{
  "url": "https://dantelabs.com/el/genes/hnrnph2",
  "gene": {
    "slug": "hnrnph2",
    "symbol": "HNRNPH2",
    "name": "heterogeneous nuclear ribonucleoprotein H2",
    "hgnc": "HGNC:5042",
    "summary": null,
    "location": "Xq22.1",
    "locusType": "gene with protein product",
    "aliases": [
      "hnRNPH'",
      "FTP3",
      "HNRPH'"
    ],
    "previousSymbols": [
      "HNRPH2"
    ],
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    "omim": [
      "300610"
    ],
    "uniprot": [
      "P55795"
    ],
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      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "X",
      "start": 101408222,
      "end": 101414133,
      "strand": "+",
      "ensemblTranscript": "ENST00000316594.6",
      "refseqTranscript": "NM_019597.5",
      "ensemblProtein": "ENSP00000361927.2",
      "refseqProtein": "NP_062543.1",
      "exons": [
        {
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          "end": 101408319
        },
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          "end": 101414133
        }
      ],
      "cds": {
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        "end": 101413338
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "X",
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      "end": 100669121,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
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      "end": 101911177,
      "genes": [
        {
          "symbol": "XKRX",
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          "biotype": "protein_coding",
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          "end": 100929433,
          "strand": "-",
          "slug": "xkrx"
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        {
          "symbol": "ARL13A",
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          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "arl13a"
        },
        {
          "symbol": "TRMT2B",
          "ensemblId": "ENSG00000188917",
          "biotype": "protein_coding",
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          "end": 101052135,
          "strand": "-",
          "slug": "trmt2b"
        },
        {
          "symbol": "TMEM35A",
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          "biotype": "protein_coding",
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          "end": 101096367,
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          "slug": "tmem35a"
        },
        {
          "symbol": "CENPI",
          "ensemblId": "ENSG00000102384",
          "biotype": "protein_coding",
          "start": 101098150,
          "end": 101166126,
          "strand": "+",
          "slug": "cenpi"
        },
        {
          "symbol": "DRP2",
          "ensemblId": "ENSG00000102385",
          "biotype": "protein_coding",
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          "end": 101264502,
          "strand": "+",
          "slug": "drp2"
        },
        {
          "symbol": "TAF7L",
          "ensemblId": "ENSG00000102387",
          "biotype": "protein_coding",
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          "end": 101293057,
          "strand": "-",
          "slug": "taf7l"
        },
        {
          "symbol": "TIMM8A",
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          "biotype": "protein_coding",
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          "end": 101349001,
          "strand": "-",
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        },
        {
          "symbol": "BTK",
          "ensemblId": "ENSG00000010671",
          "biotype": "protein_coding",
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          "end": 101390796,
          "strand": "-",
          "slug": "btk"
        },
        {
          "symbol": "RPL36A",
          "ensemblId": "ENSG00000241343",
          "biotype": "protein_coding",
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          "end": 101396155,
          "strand": "+",
          "slug": "rpl36a"
        },
        {
          "symbol": "RPL36A-HNRNPH2",
          "ensemblId": "ENSG00000257529",
          "biotype": "protein_coding",
          "start": 101391011,
          "end": 101412297,
          "strand": "+",
          "slug": "rpl36a-hnrnph2"
        },
        {
          "symbol": "GLA",
          "ensemblId": "ENSG00000102393",
          "biotype": "protein_coding",
          "start": 101393273,
          "end": 101408012,
          "strand": "-",
          "slug": "gla"
        },
        {
          "symbol": "ARMCX4",
          "ensemblId": "ENSG00000196440",
          "biotype": "protein_coding",
          "start": 101418269,
          "end": 101535551,
          "strand": "+",
          "slug": "armcx4"
        },
        {
          "symbol": "ARMCX1",
          "ensemblId": "ENSG00000126947",
          "biotype": "protein_coding",
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          "end": 101554704,
          "strand": "+",
          "slug": "armcx1"
        },
        {
          "symbol": "ARMCX6",
          "ensemblId": "ENSG00000198960",
          "biotype": "protein_coding",
          "start": 101615118,
          "end": 101618011,
          "strand": "-",
          "slug": "armcx6"
        },
        {
          "symbol": "ARMCX3",
          "ensemblId": "ENSG00000102401",
          "biotype": "protein_coding",
          "start": 101622797,
          "end": 101627843,
          "strand": "+",
          "slug": "armcx3"
        },
        {
          "symbol": "ARMCX2",
