{
  "url": "https://dantelabs.com/el/genes/mdfic",
  "gene": {
    "slug": "mdfic",
    "symbol": "MDFIC",
    "name": "MyoD family inhibitor domain containing",
    "hgnc": "HGNC:28870",
    "summary": null,
    "location": "7q31.1-q31.2",
    "locusType": "gene with protein product",
    "aliases": [
      "HIC",
      "MDFIC1"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000135272",
    "entrezId": 29969,
    "omim": [
      "614511"
    ],
    "uniprot": [
      "Q9P1T7"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "7",
      "start": 114922094,
      "end": 115019917,
      "strand": "+",
      "ensemblTranscript": "ENST00000393486.6",
      "refseqTranscript": "NM_001166345.3",
      "ensemblProtein": "ENSP00000377126.1",
      "refseqProtein": "NP_001159817.1",
      "exons": [
        {
          "start": 114922094,
          "end": 114922636
        },
        {
          "start": 114922927,
          "end": 114923127
        },
        {
          "start": 114942275,
          "end": 114942397
        },
        {
          "start": 114979506,
          "end": 114979781
        },
        {
          "start": 115015688,
          "end": 115019917
        }
      ],
      "cds": {
        "start": 114923034,
        "end": 115015935
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "7",
      "start": 114562209,
      "end": 114659256,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 114471006,
      "end": 115471005,
      "genes": [
        {
          "symbol": "FOXP2",
          "ensemblId": "ENSG00000128573",
          "biotype": "protein_coding",
          "start": 114086186,
          "end": 114693772,
          "strand": "+",
          "slug": "foxp2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "primary-lymphoedema-lymphatic-malformations",
        "name": "Primär Λεμφοίδημα & Λεμφικές Delaying",
        "diseases": [
          {
            "mondoId": "MONDO:0031043",
            "name": "Λεμφικό κακοήθη σχηματισμός 12",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Σπάνια κληρονομική λεμφική διαταραχή που επηρεάζει τα κεντρικά λεμφικά αγγεία.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/primary-lymphoedema-lymphatic-malformations"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "fetal-ascites",
        "name": "Fetal ascites",
        "systems": [
          "abnormality-of-prenatal-development-or-birth",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/fetal-ascites"
      },
      {
        "slug": "fetal-chylothorax",
        "name": "Fetal chylothorax",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/fetal-chylothorax"
      },
      {
        "slug": "fetal-pericardial-effusion",
        "name": "Fetal pericardial effusion",
        "systems": [
          "abnormality-of-prenatal-development-or-birth",
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fetal-pericardial-effusion"
      },
      {
        "slug": "fetal-pleural-effusion",
        "name": "Fetal pleural effusion",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/fetal-pleural-effusion"
      },
      {
        "slug": "polyhydramnios",
        "name": "High levels of amniotic fluid",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/polyhydramnios"
      },
      {
        "slug": "hydrocele-testis",
        "name": "Hydrocele testis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hydrocele-testis"
      },
      {
        "slug": "hyperkeratosis",
        "name": "Hyperkeratosis",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hyperkeratosis"
      },
      {
        "slug": "inguinal-hernia",
        "name": "Inguinal hernia",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/inguinal-hernia"
      },
      {
        "slug": "neonatal-respiratory-distress",
        "name": "Neonatal respiratory distress",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/neonatal-respiratory-distress"
      },
      {
        "slug": "nonimmune-hydrops-fetalis",
        "name": "Nonimmune hydrops fetalis",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/nonimmune-hydrops-fetalis"
      },
      {
        "slug": "pleural-thickening",
        "name": "Pleural thickening",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pleural-thickening"
      },
      {
        "slug": "recurrent-upper-and-lower-respiratory-tract-infections",
        "name": "Recurrent upper and lower respiratory tract infections",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-upper-and-lower-respiratory-tract-infections"
      },
      {
        "slug": "lymphedema",
        "name": "Swelling caused by excess lymph fluid under skin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/lymphedema"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}