{
  "url": "https://dantelabs.com/el/genes/krt12",
  "gene": {
    "slug": "krt12",
    "symbol": "KRT12",
    "name": "keratin 12",
    "hgnc": "HGNC:6414",
    "summary": null,
    "location": "17q21.2",
    "locusType": "gene with protein product",
    "aliases": [
      "K12"
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    "previousSymbols": [],
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    "entrezId": 3859,
    "omim": [
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    "uniprot": [
      "Q99456"
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      "release": "v1.5",
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    },
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    },
    "neighbourhood": {
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        {
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        {
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        {
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        {
          "symbol": "CCR7",
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          "strand": "-",
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        {
          "symbol": "SMARCE1",
          "ensemblId": "ENSG00000073584",
          "biotype": "protein_coding",
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        {
          "symbol": "",
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        {
          "symbol": "KRT222",
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        {
          "symbol": "KRT24",
          "ensemblId": "ENSG00000167916",
          "biotype": "protein_coding",
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        {
          "symbol": "KRT25",
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          "biotype": "protein_coding",
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        {
          "symbol": "KRT26",
          "ensemblId": "ENSG00000186393",
          "biotype": "protein_coding",
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          "slug": "krt26"
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        {
          "symbol": "KRT27",
          "ensemblId": "ENSG00000171446",
          "biotype": "protein_coding",
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          "strand": "-",
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        {
          "symbol": "KRT28",
          "ensemblId": "ENSG00000173908",
          "biotype": "protein_coding",
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          "slug": "krt28"
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        {
          "symbol": "KRT10",
          "ensemblId": "ENSG00000186395",
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        {
          "symbol": "KRT20",
          "ensemblId": "ENSG00000171431",
          "biotype": "protein_coding",
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        {
          "symbol": "KRT23",
          "ensemblId": "ENSG00000108244",
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        {
          "symbol": "KRT39",
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        {
          "symbol": "KRT40",
          "ensemblId": "ENSG00000204889",
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        {
          "symbol": "KRTAP3-3",
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          "biotype": "protein_coding",
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        {
          "symbol": "KRTAP3-2",
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          "biotype": "protein_coding",
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        {
          "symbol": "KRTAP3-1",
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        {
          "symbol": "KRTAP1-5",
          "ensemblId": "ENSG00000221852",
          "biotype": "protein_coding",
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        {
          "symbol": "KRTAP1-4",
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        {
          "symbol": "KRTAP1-3",
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          "biotype": "protein_coding",
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        {
          "symbol": "KRTAP1-1",
          "ensemblId": "ENSG00000188581",
          "biotype": "protein_coding",
          "start": 41040541,
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          "slug": "krtap1-1"
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        {
          "symbol": "KRTAP2-1",
          "ensemblId": "ENSG00000212725",
          "biotype": "protein_coding",
          "start": 41046541,
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          "slug": "krtap2-1"
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        {
          "symbol": "KRTAP2-2",
          "ensemblId": "ENSG00000214518",
          "biotype": "protein_coding",
          "start": 41054498,
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          "strand": "-",
          "slug": "krtap2-2"
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        {
          "symbol": "KRTAP2-3",