          "ensemblId": "ENSG00000184867",
          "biotype": "protein_coding",
          "start": 101654024,
          "end": 101659924,
          "strand": "-",
          "slug": "armcx2"
        },
        {
          "symbol": "ZMAT1",
          "ensemblId": "ENSG00000166432",
          "biotype": "protein_coding",
          "start": 101882288,
          "end": 101932090,
          "strand": "-",
          "slug": "zmat1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "epilepsy-report",
        "name": "Επιληψία (Πλήρες Πάνελ)",
        "diseases": [
          {
            "mondoId": "MONDO:0100148",
            "name": "Σύνθετη Νευροαναπτυξιακή Διαταραχή Συνδεδεμένη με το Χρωμόσωμα X",
            "genes": 25,
            "inheritance": null,
            "description": "Σύνθετη νευροαναπτυξιακή διαταραχή που μεταβιβάζεται με κληρονομικότητα συνδεδεμένη με το χρωμόσωμα X και χαρακτηρίζεται από διανοητική αναπηρία, αυτισμό και επιληψία.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": []
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/epilepsy-report"
      },
      {
        "slug": "intellectual-disability",
        "name": "Νοητική αναπηρία",
        "diseases": [
          {
            "mondoId": "MONDO:0001071",
            "name": "νοητική αναπηρία",
            "genes": 233,
            "inheritance": null,
            "description": null,
            "management": null,
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": []
            },
            "sameAsReport": true,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/el/conditions/intellectual-disability"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "gait-disturbance",
        "name": "Abnormal gait",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gait-disturbance"
      },
      {
        "slug": "hypotelorism",
        "name": "Abnormally close eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypotelorism"
      },
      {
        "slug": "absent-speech",
        "name": "Absent speech development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/absent-speech"
      },
      {
        "slug": "gastroesophageal-reflux",
        "name": "Acid reflux",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/gastroesophageal-reflux"
      },
      {
        "slug": "aggressive-behavior",
        "name": "Aggressive behavior",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/aggressive-behavior"
      },
      {
        "slug": "almond-shaped-palpebral-fissure",
        "name": "Almond shaped eyes",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/almond-shaped-palpebral-fissure"
      },
      {
        "slug": "atrial-septal-defect",
        "name": "An opening in the wall separating the top two chambers of the heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/atrial-septal-defect"
      },
      {
        "slug": "anxiety",
        "name": "Anxiety",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/anxiety"
      },
      {
        "slug": "ataxia",
        "name": "Ataxia",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ataxia"
      },
      {
        "slug": "attention-deficit-hyperactivity-disorder",
        "name": "Attention deficit",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/attention-deficit-hyperactivity-disorder"
      },
      {
        "slug": "autistic-behavior",
        "name": "Autism spectrum disorder",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/autistic-behavior"
      },
      {
        "slug": "chronic-constipation",
        "name": "Chronic constipation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/chronic-constipation"
      },
      {
        "slug": "conspicuously-happy-disposition",
        "name": "Conspicuously happy disposition",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/conspicuously-happy-disposition"
      },
      {
        "slug": "curly-hair",
        "name": "Curly hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/curly-hair"
      },
      {
        "slug": "secondary-microcephaly",
        "name": "Development of small head that was not present at birth",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/secondary-microcephaly"
      },
      {
        "slug": "joint-hypermobility",
        "name": "Double-Jointed",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/joint-hypermobility"
      },
      {
        "slug": "drooling",
        "name": "Drooling",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/drooling"
      },
      {
        "slug": "pes-planus",
        "name": "Dropped arches",
        "systems": [
          "abnormality-of-limbs"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pes-planus"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "epicanthus",
        "name": "Eye folds",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/epicanthus"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "feeding-difficulties",
        "name": "Feeding difficulties",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/feeding-difficulties"
      },
      {
        "slug": "thick-vermilion-border",
        "name": "Full lips",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thick-vermilion-border"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "high-palate",
        "name": "High palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/high-palate"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "micrognathia",
        "name": "Little lower jaw",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/micrognathia"
      },
      {
        "slug": "arachnodactyly",
        "name": "Long slender fingers",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arachnodactyly"
