{
  "url": "https://dantelabs.com/el/genes/clcnkb",
  "gene": {
    "slug": "clcnkb",
    "symbol": "CLCNKB",
    "name": "chloride voltage-gated channel Kb",
    "hgnc": "HGNC:2027",
    "summary": null,
    "location": "1p36.13",
    "locusType": "gene with protein product",
    "aliases": [
      "hClC-Kb",
      "CLCKB",
      "ClC-K2",
      "ClC-Kb"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000184908",
    "entrezId": 1188,
    "omim": [
      "602023"
    ],
    "uniprot": [
      "P51801"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "1",
      "start": 16043782,
      "end": 16057308,
      "strand": "+",
      "ensemblTranscript": "ENST00000375679.9",
      "refseqTranscript": "NM_000085.5",
      "ensemblProtein": "ENSP00000364831.5",
      "refseqProtein": "NP_000076.2",
      "exons": [
        {
          "start": 16043782,
          "end": 16043880
        },
        {
          "start": 16044486,
          "end": 16044592
        },
        {
          "start": 16045558,
          "end": 16045686
        },
        {
          "start": 16046535,
          "end": 16046663
        },
        {
          "start": 16047905,
          "end": 16048044
        },
        {
          "start": 16048343,
          "end": 16048420
        },
        {
          "start": 16048504,
          "end": 16048582
        },
        {
          "start": 16049120,
          "end": 16049245
        },
        {
          "start": 16049618,
          "end": 16049702
        },
        {
          "start": 16049815,
          "end": 16049916
        },
        {
          "start": 16050516,
          "end": 16050600
        },
        {
          "start": 16050875,
          "end": 16051048
        },
        {
          "start": 16051478,
          "end": 16051547
        },
        {
          "start": 16051710,
          "end": 16051820
        },
        {
          "start": 16052198,
          "end": 16052411
        },
        {
          "start": 16053639,
          "end": 16053772
        },
        {
          "start": 16055435,
          "end": 16055523
        },
        {
          "start": 16055675,
          "end": 16055758
        },
        {
          "start": 16056422,
          "end": 16056508
        },
        {
          "start": 16056869,
          "end": 16057308
        }
      ],
      "cds": {
        "start": 16044493,
        "end": 16056916
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "1",
      "start": 16370272,
      "end": 16383803,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 15550545,
      "end": 16550544,
      "genes": [
        {
          "symbol": "DNAJC16",
          "ensemblId": "ENSG00000116138",
          "biotype": "protein_coding",
          "start": 15526813,
          "end": 15592379,
          "strand": "+",
          "slug": "dnajc16"
        },
        {
          "symbol": "AGMAT",
          "ensemblId": "ENSG00000116771",
          "biotype": "protein_coding",
          "start": 15571699,
          "end": 15585084,
          "strand": "-",
          "slug": "agmat"
        },
        {
          "symbol": "DDI2",
          "ensemblId": "ENSG00000197312",
          "biotype": "protein_coding",
          "start": 15617416,
          "end": 15669044,
          "strand": "+",
          "slug": "ddi2"
        },
        {
          "symbol": "RSC1A1",
          "ensemblId": "ENSG00000215695",
          "biotype": "protein_coding",
          "start": 15659713,
          "end": 15662033,
          "strand": "+"
        },
        {
          "symbol": "PLEKHM2",
          "ensemblId": "ENSG00000116786",
          "biotype": "protein_coding",
          "start": 15681461,
          "end": 15734771,
          "strand": "+",
          "slug": "plekhm2"
        },
        {
          "symbol": "SLC25A34",
          "ensemblId": "ENSG00000162461",
          "biotype": "protein_coding",
          "start": 15736176,
          "end": 15741392,
          "strand": "+",
          "slug": "slc25a34"
        },
        {
          "symbol": "TMEM82",
          "ensemblId": "ENSG00000162460",
          "biotype": "protein_coding",
          "start": 15742488,
          "end": 15747982,
          "strand": "+",
          "slug": "tmem82"
        },
        {
          "symbol": "FBLIM1",
          "ensemblId": "ENSG00000162458",
          "biotype": "protein_coding",
          "start": 15756604,
          "end": 15786594,
          "strand": "+",
          "slug": "fblim1"
        },
        {
          "symbol": "UQCRHL",
          "ensemblId": "ENSG00000233954",
          "biotype": "protein_coding",
          "start": 15807169,
          "end": 15809348,
          "strand": "-",
          "slug": "uqcrhl"
        },
        {
          "symbol": "SPEN",
          "ensemblId": "ENSG00000065526",
          "biotype": "protein_coding",
          "start": 15836095,
          "end": 15940456,