          "ensemblId": "ENSG00000212724",
          "biotype": "protein_coding",
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        {
          "symbol": "KRTAP2-4",
          "ensemblId": "ENSG00000213417",
          "biotype": "protein_coding",
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          "slug": "krtap2-4"
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        {
          "symbol": "KRTAP4-7",
          "ensemblId": "ENSG00000240871",
          "biotype": "protein_coding",
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          "slug": "krtap4-7"
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        {
          "symbol": "KRTAP4-8",
          "ensemblId": "ENSG00000204880",
          "biotype": "protein_coding",
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          "slug": "krtap4-8"
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        {
          "symbol": "KRTAP4-16",
          "ensemblId": "ENSG00000241241",
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        {
          "symbol": "KRTAP4-9",
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          "slug": "krtap4-9"
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        {
          "symbol": "KRTAP4-11",
          "ensemblId": "ENSG00000212721",
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        {
          "symbol": "KRTAP4-12",
          "ensemblId": "ENSG00000213416",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "krtap4-12"
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        {
          "symbol": "KRTAP4-6",
          "ensemblId": "ENSG00000198090",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "krtap4-6"
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        {
          "symbol": "KRTAP4-5",
          "ensemblId": "ENSG00000198271",
          "biotype": "protein_coding",
          "start": 41148924,
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          "strand": "-",
          "slug": "krtap4-5"
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        {
          "symbol": "KRTAP4-4",
          "ensemblId": "ENSG00000171396",
          "biotype": "protein_coding",
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          "slug": "krtap4-4"
        },
        {
          "symbol": "KRTAP4-3",
          "ensemblId": "ENSG00000196156",
          "biotype": "protein_coding",
          "start": 41167231,
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          "strand": "-",
          "slug": "krtap4-3"
        },
        {
          "symbol": "KRTAP4-2",
          "ensemblId": "ENSG00000244537",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "krtap4-2"
        },
        {
          "symbol": "KRTAP4-1",
          "ensemblId": "ENSG00000198443",
          "biotype": "protein_coding",
          "start": 41184100,
          "end": 41184911,
          "strand": "-",
          "slug": "krtap4-1"
        },
        {
          "symbol": "KRTAP9-1",
          "ensemblId": "ENSG00000240542",
          "biotype": "protein_coding",
          "start": 41189887,
          "end": 41190639,
          "strand": "+",
          "slug": "krtap9-1"
        },
        {
          "symbol": "KRTAP9-2",
          "ensemblId": "ENSG00000239886",
          "biotype": "protein_coding",
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          "end": 41227652,
          "strand": "+",
          "slug": "krtap9-2"
        },
        {
          "symbol": "KRTAP9-3",
          "ensemblId": "ENSG00000204873",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "krtap9-3"
        },
        {
          "symbol": "KRTAP9-8",
          "ensemblId": "ENSG00000187272",
          "biotype": "protein_coding",
          "start": 41237999,
          "end": 41239004,
          "strand": "+",
          "slug": "krtap9-8"
        },
        {
          "symbol": "KRTAP9-4",
          "ensemblId": "ENSG00000241595",
          "biotype": "protein_coding",
          "start": 41249687,
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          "strand": "+",
          "slug": "krtap9-4"
        },
        {
          "symbol": "KRTAP9-9",
          "ensemblId": "ENSG00000198083",
          "biotype": "protein_coding",
          "start": 41255384,
          "end": 41256364,
          "strand": "+",
          "slug": "krtap9-9"
        },
        {
          "symbol": "KRTAP9-6",
          "ensemblId": "ENSG00000212659",
          "biotype": "protein_coding",
          "start": 41265378,
          "end": 41265860,
          "strand": "+",
          "slug": "krtap9-6"
        },
        {
          "symbol": "KRTAP9-7",
          "ensemblId": "ENSG00000180386",
          "biotype": "protein_coding",
          "start": 41275698,
          "end": 41276207,
          "strand": "+",
          "slug": "krtap9-7"
        },
        {
          "symbol": "KRTAP29-1",
          "ensemblId": "ENSG00000212658",
          "biotype": "protein_coding",
          "start": 41301826,
          "end": 41302851,
          "strand": "-",
          "slug": "krtap29-1"
        },
        {
