial-fibrillation",
        "name": "Οικογενής κολπική μαρμαρυγή",
        "diseases": [
          {
            "mondoId": "MONDO:0018054",
            "name": "Οικογενής κολπική μαρμαρυγή",
            "genes": 4,
            "inheritance": "autosomal-dominant",
            "description": "Κολπική μαρμαρυγή που εμφανίζεται στην οικογένεια και συνδέεται με μεταβολές σε γονίδια όπως τα KCNQ1, KCNJ2, GJA5, MYL4, NPPA και SCN5A.",
            "management": "Η γνώση αυτού του ιστορικού στηρίζει τον πρώιμο έλεγχο ΗΚΓ για τους συγγενείς σας και την έγκαιρη συζήτηση για την πρόληψη του εγκεφαλικού επεισοδίου.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/familial-atrial-fibrillation"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "dyspnea",
        "name": "Breathing difficulty",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dyspnea"
      },
      {
        "slug": "chest-pain",
        "name": "Chest pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chest-pain"
      },
      {
        "slug": "third-degree-atrioventricular-block",
        "name": "Complete heart block",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/third-degree-atrioventricular-block"
      },
      {
        "slug": "exercise-intolerance",
        "name": "Decreased ability to exercise",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/exercise-intolerance"
      },
      {
        "slug": "vertigo",
        "name": "Dizziness",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/vertigo"
      },
      {
        "slug": "syncope",
        "name": "Fainting spell",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/syncope"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "first-degree-atrioventricular-block",
        "name": "First degree atrioventricular block",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/first-degree-atrioventricular-block"
      },
      {
        "slug": "myocardial-infarction",
        "name": "Heart attack",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myocardial-infarction"
      },
      {
        "slug": "palpitations",
        "name": "Palpitations",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/palpitations"
      },
      {
        "slug": "paroxysmal-atrial-fibrillation",
        "name": "Paroxysmal atrial fibrillation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/paroxysmal-atrial-fibrillation"
      },
      {
        "slug": "permanent-atrial-fibrillation",
        "name": "Permanent atrial fibrillation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/permanent-atrial-fibrillation"
      },
      {
        "slug": "atrial-fibrillation",
        "name": "Quivering upper heart chambers resulting in irregular heartbeat",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/atrial-fibrillation"
      },
      {
        "slug": "bradycardia",
        "name": "Slow heartbeats",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bradycardia"
      },
      {
        "slug": "thromboembolic-stroke",
        "name": "Thromboembolic stroke",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thromboembolic-stroke"
      },
      {
        "slug": "thromboembolism",
        "name": "Thromboembolism",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thromboembolism"
      }
    ],
    "related": [
      {
        "slug": "gja5",
        "symbol": "GJA5",
        "name": "gap junction protein alpha 5",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/gja5"
      },
      {
        "slug": "kcnj2",
        "symbol": "KCNJ2",
        "name": "potassium inwardly rectifying channel subfamily J member 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/kcnj2"
      },
      {
        "slug": "kcnq1",
        "symbol": "KCNQ1",
        "name": "potassium voltage-gated channel subfamily Q member 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/kcnq1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.19-9814e911",
      "panel": "2026-10-19",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}