{
  "url": "https://dantelabs.com/el/genes/h4c11",
  "gene": {
    "slug": "h4c11",
    "symbol": "H4C11",
    "name": "H4 clustered histone 11",
    "hgnc": "HGNC:4785",
    "summary": null,
    "location": "6p22.1",
    "locusType": "gene with protein product",
    "aliases": [
      "H4/e",
      "H4F2iv"
    ],
    "previousSymbols": [
      "H4FE",
      "HIST1H4J"
    ],
    "ensemblId": "ENSG00000197238",
    "entrezId": 8363,
    "omim": [
      "602826"
    ],
    "uniprot": [
      "P62805"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "6",
      "start": 27824092,
      "end": 27824480,
      "strand": "+",
      "ensemblTranscript": "ENST00000355057.3",
      "refseqTranscript": "NM_021968.4",
      "ensemblProtein": "ENSP00000347168.2",
      "refseqProtein": "NP_068803.1",
      "exons": [
        {
          "start": 27824092,
          "end": 27824480
        }
      ],
      "cds": {
        "start": 27824125,
        "end": 27824436
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "6",
      "start": 27791884,
      "end": 27792257,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 27324286,
      "end": 28324285,
      "genes": [
        {
          "symbol": "ZNF391",
          "ensemblId": "ENSG00000124613",
          "biotype": "protein_coding",
          "start": 27374615,
          "end": 27405026,
          "strand": "+",
          "slug": "znf391"
        },
        {
          "symbol": "ZNF184",
          "ensemblId": "ENSG00000096654",
          "biotype": "protein_coding",
          "start": 27449021,
          "end": 27473141,
          "strand": "-",
          "slug": "znf184"
        },
        {
          "symbol": "H2BC13",
          "ensemblId": "ENSG00000185130",
          "biotype": "protein_coding",
          "start": 27805409,
          "end": 27807936,
          "strand": "-",
          "slug": "h2bc13"
        },
        {
          "symbol": "H2AC13",
          "ensemblId": "ENSG00000196747",
          "biotype": "protein_coding",
          "start": 27808173,
          "end": 27808667,
          "strand": "+",
          "slug": "h2ac13"
        },
        {
          "symbol": "H3C10",
          "ensemblId": "ENSG00000278828",
          "biotype": "protein_coding",
          "start": 27810051,
          "end": 27811300,
          "strand": "+",
          "slug": "h3c10"
        },
        {
          "symbol": "H2AC14",
          "ensemblId": "ENSG00000276368",
          "biotype": "protein_coding",
          "start": 27814302,
          "end": 27814777,
          "strand": "-",
          "slug": "h2ac14"
        },
        {
          "symbol": "H2BC14",
          "ensemblId": "ENSG00000273703",
          "biotype": "protein_coding",
          "start": 27815022,
          "end": 27815489,
          "strand": "+",
          "slug": "h2bc14"
        },
        {
          "symbol": "H4C12",
          "ensemblId": "ENSG00000273542",
          "biotype": "protein_coding",
          "start": 27830918,
          "end": 27831560,
          "strand": "-",
          "slug": "h4c12"
        },
        {
          "symbol": "H2AC15",
          "ensemblId": "ENSG00000275221",
          "biotype": "protein_coding",
          "start": 27835508,
          "end": 27838375,
          "strand": "-",
          "slug": "h2ac15"
        },
        {
          "symbol": "H2BC15",
          "ensemblId": "ENSG00000233822",
          "biotype": "protein_coding",
          "start": 27838545,
          "end": 27855879,
          "strand": "+",
          "slug": "h2bc15"
        },
        {
          "symbol": "H2AC16",
          "ensemblId": "ENSG00000276903",
          "biotype": "protein_coding",
          "start": 27865317,
          "end": 27865798,
          "strand": "+",
          "slug": "h2ac16"
        },
        {
          "symbol": "H1-5",
          "ensemblId": "ENSG00000184357",
          "biotype": "protein_coding",
          "start": 27866792,
          "end": 27867588,
          "strand": "-",
          "slug": "h1-5"
        },
        {
          "symbol": "H3C11",
          "ensemblId": "ENSG00000275379",
          "biotype": "protein_coding",
          "start": 27871845,
          "end": 27872346,
          "strand": "-",
          "slug": "h3c11"
        },
        {
          "symbol": "H4C13",
          "ensemblId": "ENSG00000275126",
          "biotype": "protein_coding",
          "start": 27873148,
          "end": 27873534,
          "strand": "-",
          "slug": "h4c13"
        },
        {
          "symbol": "H3C12",
          "ensemblId": "ENSG00000197153",
          "biotype": "protein_coding",
          "start": 27890315,
          "end": 27893106,
          "strand": "-",
          "slug": "h3c12"
        },
        {
          "symbol": "H2AC17",
          "ensemblId": "ENSG00000278677",
          "biotype": "protein_coding",
          "start": 27892699,
          "end": 27893185,
          "strand": "-",
          "slug": "h2ac17"
        },
        {
          "symbol": "H2BC17",
          "ensemblId": "ENSG00000274641",
          "biotype": "protein_coding",
          "start": 27893425,
          "end": 27893891,
          "strand": "+",
          "slug": "h2bc17"
        },
        {
          "symbol": "OR2B2",
          "ensemblId": "ENSG00000168131",
          "biotype": "protein_coding",
          "start": 27911185,
          "end": 27912396,
          "strand": "-",
          "slug": "or2b2"
        },
        {
          "symbol": "OR2B6",
          "ensemblId": "ENSG00000124657",
          "biotype": "protein_coding",
          "start": 27957241,
          "end": 27958182,
          "strand": "+",
          "slug": "or2b6"
        },
        {
          "symbol": "OR2B8",
          "ensemblId": "ENSG00000182477",