          "symbol": "KRTAP16-1",
          "ensemblId": "ENSG00000212657",
          "biotype": "protein_coding",
          "start": 41307700,
          "end": 41309309,
          "strand": "-",
          "slug": "krtap16-1"
        },
        {
          "symbol": "KRTAP17-1",
          "ensemblId": "ENSG00000186860",
          "biotype": "protein_coding",
          "start": 41314912,
          "end": 41315710,
          "strand": "-",
          "slug": "krtap17-1"
        },
        {
          "symbol": "KRT33A",
          "ensemblId": "ENSG00000006059",
          "biotype": "protein_coding",
          "start": 41345665,
          "end": 41350828,
          "strand": "-",
          "slug": "krt33a"
        },
        {
          "symbol": "KRT33B",
          "ensemblId": "ENSG00000131738",
          "biotype": "protein_coding",
          "start": 41363498,
          "end": 41369813,
          "strand": "-",
          "slug": "krt33b"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-corneal-dystrophies",
        "name": "Κληρονομικές δυστροφίες κερατοειδούς",
        "diseases": [
          {
            "mondoId": "MONDO:0018102",
            "name": "Δυστροφία κερατοειδούς",
            "genes": 19,
            "inheritance": null,
            "description": "Ομάδα κληρονομικών παθήσεων που επηρεάζουν ένα ή περισσότερα στρώματα του κερατοειδούς, όπως η δυστροφία ενδοθηλίου Fuchs (συχνά συνδεδεμένη με επέκταση επαναλήψεων στο TCF4), οι κοκκώδεις και πλεγματικές δυστροφίες που σχετίζονται με το TGFBI, και σπανιότερα είδη που προκαλούνται από γονίδια όπως τα SLC4A11, COL8A2, ZEB1 και CHST6.",
            "management": "Στους φορείς παραλλαγών του TGFBI συνήθως συνιστάται να αποφεύγουν τη διαθλαστική χειρουργική με laser (LASIK ή PRK), καθώς αυτή μπορεί να επιδεινώσει τα εναποθέματα. Η μεταμόσχευση κερατοειδούς μπορεί να αποκαταστήσει την όραση σε προχωρημένη νόσο.",
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/hereditary-corneal-dystrophies"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "corneal-dystrophy",
        "name": "Corneal dystrophy",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/corneal-dystrophy"
      },
      {
        "slug": "reduced-visual-acuity",
        "name": "Decreased clarity of vision",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/reduced-visual-acuity"
      },
      {
        "slug": "photophobia",
        "name": "Extreme sensitivity of the eyes to light",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/photophobia"
      },
      {
        "slug": "epiphora",
        "name": "Increased tears",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/epiphora"
      },
      {
        "slug": "punctate-opacification-of-the-cornea",
        "name": "Punctate opacification of the cornea",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/punctate-opacification-of-the-cornea"
      }
    ],
    "related": [
      {
        "slug": "chst6",
        "symbol": "CHST6",
        "name": "carbohydrate sulfotransferase 6",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/chst6"
      },
      {
        "slug": "col17a1",
        "symbol": "COL17A1",
        "name": "collagen type XVII alpha 1 chain",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/col17a1"
      },
      {
        "slug": "col8a2",
        "symbol": "COL8A2",
        "name": "collagen type VIII alpha 2 chain",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/col8a2"
      },
      {
        "slug": "dcn",
        "symbol": "DCN",
        "name": "decorin",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/dcn"
      },
      {
        "slug": "grhl2",
        "symbol": "GRHL2",
        "name": "grainyhead like transcription factor 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/grhl2"
      },
      {
        "slug": "gsn",
        "symbol": "GSN",
        "name": "gelsolin",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/gsn"
      },
      {
        "slug": "krt3",
        "symbol": "KRT3",
        "name": "keratin 3",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/krt3"
      },
      {
        "slug": "mcoln1",
        "symbol": "MCOLN1",
        "name": "mucolipin TRP cation channel 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/mcoln1"
      },
      {
        "slug": "nlrp1",
        "symbol": "NLRP1",
        "name": "NLR family pyrin domain containing 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/nlrp1"
      },
      {
        "slug": "ovol2",
        "symbol": "OVOL2",
        "name": "ovo like zinc finger 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/ovol2"
      },
      {
        "slug": "pikfyve",
        "symbol": "PIKFYVE",
        "name": "phosphoinositide kinase, FYVE-type zinc finger containing",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/pikfyve"
      },
      {
        "slug": "prdx3",
        "symbol": "PRDX3",
        "name": "peroxiredoxin 3",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/prdx3"
      }
    ],
    "sources": {
      "bundleId": "2026.10.18-8b139e39",
      "panel": "2026-10-18",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}