          "strand": "+",
          "slug": "spen"
        },
        {
          "symbol": "ZBTB17",
          "ensemblId": "ENSG00000116809",
          "biotype": "protein_coding",
          "start": 15940148,
          "end": 15976132,
          "strand": "-",
          "slug": "zbtb17"
        },
        {
          "symbol": "SRARP",
          "ensemblId": "ENSG00000183888",
          "biotype": "protein_coding",
          "start": 16004229,
          "end": 16009382,
          "strand": "+",
          "slug": "srarp"
        },
        {
          "symbol": "HSPB7",
          "ensemblId": "ENSG00000173641",
          "biotype": "protein_coding",
          "start": 16014018,
          "end": 16020597,
          "strand": "-",
          "slug": "hspb7"
        },
        {
          "symbol": "CLCNKA",
          "ensemblId": "ENSG00000186510",
          "biotype": "protein_coding",
          "start": 16018146,
          "end": 16034109,
          "strand": "+",
          "slug": "clcnka"
        },
        {
          "symbol": "FAM131C",
          "ensemblId": "ENSG00000185519",
          "biotype": "protein_coding",
          "start": 16057769,
          "end": 16073664,
          "strand": "-",
          "slug": "fam131c"
        },
        {
          "symbol": "EPHA2",
          "ensemblId": "ENSG00000142627",
          "biotype": "protein_coding",
          "start": 16124337,
          "end": 16156141,
          "strand": "-",
          "slug": "epha2"
        },
        {
          "symbol": "ARHGEF19",
          "ensemblId": "ENSG00000142632",
          "biotype": "protein_coding",
          "start": 16197854,
          "end": 16212893,
          "strand": "-",
          "slug": "arhgef19"
        },
        {
          "symbol": "CPLANE2",
          "ensemblId": "ENSG00000132881",
          "biotype": "protein_coding",
          "start": 16231692,
          "end": 16237214,
          "strand": "-",
          "slug": "cplane2"
        },
        {
          "symbol": "FBXO42",
          "ensemblId": "ENSG00000037637",
          "biotype": "protein_coding",
          "start": 16246840,
          "end": 16352494,
          "strand": "-",
          "slug": "fbxo42"
        },
        {
          "symbol": "SZRD1",
          "ensemblId": "ENSG00000055070",
          "biotype": "protein_coding",
          "start": 16352575,
          "end": 16398147,
          "strand": "+",
          "slug": "szrd1"
        },
        {
          "symbol": "SPATA21",
          "ensemblId": "ENSG00000187144",
          "biotype": "protein_coding",
          "start": 16387117,
          "end": 16437424,
          "strand": "-",
          "slug": "spata21"
        },
        {
          "symbol": "NECAP2",
          "ensemblId": "ENSG00000157191",
          "biotype": "protein_coding",
          "start": 16440664,
          "end": 16460092,
          "strand": "+",
          "slug": "necap2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "bartter-disease",
        "name": "Σύνδρομο Bartter",
        "diseases": [
          {
            "mondoId": "MONDO:0011822",
            "name": "Σύνδρομο Bartter τύπου 3",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Το κλασικό σύνδρομο Bartter είναι ένας τύπος συνδρόμου Bartter, που χαρακτηρίζεται από ηπιότερη κλινική εικόνα σε σύγκριση με τον προγεννητικό/βρεφικό υποτύπο, και εκδηλώνεται με καθυστέρηση ανάπτυξης, υποκαλιαιμική αλκάλωση, αυξημένα επίπεδα ρενίνης και αλδοστερόνης στο πλάσμα, χαμηλή αρτηριακή πίεση και αντίσταση των αγγείων στην αγγειοτενσίνη II.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "Natera"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0019524",
            "name": "Σύνδρομο Bartter τύπου 4",
            "genes": 2,
            "inheritance": "autosomal-recessive",
            "description": "Μορφή συνδρόμου Bartter που χαρακτηρίζεται από μητρική πολυϋδράμνιο, πρόωρο τοκετό, απώλεια αλατιού, πολυουρία και νευροαισθητηριακή κώφωση, σε συνδυασμό με υποκαλιαιμική και υποχλωριαιμική μεταβολική αλκάλωση, αυξημένα επίπεδα ρενίνης και αλδοστερόνης στο πλάσμα και χαμηλή έως φυσιολογική αρτηριακή πίεση. Τα ποσοστά αποβολής ασβεστίου στα ούρα είναι μεταβλητά, και συνήθως απουσιάζει η νεφρασβέστωση.",
            "management": null,
            "evidence": {
              "gencc": [
                "G2P",
                "Natera"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0015231",
            "name": "Σύνδρομο Bartter",
            "genes": 5,
            "inheritance": null,
            "description": "Μια ομάδα κληρονομικών διαταραχών των νεφρικών σωληναρίων που προκαλούν απώλεια άλατος, οφειλόμενων σε γονίδια όπως τα SLC12A1, KCNJ1, CLCNKB, BSND και CASR, με χαμηλό κάλιο, μεταβολική αλκάλωση και υψηλό ασβέστιο στα ούρα.",
            "management": "Η γνώση αυτή καθοδηγεί την αναπλήρωση άλατος και καλίου, καθώς και την παρακολούθηση της ανάπτυξης και της νεφρικής ασβεστίωσης.",
