{
  "url": "https://dantelabs.com/el/genes/il10ra",
  "gene": {
    "slug": "il10ra",
    "symbol": "IL10RA",
    "name": "interleukin 10 receptor subunit alpha",
    "hgnc": "HGNC:5964",
    "summary": null,
    "location": "11q23.3",
    "locusType": "gene with protein product",
    "aliases": [
      "HIL-10R",
      "CDW210A",
      "CD210a",
      "CD210"
    ],
    "previousSymbols": [
      "IL10R"
    ],
    "ensemblId": "ENSG00000110324",
    "entrezId": 3587,
    "omim": [
      "146933"
    ],
    "uniprot": [
      "Q13651"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "11",
      "start": 117986394,
      "end": 118001483,
      "strand": "+",
      "ensemblTranscript": "ENST00000227752.8",
      "refseqTranscript": "NM_001558.4",
      "ensemblProtein": "ENSP00000227752.4",
      "refseqProtein": "NP_001549.2",
      "exons": [
        {
          "start": 117986394,
          "end": 117986534
        },
        {
          "start": 117988382,
          "end": 117988502
        },
        {
          "start": 117989442,
          "end": 117989620
        },
        {
          "start": 117993241,
          "end": 117993410
        },
        {
          "start": 117993999,
          "end": 117994149
        },
        {
          "start": 117995589,
          "end": 117995710
        },
        {
          "start": 117998715,
          "end": 118001483
        }
      ],
      "cds": {
        "start": 117986468,
        "end": 117999641
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "11",
      "start": 117857063,
      "end": 117872196,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 117493939,
      "end": 118493938,
      "genes": [
        {
          "symbol": "DSCAML1",
          "ensemblId": "ENSG00000177103",
          "biotype": "protein_coding",
          "start": 117427772,
          "end": 117817525,
          "strand": "-",
          "slug": "dscaml1"
        },
        {
          "symbol": "FXYD2",
          "ensemblId": "ENSG00000137731",
          "biotype": "protein_coding",
          "start": 117800839,
          "end": 117828734,
          "strand": "-",
          "slug": "fxyd2"
        },
        {
          "symbol": "FXYD6-FXYD2",
          "ensemblId": "ENSG00000255245",
          "biotype": "protein_coding",
          "start": 117820163,
          "end": 117876667,
          "strand": "-",
          "slug": "fxyd6-fxyd2"
        },
        {
          "symbol": "FXYD6",
          "ensemblId": "ENSG00000137726",
          "biotype": "protein_coding",
          "start": 117833023,
          "end": 117877675,
          "strand": "-",
          "slug": "fxyd6"
        },
        {
          "symbol": "TMPRSS13",
          "ensemblId": "ENSG00000137747",
          "biotype": "protein_coding",
          "start": 117900641,
          "end": 117929459,
          "strand": "-",
          "slug": "tmprss13"
        },
        {
          "symbol": "SMIM35",
          "ensemblId": "ENSG00000255274",
          "biotype": "protein_coding",
          "start": 118003634,
          "end": 118088299,
          "strand": "-",
          "slug": "smim35"
        },
        {
          "symbol": "TMPRSS4",
          "ensemblId": "ENSG00000137648",
          "biotype": "protein_coding",
          "start": 118076986,
          "end": 118125510,
          "strand": "+",
          "slug": "tmprss4"
        },
        {
          "symbol": "SCN4B",
          "ensemblId": "ENSG00000177098",
          "biotype": "protein_coding",
          "start": 118133377,
          "end": 118152906,
          "strand": "-",
          "slug": "scn4b"
        },
        {
          "symbol": "SCN2B",
          "ensemblId": "ENSG00000149575",
          "biotype": "protein_coding",
          "start": 118162806,
          "end": 118176653,
          "strand": "-",
          "slug": "scn2b"
        },
        {
          "symbol": "JAML",
          "ensemblId": "ENSG00000160593",
          "biotype": "protein_coding",
          "start": 118193725,
          "end": 118226323,
          "strand": "-",
          "slug": "jaml"
        },
        {
          "symbol": "MPZL3",
          "ensemblId": "ENSG00000160588",
          "biotype": "protein_coding",
          "start": 118226690,
          "end": 118252375,
          "strand": "-",
          "slug": "mpzl3"
        },
        {
          "symbol": "MPZL2",
          "ensemblId": "ENSG00000149573",
          "biotype": "protein_coding",
          "start": 118253416,
          "end": 118264536,
          "strand": "-",
          "slug": "mpzl2"
        },
        {
          "symbol": "CD3E",
          "ensemblId": "ENSG00000198851",
          "biotype": "protein_coding",
          "start": 118304701,
          "end": 118316175,
          "strand": "+",
          "slug": "cd3e"
        },
        {
          "symbol": "CD3D",
          "ensemblId": "ENSG00000167286",
          "biotype": "protein_coding",
          "start": 118334537,
          "end": 118342713,
          "strand": "-",
          "slug": "cd3d"
        },
        {
          "symbol": "CD3G",
          "ensemblId": "ENSG00000160654",
          "biotype": "protein_coding",
          "start": 118344338,
          "end": 118355161,
          "strand": "+",
          "slug": "cd3g"
        },
        {
          "symbol": "UBE4A",
          "ensemblId": "ENSG00000110344",
          "biotype": "protein_coding",
          "start": 118359578,
          "end": 118399211,
          "strand": "+",
          "slug": "ube4a"
