{
  "url": "https://dantelabs.com/el/genes/cyp7a1",
  "gene": {
    "slug": "cyp7a1",
    "symbol": "CYP7A1",
    "name": "cytochrome P450 family 7 subfamily A member 1",
    "hgnc": "HGNC:2651",
    "summary": null,
    "location": "8q12.1",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
      "CYP7"
    ],
    "ensemblId": "ENSG00000167910",
    "entrezId": 1581,
    "omim": [
      "118455"
    ],
    "uniprot": [
      "P22680"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "8",
      "start": 58490178,
      "end": 58500163,
      "strand": "-",
      "ensemblTranscript": "ENST00000301645.4",
      "refseqTranscript": "NM_000780.4",
      "ensemblProtein": "ENSP00000301645.3",
      "refseqProtein": "NP_000771.2",
      "exons": [
        {
          "start": 58490178,
          "end": 58491774
        },
        {
          "start": 58492353,
          "end": 58492528
        },
        {
          "start": 58494506,
          "end": 58494636
        },
        {
          "start": 58496604,
          "end": 58497190
        },
        {
          "start": 58498229,
          "end": 58498469
        },
        {
          "start": 58500019,
          "end": 58500163
        }
      ],
      "cds": {
        "start": 58491475,
        "end": 58500098
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "8",
      "start": 59402737,
      "end": 59412795,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 57995171,
      "end": 58995170,
      "genes": [
        {
          "symbol": "FAM110B",
          "ensemblId": "ENSG00000169122",
          "biotype": "protein_coding",
          "start": 57993956,
          "end": 58204279,
          "strand": "+",
          "slug": "fam110b"
        },
        {
          "symbol": "UBXN2B",
          "ensemblId": "ENSG00000215114",
          "biotype": "protein_coding",
          "start": 58411348,
          "end": 58453627,
          "strand": "+",
          "slug": "ubxn2b"
        },
        {
          "symbol": "SDCBP",
          "ensemblId": "ENSG00000137575",
          "biotype": "protein_coding",
          "start": 58552924,
          "end": 58584380,
          "strand": "+",
          "slug": "sdcbp"
        },
        {
          "symbol": "NSMAF",
          "ensemblId": "ENSG00000035681",
          "biotype": "protein_coding",
          "start": 58582788,
          "end": 58659997,
          "strand": "-",
          "slug": "nsmaf"
        },
        {
          "symbol": "TOX",
          "ensemblId": "ENSG00000198846",
          "biotype": "protein_coding",
          "start": 58805412,
          "end": 59119310,
          "strand": "-",
          "slug": "tox"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-circulating-vitamin-a-concentration",
        "name": "Abnormal circulating vitamin A concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-circulating-vitamin-a-concentration"
      },
      {
        "slug": "abnormal-circulating-vitamin-e-concentration",
        "name": "Abnormal circulating vitamin E concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-circulating-vitamin-e-concentration"
      },
      {
        "slug": "accelerated-atherosclerosis",
        "name": "Accelerated plaque build-up in arteries",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/accelerated-atherosclerosis"
      },
      {
        "slug": "acute-hepatic-steatosis",
        "name": "Acute fatty liver",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/acute-hepatic-steatosis"
      },
      {
        "slug": "aortic-atherosclerotic-lesion",
        "name": "Aortic atherosclerotic lesion",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/aortic-atherosclerotic-lesion"
      },
      {
        "slug": "cholesterol-gallstones",
        "name": "Cholesterol gallstones",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/cholesterol-gallstones"
      },
      {
        "slug": "hypercholesterolemia",
        "name": "Elevated serum cholesterol",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypercholesterolemia"
      },
      {
        "slug": "hepatic-steatosis",
        "name": "Fatty infiltration of liver",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hepatic-steatosis"
      },
      {
        "slug": "elevated-circulating-ldl-c-concentration",
        "name": "Increased circulating LDL level",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/elevated-circulating-ldl-c-concentration"
      },
      {
        "slug": "hypertriglyceridemia",
        "name": "Increased plasma triglycerides",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypertriglyceridemia"
      },
      {
        "slug": "hepatitis",
        "name": "Liver inflammation",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hepatitis"
      },
      {
        "slug": "macrovesicular-hepatic-steatosis",
        "name": "Macrovesicular hepatic steatosis",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/macrovesicular-hepatic-steatosis"
      },
      {
        "slug": "obesity",
        "name": "Obesity",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/obesity"
      },
      {
        "slug": "coronary-artery-atherosclerosis",
        "name": "Plaque build-up in arteries supplying blood to heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/coronary-artery-atherosclerosis"
      },
      {
        "slug": "cholestasis",
        "name": "Slowed or blocked flow of bile from liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/cholestasis"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}