{
  "url": "https://dantelabs.com/el/genes/dlc1",
  "gene": {
    "slug": "dlc1",
    "symbol": "DLC1",
    "name": "DLC1 Rho GTPase activating protein",
    "hgnc": "HGNC:2897",
    "summary": null,
    "location": "8p22",
    "locusType": "gene with protein product",
    "aliases": [
      "HP",
      "ARHGAP7",
      "STARD12",
      "DLC-1",
      "p122-RhoGAP"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000164741",
    "entrezId": 10395,
    "omim": [
      "604258"
    ],
    "uniprot": [
      "Q96QB1"
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    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "8",
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      "strand": "-",
      "ensemblTranscript": "ENST00000276297.9",
      "refseqTranscript": "NM_182643.3",
      "ensemblProtein": "ENSP00000276297.4",
      "refseqProtein": "NP_872584.2",
      "exons": [
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      ],
      "cds": {
        "start": 13085811,
        "end": 13500071
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "8",
      "start": 12940870,
      "end": 13373167,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 12651870,
      "end": 13946342,
      "genes": [
        {
          "symbol": "LONRF1",
          "ensemblId": "ENSG00000154359",
          "biotype": "protein_coding",
          "start": 12721897,
          "end": 12756073,
          "strand": "-",
          "slug": "lonrf1"
        },
        {
          "symbol": "TRMT9B",
          "ensemblId": "ENSG00000250305",
          "biotype": "protein_coding",
          "start": 12945642,
          "end": 13031503,
          "strand": "+",
          "slug": "trmt9b"
        },
        {
          "symbol": "C8orf48",
          "ensemblId": "ENSG00000164743",
          "biotype": "protein_coding",
          "start": 13566869,
          "end": 13568288,
          "strand": "+",
          "slug": "c8orf48"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "nephrotic-syndrome",
        "name": "Νεφρωτικό σύνδρομο",
        "diseases": [
          {
            "mondoId": "MONDO:0002331",
            "name": "Νεφρωση",
            "genes": 29,
            "inheritance": null,
            "description": "Παθολογικές διεργασίες του ΝΕΦΡΟΥ χωρίς φλεγμονώδεις ή νεοπλασματικές συνιστώσες. Η νεφρωση μπορεί να είναι πρωτοπαθής διαταραχή ή δευτεροπαθής επιπλοκή άλλων νοσημάτων. Χαρακτηρίζεται από το ΝΕΦΡΩΤΙΚΟ ΣΥΝΔΡΟΜΟ, το οποίο υποδηλώνει την παρουσία ΠΡΩΤΕΪΝΟΥΡΙΑΣ και ΥΠΟΑΛΒΟΥΜΙΝΑΙΜΙΑΣ με συνοδό ΟΙΔΗΜΑ.",
            "management": null,
            "evidence": {
              "gencc": [
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/nephrotic-syndrome"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "renal-cell-carcinoma",
        "name": "Cancer starting in small tubes in kidneys",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/renal-cell-carcinoma"
      },
      {
        "slug": "colon-cancer",
        "name": "Colon cancer",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/colon-cancer"
      },
      {
        "slug": "hereditary-nonpolyposis-colorectal-carcinoma",
        "name": "Hereditary nonpolyposis colorectal carcinoma",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/hereditary-nonpolyposis-colorectal-carcinoma"
      },
      {
        "slug": "neoplasm-of-the-stomach",
        "name": "Stomach tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/neoplasm-of-the-stomach"
      },
      {
        "slug": "transitional-cell-carcinoma-of-the-bladder",
        "name": "Transitional cell carcinoma of the bladder",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/transitional-cell-carcinoma-of-the-bladder"
      },
      {
        "slug": "uterine-leiomyosarcoma",
        "name": "Uterine leiomyosarcoma",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/uterine-leiomyosarcoma"
      }
    ],
    "related": [
      {
        "slug": "actn4",
        "symbol": "ACTN4",
        "name": "actinin alpha 4",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/actn4"
      },
      {
        "slug": "arhgdia",
        "symbol": "ARHGDIA",
        "name": "Rho GDP dissociation inhibitor alpha",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/arhgdia"
      },
      {
        "slug": "coq6",
        "symbol": "COQ6",
        "name": "coenzyme Q6, monooxygenase",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/coq6"
      },
      {
        "slug": "coq8b",
        "symbol": "COQ8B",
        "name": "coenzyme Q8B",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/coq8b"
      },
      {
        "slug": "daam2",
        "symbol": "DAAM2",
        "name": "dishevelled associated activator of morphogenesis 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/daam2"
      },
      {
        "slug": "dgke",
        "symbol": "DGKE",
        "name": "diacylglycerol kinase epsilon",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/dgke"
      },
      {
        "slug": "emp2",
        "symbol": "EMP2",
        "name": "epithelial membrane protein 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/emp2"
      },
      {
        "slug": "itsn1",
        "symbol": "ITSN1",
        "name": "intersectin 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/itsn1"
      },
      {
        "slug": "itsn2",
        "symbol": "ITSN2",
        "name": "intersectin 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/itsn2"
      },
      {
        "slug": "kank2",
        "symbol": "KANK2",
        "name": "KN motif and ankyrin repeat domains 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/kank2"
      },
      {
        "slug": "lama5",
        "symbol": "LAMA5",
        "name": "laminin subunit alpha 5",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/lama5"
      },
      {
        "slug": "lamb2",
        "symbol": "LAMB2",
        "name": "laminin subunit beta 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/lamb2"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}