{
  "url": "https://dantelabs.com/el/genes/kcne3",
  "gene": {
    "slug": "kcne3",
    "symbol": "KCNE3",
    "name": "potassium voltage-gated channel subfamily E regulatory subunit 3",
    "hgnc": "HGNC:6243",
    "summary": null,
    "location": "11q13.4",
    "locusType": "gene with protein product",
    "aliases": [
      "MiRP2",
      "HOKPP"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000175538",
    "entrezId": 10008,
    "omim": [
      "604433"
    ],
    "uniprot": [
      "Q9Y6H6"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "11",
      "start": 74454841,
      "end": 74467549,
      "strand": "-",
      "ensemblTranscript": "ENST00000310128.9",
      "refseqTranscript": "NM_005472.5",
      "ensemblProtein": "ENSP00000310557.4",
      "refseqProtein": "NP_005463.1",
      "exons": [
        {
          "start": 74454841,
          "end": 74457603
        },
        {
          "start": 74461955,
          "end": 74462103
        },
        {
          "start": 74467398,
          "end": 74467549
        }
      ],
      "cds": {
        "start": 74457252,
        "end": 74457563
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "11",
      "start": 74165886,
      "end": 74178774,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 73961195,
      "end": 74961194,
      "genes": [
        {
          "symbol": "DNAJB13",
          "ensemblId": "ENSG00000187726",
          "biotype": "protein_coding",
          "start": 73951014,
          "end": 73970366,
          "strand": "+",
          "slug": "dnajb13"
        },
        {
          "symbol": "UCP2",
          "ensemblId": "ENSG00000175567",
          "biotype": "protein_coding",
          "start": 73973431,
          "end": 73983542,
          "strand": "-",
          "slug": "ucp2"
        },
        {
          "symbol": "UCP3",
          "ensemblId": "ENSG00000175564",
          "biotype": "protein_coding",
          "start": 74000277,
          "end": 74009241,
          "strand": "-",
          "slug": "ucp3"
        },
        {
          "symbol": "C2CD3",
          "ensemblId": "ENSG00000168014",
          "biotype": "protein_coding",
          "start": 74012718,
          "end": 74171210,
          "strand": "-",
          "slug": "c2cd3"
        },
        {
          "symbol": "PPME1",
          "ensemblId": "ENSG00000214517",
          "biotype": "protein_coding",
          "start": 74171083,
          "end": 74254714,
          "strand": "+",
          "slug": "ppme1"
        },
        {
          "symbol": "P4HA3",
          "ensemblId": "ENSG00000149380",
          "biotype": "protein_coding",
          "start": 74235801,
          "end": 74311685,
          "strand": "-",
          "slug": "p4ha3"
        },
        {
          "symbol": "PGM2L1",
          "ensemblId": "ENSG00000165434",
          "biotype": "protein_coding",
          "start": 74330315,
          "end": 74398473,
          "strand": "-",
          "slug": "pgm2l1"
        },
        {
          "symbol": "LIPT2",
          "ensemblId": "ENSG00000175536",
          "biotype": "protein_coding",
          "start": 74490503,
          "end": 74493730,
          "strand": "-",
          "slug": "lipt2"
        },
        {
          "symbol": "POLD3",
          "ensemblId": "ENSG00000077514",
          "biotype": "protein_coding",
          "start": 74493851,
          "end": 74669117,
          "strand": "+",
          "slug": "pold3"
        },
        {
          "symbol": "CHRDL2",
          "ensemblId": "ENSG00000054938",
          "biotype": "protein_coding",
          "start": 74696429,
          "end": 74731625,
          "strand": "-",
          "slug": "chrdl2"
        },
        {
          "symbol": "RNF169",
          "ensemblId": "ENSG00000166439",
          "biotype": "protein_coding",
          "start": 74748832,
          "end": 74842413,
          "strand": "+",
          "slug": "rnf169"
        },
        {
          "symbol": "XRRA1",
          "ensemblId": "ENSG00000166435",
          "biotype": "protein_coding",
          "start": 74807739,
          "end": 74949200,
          "strand": "-",
          "slug": "xrra1"
        },
        {
          "symbol": "SPCS2",
          "ensemblId": "ENSG00000118363",
          "biotype": "protein_coding",
          "start": 74949259,
          "end": 74981633,
          "strand": "+",
          "slug": "spcs2"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "arrhythmia",
        "name": "Abnormal heart rate",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arrhythmia"
      },
      {
        "slug": "abnormal-muscle-fiber-morphology",
        "name": "Abnormal muscle fiber morphology",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-muscle-fiber-morphology"
      },
      {
        "slug": "adrenocortical-adenoma",
        "name": "Adrenocortical adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/adrenocortical-adenoma"
      },
      {
        "slug": "complete-right-bundle-branch-block",
        "name": "Complete right bundle branch block",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/complete-right-bundle-branch-block"
      },
      {
        "slug": "respiratory-insufficiency-due-to-muscle-weakness",
        "name": "Decreased lung function due to weak breathing muscles",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/respiratory-insufficiency-due-to-muscle-weakness"