      },
      {
        "slug": "developmental-regression",
        "name": "Loss of developmental milestones",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/developmental-regression"
      },
      {
        "slug": "low-hanging-columella",
        "name": "Low hanging columella",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/low-hanging-columella"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "midface-retrusion",
        "name": "Midface retrusion",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/midface-retrusion"
      },
      {
        "slug": "mitral-valve-prolapse",
        "name": "Mitral valve prolapse",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/mitral-valve-prolapse"
      },
      {
        "slug": "compulsive-behaviors",
        "name": "Obsessive compulsive behavior",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/compulsive-behaviors"
      },
      {
        "slug": "exotropia",
        "name": "Outward facing eye ball",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/exotropia"
      },
      {
        "slug": "pectus-carinatum",
        "name": "Pigeon chest",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pectus-carinatum"
      },
      {
        "slug": "prominent-fingertip-pads",
        "name": "Prominent fingertip pads",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-integument",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prominent-fingertip-pads"
      },
      {
        "slug": "hyperlordosis",
        "name": "Prominent swayback",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hyperlordosis"
      },
      {
        "slug": "recurrent-hand-flapping",
        "name": "Recurrent hand flapping",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-hand-flapping"
      },
      {
        "slug": "motor-stereotypy",
        "name": "Repetitive movements",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/motor-stereotypy"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "self-injurious-behavior",
        "name": "Self-injurious behavior",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/self-injurious-behavior"
      },
      {
        "slug": "short-palpebral-fissure",
        "name": "Short opening between the eyelids",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/short-palpebral-fissure"
      },
      {
        "slug": "short-philtrum",
        "name": "Short philtrum",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-philtrum"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "cerebellar-hypoplasia",
        "name": "Small cerebellum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cerebellar-hypoplasia"
      },
      {
        "slug": "hypertonia",
        "name": "Spasticity and rigidity of muscles",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertonia"
      },
      {
        "slug": "underdeveloped-nasal-alae",
        "name": "Underdeveloped tissue around nostril",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/underdeveloped-nasal-alae"
      },
      {
        "slug": "wide-mouth",
        "name": "Wide mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/wide-mouth"
      },
      {
        "slug": "hypertelorism",
        "name": "Wide-set eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertelorism"
      }
    ],
    "related": [
      {
        "slug": "arhgef9",
        "symbol": "ARHGEF9",
        "name": "Cdc42 guanine nucleotide exchange factor 9",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/arhgef9"
      },
      {
        "slug": "clcn4",
        "symbol": "CLCN4",
        "name": "Cl-/H+ antiporter 4",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/clcn4"
      },
      {
        "slug": "cnksr2",
        "symbol": "CNKSR2",
        "name": "connector enhancer of kinase suppressor of Ras 2",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/cnksr2"
      },
      {
        "slug": "frmpd4",
        "symbol": "FRMPD4",
        "name": "FERM and PDZ domain containing 4",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/frmpd4"
      },
      {
        "slug": "ftsj1",
        "symbol": "FTSJ1",
        "name": "FtsJ RNA 2'-O-methyltransferase 1",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/ftsj1"
      },
      {
        "slug": "gria3",
        "symbol": "GRIA3",
        "name": "glutamate ionotropic receptor AMPA type subunit 3",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/gria3"
      },
      {
        "slug": "il1rapl1",
        "symbol": "IL1RAPL1",
        "name": "interleukin 1 receptor accessory protein like 1",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/il1rapl1"
      },
      {
        "slug": "iqsec2",
        "symbol": "IQSEC2",
        "name": "IQ motif and Sec7 domain ArfGEF 2",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/iqsec2"
      },
      {
        "slug": "kdm5c",
        "symbol": "KDM5C",
        "name": "lysine demethylase 5C",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/kdm5c"
      },
      {
        "slug": "nexmif",
        "symbol": "NEXMIF",
        "name": "neurite extension and migration factor",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/nexmif"
      },
      {
        "slug": "pak3",
        "symbol": "PAK3",
        "name": "p21 (RAC1) activated kinase 3",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/pak3"
      },
      {
        "slug": "pcdh19",
        "symbol": "PCDH19",
        "name": "protocadherin 19",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/pcdh19"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}