          "biotype": "protein_coding",
          "start": 28053228,
          "end": 28054165,
          "strand": "-",
          "slug": "or2b8"
        },
        {
          "symbol": "ZNF165",
          "ensemblId": "ENSG00000197279",
          "biotype": "protein_coding",
          "start": 28080276,
          "end": 28089563,
          "strand": "+",
          "slug": "znf165"
        },
        {
          "symbol": "ZSCAN16",
          "ensemblId": "ENSG00000196812",
          "biotype": "protein_coding",
          "start": 28107681,
          "end": 28131659,
          "strand": "+",
          "slug": "zscan16"
        },
        {
          "symbol": "ZKSCAN8",
          "ensemblId": "ENSG00000198315",
          "biotype": "protein_coding",
          "start": 28141732,
          "end": 28160205,
          "strand": "+",
          "slug": "zkscan8"
        },
        {
          "symbol": "ZKSCAN8P1",
          "ensemblId": "ENSG00000226314",
          "biotype": "protein_coding",
          "start": 28161756,
          "end": 28170549,
          "strand": "+",
          "slug": "zkscan8p1"
        },
        {
          "symbol": "ZSCAN9",
          "ensemblId": "ENSG00000137185",
          "biotype": "protein_coding",
          "start": 28224886,
          "end": 28233487,
          "strand": "+",
          "slug": "zscan9"
        },
        {
          "symbol": "ZKSCAN4",
          "ensemblId": "ENSG00000187626",
          "biotype": "protein_coding",
          "start": 28241011,
          "end": 28252924,
          "strand": "-",
          "slug": "zkscan4"
        },
        {
          "symbol": "NKAPL",
          "ensemblId": "ENSG00000189134",
          "biotype": "protein_coding",
          "start": 28259297,
          "end": 28260958,
          "strand": "+",
          "slug": "nkapl"
        },
        {
          "symbol": "ZSCAN26",
          "ensemblId": "ENSG00000197062",
          "biotype": "protein_coding",
          "start": 28267045,
          "end": 28278224,
          "strand": "+",
          "slug": "zscan26"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000276302",
          "biotype": "protein_coding",
          "start": 28267121,
          "end": 28281580,
          "strand": "+"
        },
        {
          "symbol": "PGBD1",
          "ensemblId": "ENSG00000137338",
          "biotype": "protein_coding",
          "start": 28281488,
          "end": 28303691,
          "strand": "+",
          "slug": "pgbd1"
        },
        {
          "symbol": "ZSCAN31",
          "ensemblId": "ENSG00000235109",
          "biotype": "protein_coding",
          "start": 28312837,
          "end": 28356271,
          "strand": "-",
          "slug": "zscan31"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "absent-speech",
        "name": "Absent speech development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/absent-speech"
      },
      {
        "slug": "autistic-behavior",
        "name": "Autism spectrum disorder",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/autistic-behavior"
      },
      {
        "slug": "delayed-speech-and-language-development",
        "name": "Delayed speech and language development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/delayed-speech-and-language-development"
      },
      {
        "slug": "depressed-nasal-bridge",
        "name": "Depressed nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/depressed-nasal-bridge"
      },
      {
        "slug": "downturned-corners-of-mouth",
        "name": "Downturned corners of mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/downturned-corners-of-mouth"
      },
      {
        "slug": "pes-planus",
        "name": "Dropped arches",
        "systems": [
          "abnormality-of-limbs"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pes-planus"
      },
      {
        "slug": "periorbital-fullness",
        "name": "Fullness around the eyes",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/periorbital-fullness"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "growth-delay",
        "name": "Growth delay",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/growth-delay"
      },
      {
        "slug": "highly-arched-eyebrow",
        "name": "Highly arched eyebrow",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/highly-arched-eyebrow"
      },
      {
        "slug": "hypospadias",
        "name": "Hypospadias",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypospadias"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "esotropia",
        "name": "Inward turning cross eyed",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/esotropia"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "skeletal-muscle-atrophy",
        "name": "Muscle degeneration",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/skeletal-muscle-atrophy"
      },
      {
        "slug": "oculomotor-apraxia",
        "name": "Oculomotor apraxia",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/oculomotor-apraxia"
      },
      {
        "slug": "short-philtrum",
        "name": "Short philtrum",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-philtrum"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "upslanted-palpebral-fissure",
        "name": "Upward slanting of the opening between the eyelids",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/upslanted-palpebral-fissure"
      },
      {
        "slug": "wide-mouth",
        "name": "Wide mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/wide-mouth"
      },
      {
        "slug": "hypertelorism",
        "name": "Wide-set eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypertelorism"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}