{
  "url": "https://dantelabs.com/el/genes/homer2",
  "gene": {
    "slug": "homer2",
    "symbol": "HOMER2",
    "name": "homer scaffold protein 2",
    "hgnc": "HGNC:17513",
    "summary": null,
    "location": "15q25.2",
    "locusType": "gene with protein product",
    "aliases": [
      "CPD",
      "Cupidin",
      "Vesl-2",
      "HOMER-2B",
      "HOMER-2",
      "HOMER-2A",
      "DFNA68"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000103942",
    "entrezId": 9455,
    "omim": [
      "604799"
    ],
    "uniprot": [
      "Q9NSB8"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "15",
      "start": 82848983,
      "end": 82952720,
      "strand": "-",
      "ensemblTranscript": "ENST00000450735.7",
      "refseqTranscript": "NM_004839.4",
      "ensemblProtein": "ENSP00000407634.2",
      "refseqProtein": "NP_004830.2",
      "exons": [
        {
          "start": 82848983,
          "end": 82849903
        },
        {
          "start": 82851151,
          "end": 82851231
        },
        {
          "start": 82852142,
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        },
        {
          "start": 82854644,
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        },
        {
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        },
        {
          "start": 82864167,
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        },
        {
          "start": 82875273,
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        },
        {
          "start": 82892685,
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        },
        {
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        }
      ],
      "cds": {
        "start": 82849715,
        "end": 82952535
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "15",
      "start": 83509838,
      "end": 83654661,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 82400852,
      "end": 83400851,
      "genes": [
        {
          "symbol": "GOLGA6L9",
          "ensemblId": "ENSG00000197978",
          "biotype": "protein_coding",
          "start": 82429816,
          "end": 82439153,
          "strand": "+",
          "slug": "golga6l9"
        },
        {
          "symbol": "RPS17",
          "ensemblId": "ENSG00000182774",
          "biotype": "protein_coding",
          "start": 82536592,
          "end": 82540622,
          "strand": "-",
          "slug": "rps17"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000260836",
          "biotype": "protein_coding",
          "start": 82536788,
          "end": 82573194,
          "strand": "-"
        },
        {
          "symbol": "CPEB1",
          "ensemblId": "ENSG00000214575",
          "biotype": "protein_coding",
          "start": 82543201,
          "end": 82648861,
          "strand": "-",
          "slug": "cpeb1"
        },
        {
          "symbol": "AP3B2",
          "ensemblId": "ENSG00000103723",
          "biotype": "protein_coding",
          "start": 82659281,
          "end": 82710112,
          "strand": "-",
          "slug": "ap3b2"
        },
        {
          "symbol": "FSD2",
          "ensemblId": "ENSG00000186628",
          "biotype": "protein_coding",
          "start": 82755362,
          "end": 82806148,
          "strand": "-",
          "slug": "fsd2"
        },
        {
          "symbol": "WHAMM",
          "ensemblId": "ENSG00000156232",
          "biotype": "protein_coding",
          "start": 82809581,
          "end": 82836108,
          "strand": "+",
          "slug": "whamm"
        },
        {
          "symbol": "RAMAC",
          "ensemblId": "ENSG00000169612",
          "biotype": "protein_coding",
          "start": 82986199,
          "end": 82991057,
          "strand": "+",
          "slug": "ramac"
        },
        {
          "symbol": "C15orf40",
          "ensemblId": "ENSG00000169609",
          "biotype": "protein_coding",
          "start": 82988364,
          "end": 83011647,
          "strand": "-",
          "slug": "c15orf40"
        },
        {
          "symbol": "BTBD1",
          "ensemblId": "ENSG00000064726",
          "biotype": "protein_coding",
          "start": 83016423,
          "end": 83067412,
          "strand": "-",
          "slug": "btbd1"
        },
        {
          "symbol": "TM6SF1",
          "ensemblId": "ENSG00000136404",
          "biotype": "protein_coding",
          "start": 83107369,
          "end": 83161068,
          "strand": "+",
          "slug": "tm6sf1"
        },
        {
          "symbol": "HDGFL3",
          "ensemblId": "ENSG00000166503",
          "biotype": "protein_coding",
          "start": 83112738,
          "end": 83208424,
          "strand": "-",
          "slug": "hdgfl3"
        },
        {
          "symbol": "BNC1",
          "ensemblId": "ENSG00000169594",
          "biotype": "protein_coding",
          "start": 83255884,
          "end": 83284664,
          "strand": "-",
          "slug": "bnc1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hearing-loss-and-deafness",
        "name": "Απώλεια ακοής και κώφωση",
        "diseases": [
          {
            "mondoId": "MONDO:0019587",
            "name": "Αυτοσωμικά επικρατής μη συνδρομική απώλεια ακοής",
            "genes": 39,
            "inheritance": "autosomal-dominant",
            "description": "Αυτοσωμικά επικρατής μορφή μη συνδρομικής κώφωσης.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0019497",
            "name": "Μη συνδρομική γενετική απώλεια ακοής",
            "genes": 97,
            "inheritance": null,
            "description": "Κληρονομική απώλεια ακοής χωρίς άλλα ιατρικά συμπτώματα, συμπεριλαμβανομένων των συχνών υπολειπόμενων μορφών που προκαλούνται από τα GJB2, OTOF, SLC26A4, STRC και πολλά άλλα γονίδια, καθώς και των επικρατουσών, των φυλοσύνδετων και των μιτοχονδριακών μορφών.",
            "management": "Η γνώση της γενετικής αιτίας μπορεί να καθοδηγήσει την υποστήριξη ακοής και τις αποφάσεις για εμφύτευμα κοχλία, την επιλεξιμότητα για κλινικές δοκιμές γονιδιακής θεραπείας (για παράδειγμα για το OTOF) και τη γενετική συμβουλευτική της οικογένειας.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/el/conditions/hearing-loss-and-deafness"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      }
    ],
    "related": [
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "name": "actin gamma 1",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/actg1"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "name": "ATPase phospholipid transporting 11A",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/atp11a"
      },
      {
        "slug": "atp2b2",
        "symbol": "ATP2B2",
        "name": "ATPase plasma membrane Ca2+ transporting 2",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/atp2b2"
      },
      {
        "slug": "cd164",
        "symbol": "CD164",
        "name": "CD164 molecule",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/cd164"
      },
      {
        "slug": "ceacam16",
        "symbol": "CEACAM16",
        "name": "CEA cell adhesion molecule 16, tectorial membrane component",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/ceacam16"
      },
      {
        "slug": "coch",
        "symbol": "COCH",
        "name": "cochlin",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/coch"
      },
      {
        "slug": "col11a1",
        "symbol": "COL11A1",
        "name": "collagen type XI alpha 1 chain",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/col11a1"
      },
      {
        "slug": "col11a2",
        "symbol": "COL11A2",
        "name": "collagen type XI alpha 2 chain",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/col11a2"
      },
      {
        "slug": "diaph1",
        "symbol": "DIAPH1",
        "name": "diaphanous related formin 1",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/diaph1"
      },
      {
        "slug": "eya4",
        "symbol": "EYA4",
        "name": "EYA transcriptional coactivator and phosphatase 4",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/eya4"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "name": "gap junction protein beta 2",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/gjb2"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "name": "gap junction protein beta 6",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/gjb6"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}