        },
        {
          "symbol": "ATP5MG",
          "ensemblId": "ENSG00000167283",
          "biotype": "protein_coding",
          "start": 118401345,
          "end": 118433278,
          "strand": "+",
          "slug": "atp5mg"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000285827",
          "biotype": "protein_coding",
          "start": 118401602,
          "end": 118482737,
          "strand": "+"
        },
        {
          "symbol": "KMT2A",
          "ensemblId": "ENSG00000118058",
          "biotype": "protein_coding",
          "start": 118436456,
          "end": 118526832,
          "strand": "+",
          "slug": "kmt2a"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "inflammatory-bowel-diseases-ibd-74",
        "name": "Φλεγμονώδεις νόσοι του εντέρου (IBD)",
        "diseases": [
          {
            "mondoId": "MONDO:0005265",
            "name": "Φλεγμονώδης νόσος του εντέρου",
            "genes": 5,
            "inheritance": null,
            "description": "Ένα φάσμα φλεγμονωδών νοσημάτων του λεπτού και του παχέος εντέρου αγνώστου αιτιολογίας. Περιλαμβάνει τη νόσο του Crohn, την ελκώδη κολίτιδα και την κολίτιδα απροσδιόριστου τύπου.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/inflammatory-bowel-diseases-ibd-74"
      },
      {
        "slug": "immunodeficiency-disease",
        "name": "Άλλα έμφυτα σφάλματα της ανοσίας",
        "diseases": [
          {
            "mondoId": "MONDO:0003778",
            "name": "Ανοσολογική ανεπάρκεια με γενετική βάση",
            "genes": 114,
            "inheritance": null,
            "description": "Κληρονομικές διαταραχές του ανοσοποιητικού συστήματος που οφείλονται σε μεταβολές σε μεμονωμένα γονίδια και επηρεάζουν τον τρόπο με τον οποίο ο οργανισμός καταπολεμά τις λοιμώξεις ή ρυθμίζει τη φλεγμονή.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/el/conditions/immunodeficiency-disease"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "colitis",
        "name": "Colitis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/colitis"
      },
      {
        "slug": "crohn-s-disease",
        "name": "Crohn's disease",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/crohn-s-disease"
      },
      {
        "slug": "enterocolitis",
        "name": "Enterocolitis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/enterocolitis"
      },
      {
        "slug": "folliculitis",
        "name": "Folliculitis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/folliculitis"
      },
      {
        "slug": "growth-delay",
        "name": "Growth delay",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/growth-delay"
      },
      {
        "slug": "oral-ulcer",
        "name": "Mouth sore",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/oral-ulcer"
      },
      {
        "slug": "perianal-abscess",
        "name": "Perianal abscess",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/perianal-abscess"
      },
      {
        "slug": "pyoderma",
        "name": "Pus-filled lesion",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pyoderma"
      },
      {
        "slug": "hematochezia",
        "name": "Rectal bleeding",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hematochezia"
      }
    ],
    "related": [
      {
        "slug": "il10",
        "symbol": "IL10",
        "name": "interleukin 10",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/il10"
      },
      {
        "slug": "il10rb",
        "symbol": "IL10RB",
        "name": "interleukin 10 receptor subunit beta",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/il10rb"
      },
      {
        "slug": "adam17",
        "symbol": "ADAM17",
        "name": "ADAM metallopeptidase domain 17",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/adam17"
      },
      {
        "slug": "adar",
        "symbol": "ADAR",
        "name": "adenosine deaminase RNA specific",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/adar"
      },
      {
        "slug": "aicda",
        "symbol": "AICDA",
        "name": "activation induced cytidine deaminase",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/aicda"
      },
      {
        "slug": "ap3b1",
        "symbol": "AP3B1",
        "name": "adaptor related protein complex 3 subunit beta 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/ap3b1"
      },
      {
        "slug": "atp6ap1",
        "symbol": "ATP6AP1",
        "name": "ATPase H+ transporting accessory protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/atp6ap1"
      },
      {
        "slug": "bcl10",
        "symbol": "BCL10",
        "name": "BCL10 immune signaling adaptor",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/bcl10"
      },
      {
        "slug": "bcl11b",
        "symbol": "BCL11B",
        "name": "BCL11 transcription factor B",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/bcl11b"
      },
      {
        "slug": "blnk",
        "symbol": "BLNK",
        "name": "B cell linker",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/blnk"
      },
      {
        "slug": "bloc1s6",
        "symbol": "BLOC1S6",
        "name": "biogenesis of lysosomal organelles complex 1 subunit 6",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/bloc1s6"
      },
      {
        "slug": "btk",
        "symbol": "BTK",
        "name": "Bruton tyrosine kinase",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/btk"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}