{
  "url": "https://dantelabs.com/el/genes/il10rb",
  "gene": {
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    "symbol": "IL10RB",
    "name": "interleukin 10 receptor subunit beta",
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    "locusType": "gene with protein product",
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      "IL-10R2"
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      "D21S58",
      "D21S66"
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    "ensemblId": "ENSG00000243646",
    "entrezId": 3588,
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    "uniprot": [
      "Q08334"
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    },
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    "neighbourhood": {
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        {
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        {
          "symbol": "OLIG1",
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        {
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        {
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        {
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        {
          "symbol": "IFNGR2",
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        {
          "symbol": "TMEM50B",
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        {
          "symbol": "DNAJC28",
          "ensemblId": "ENSG00000177692",
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        {
          "symbol": "GART",
          "ensemblId": "ENSG00000159131",
          "biotype": "protein_coding",
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          "slug": "gart"
        },
        {
          "symbol": "SON",
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        },
        {
          "symbol": "DONSON",
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          "biotype": "protein_coding",
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        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000249209",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "CRYZL1",
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          "slug": "cryzl1"
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        {
          "symbol": "ITSN1",
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          "biotype": "protein_coding",
          "start": 33642400,
          "end": 33899861,
          "strand": "+",
          "slug": "itsn1"
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      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "inflammatory-bowel-diseases-ibd-74",
        "name": "Φλεγμονώδεις νόσοι του εντέρου (IBD)",
        "diseases": [
          {
            "mondoId": "MONDO:0005265",
            "name": "Φλεγμονώδης νόσος του εντέρου",
            "genes": 5,
            "inheritance": null,
            "description": "Ένα φάσμα φλεγμονωδών νοσημάτων του λεπτού και του παχέος εντέρου αγνώστου αιτιολογίας. Περιλαμβάνει τη νόσο του Crohn, την ελκώδη κολίτιδα και την κολίτιδα απροσδιόριστου τύπου.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/inflammatory-bowel-diseases-ibd-74"
      },
      {
        "slug": "immunodeficiency-disease",
        "name": "Άλλα έμφυτα σφάλματα της ανοσίας",
        "diseases": [
          {
            "mondoId": "MONDO:0003778",
            "name": "Ανοσολογική ανεπάρκεια με γενετική βάση",
            "genes": 114,
            "inheritance": null,
            "description": "Κληρονομικές διαταραχές του ανοσοποιητικού συστήματος που οφείλονται σε μεταβολές σε μεμονωμένα γονίδια και επηρεάζουν τον τρόπο με τον οποίο ο οργανισμός καταπολεμά τις λοιμώξεις ή ρυθμίζει τη φλεγμονή.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/el/conditions/immunodeficiency-disease"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "rectovaginal-fistula",
        "name": "Abnormal connection between rectum and vagina",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/rectovaginal-fistula"
      },
      {
        "slug": "enterocolitis",
        "name": "Enterocolitis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/enterocolitis"
      },
      {
        "slug": "enterocutaneous-fistula",
        "name": "Enterocutaneous fistula",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/enterocutaneous-fistula"
      },
      {
        "slug": "folliculitis",
        "name": "Folliculitis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/folliculitis"
      },
      {
        "slug": "pancolitis",
        "name": "Pancolitis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pancolitis"
      },
      {
        "slug": "perianal-abscess",
        "name": "Perianal abscess",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/perianal-abscess"
      },
      {
        "slug": "recurrent-bronchitis",
        "name": "Recurrent bronchitis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-bronchitis"
      }
    ],
    "related": [
      {
        "slug": "il10",
        "symbol": "IL10",
        "name": "interleukin 10",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/il10"
      },
      {
        "slug": "il10ra",
        "symbol": "IL10RA",
        "name": "interleukin 10 receptor subunit alpha",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/il10ra"
      },
      {
        "slug": "adam17",
        "symbol": "ADAM17",
        "name": "ADAM metallopeptidase domain 17",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/adam17"
      },
      {
        "slug": "adar",
        "symbol": "ADAR",
        "name": "adenosine deaminase RNA specific",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/adar"
      },
      {
        "slug": "aicda",
        "symbol": "AICDA",
        "name": "activation induced cytidine deaminase",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/aicda"
      },
      {
        "slug": "ap3b1",
        "symbol": "AP3B1",
        "name": "adaptor related protein complex 3 subunit beta 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/ap3b1"
      },
      {
        "slug": "atp6ap1",
        "symbol": "ATP6AP1",
        "name": "ATPase H+ transporting accessory protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/atp6ap1"
      },
      {
        "slug": "bcl10",
        "symbol": "BCL10",
        "name": "BCL10 immune signaling adaptor",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/bcl10"
      },
      {
        "slug": "bcl11b",
        "symbol": "BCL11B",
        "name": "BCL11 transcription factor B",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/bcl11b"
      },
      {
        "slug": "blnk",
        "symbol": "BLNK",
        "name": "B cell linker",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/blnk"
      },
      {
        "slug": "bloc1s6",
        "symbol": "BLOC1S6",
        "name": "biogenesis of lysosomal organelles complex 1 subunit 6",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/bloc1s6"
      },
      {
        "slug": "btk",
        "symbol": "BTK",
        "name": "Bruton tyrosine kinase",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/btk"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}