      },
      {
        "slug": "diminished-deep-tendon-reflex",
        "name": "Diminished deep tendon reflex",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/diminished-deep-tendon-reflex"
      },
      {
        "slug": "tachycardia",
        "name": "Elevated heart rate",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tachycardia"
      },
      {
        "slug": "emg-abnormality",
        "name": "EMG abnormality",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/emg-abnormality"
      },
      {
        "slug": "episodic-flaccid-weakness",
        "name": "Episodic flaccid weakness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/episodic-flaccid-weakness"
      },
      {
        "slug": "exercise-induced-muscle-fatigue",
        "name": "Exercise-induced muscle fatigue",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/exercise-induced-muscle-fatigue"
      },
      {
        "slug": "syncope",
        "name": "Fainting spell",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/syncope"
      },
      {
        "slug": "fatigable-weakness-of-respiratory-muscles",
        "name": "Fatigable weakness of respiratory muscles",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/fatigable-weakness-of-respiratory-muscles"
      },
      {
        "slug": "fatty-replacement-of-skeletal-muscle",
        "name": "Fatty replacement of skeletal muscle",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/fatty-replacement-of-skeletal-muscle"
      },
      {
        "slug": "first-degree-atrioventricular-block",
        "name": "First degree atrioventricular block",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/first-degree-atrioventricular-block"
      },
      {
        "slug": "cardiac-arrest",
        "name": "Heart stops beating",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cardiac-arrest"
      },
      {
        "slug": "impaired-myocardial-contractility",
        "name": "Impaired myocardial contractility",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/impaired-myocardial-contractility"
      },
      {
        "slug": "increased-intramyocellular-lipid-droplets",
        "name": "Increased intramyocellular lipid droplets",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-intramyocellular-lipid-droplets"
      },
      {
        "slug": "late-onset-proximal-muscle-weakness",
        "name": "Late-onset proximal muscle weakness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/late-onset-proximal-muscle-weakness"
      },
      {
        "slug": "mildly-elevated-creatine-kinase",
        "name": "Mildly elevated creatine kinase",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/mildly-elevated-creatine-kinase"
      },
      {
        "slug": "muscle-spasm",
        "name": "Muscle spasm",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/muscle-spasm"
      },
      {
        "slug": "myotonia",
        "name": "Myotonia",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/myotonia"
      },
      {
        "slug": "pain",
        "name": "Pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pain"
      },
      {
        "slug": "paralysis",
        "name": "Paralysis",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/paralysis"
      },
      {
        "slug": "paroxysmal-ventricular-tachycardia",
        "name": "Paroxysmal ventricular tachycardia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/paroxysmal-ventricular-tachycardia"
      },
      {
        "slug": "periodic-hypokalemic-paresis",
        "name": "Periodic hypokalemic paresis",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/periodic-hypokalemic-paresis"
      },
      {
        "slug": "postprandial-hyperglycemia",
        "name": "Postprandial hyperglycemia",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/postprandial-hyperglycemia"
      },
      {
        "slug": "episodic-hypokalemia",
        "name": "Recurrent low potassium",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/episodic-hypokalemia"
      },
      {
        "slug": "respiratory-paralysis",
        "name": "Respiratory paralysis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/respiratory-paralysis"
      },
      {
        "slug": "sick-sinus-syndrome",
        "name": "Sick sinus syndrome",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sick-sinus-syndrome"
      },
      {
        "slug": "st-segment-elevation",
        "name": "ST segment elevation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/st-segment-elevation"
      },
      {
        "slug": "supraventricular-tachycardia",
        "name": "Supraventricular tachycardia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/supraventricular-tachycardia"
      },
      {
        "slug": "trifascicular-block",
        "name": "Trifascicular block",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/trifascicular-block"
      },
      {
        "slug": "ventricular-arrhythmia",
        "name": "Ventricular arrhythmia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/ventricular-arrhythmia"
      },
      {
        "slug": "ventricular-fibrillation",
        "name": "Ventricular fibrillation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ventricular-fibrillation"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}