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "Natera"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/bartter-disease"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "abnormal-choroid-morphology",
        "name": "Abnormal choroid morphology",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/abnormal-choroid-morphology"
      },
      {
        "slug": "cerebral-calcification",
        "name": "Abnormal deposits of calcium in the brain",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/cerebral-calcification"
      },
      {
        "slug": "abnormal-t-wave",
        "name": "Abnormal T-wave",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/abnormal-t-wave"
      },
      {
        "slug": "abnormal-retinal-vascular-morphology",
        "name": "Abnormality of retina blood vessels",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/abnormal-retinal-vascular-morphology"
      },
      {
        "slug": "abnormal-sclera-morphology",
        "name": "Abnormality of the outer white part of eyeball",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/abnormal-sclera-morphology"
      },
      {
        "slug": "renal-tubular-acidosis",
        "name": "Accumulation of acid in body due to kidney problem",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/renal-tubular-acidosis"
      },
      {
        "slug": "acute-kidney-injury",
        "name": "Acute kidney injury",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/acute-kidney-injury"
      },
      {
        "slug": "bilateral-sensorineural-hearing-impairment",
        "name": "Bilateral sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/bilateral-sensorineural-hearing-impairment"
      },
      {
        "slug": "blurred-vision",
        "name": "Blurred vision",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/blurred-vision"
      },
      {
        "slug": "insulin-resistance",
        "name": "Body fails to respond to insulin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/insulin-resistance"
      },
      {
        "slug": "rhabdomyolysis",
        "name": "Breakdown of skeletal muscle",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/rhabdomyolysis"
      },
      {
        "slug": "respiratory-distress",
        "name": "Breathing difficulties",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/respiratory-distress"
      },
      {
        "slug": "chondrocalcinosis",
        "name": "Calcium deposits in joints",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/chondrocalcinosis"
      },
      {
        "slug": "emotional-lability",
        "name": "Can't control feelings",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/emotional-lability"
      },
      {
        "slug": "neoplasm-of-the-pancreas",
        "name": "Cancer of the pancreas",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-pancreas"
      },
      {
        "slug": "chronic-kidney-disease",
        "name": "Chronic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chronic-kidney-disease"
      },
      {
        "slug": "clumsiness",
        "name": "Clumsiness",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/clumsiness"
      },
      {
        "slug": "constipation",
        "name": "Constipation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/constipation"
      },
      {
        "slug": "decreased-glomerular-filtration-rate",
        "name": "Decreased glomerular filtration rate",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/decreased-glomerular-filtration-rate"
      },
      {
        "slug": "hyporeflexia",
        "name": "Decreased reflex response",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/hyporeflexia"
      },
      {
        "slug": "decreased-urinary-potassium",
        "name": "Decreased urinary potassium",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/decreased-urinary-potassium"
      },
      {
        "slug": "dehydration",
        "name": "Dehydration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dehydration"
      },
      {
        "slug": "delayed-ability-to-stand",
        "name": "Delayed ability to stand",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-ability-to-stand"
      },
      {
        "slug": "delayed-ability-to-walk",
        "name": "Delayed ability to walk",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-ability-to-walk"
      },
      {
        "slug": "delayed-puberty",
        "name": "Delayed puberty",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/delayed-puberty"
      },
      {
        "slug": "diabetic-ketoacidosis",
        "name": "Diabetic ketoacidosis",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/diabetic-ketoacidosis"
      },
      {
        "slug": "diarrhea",
        "name": "Diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/diarrhea"
      },
      {
        "slug": "insomnia",
        "name": "Difficulty staying or falling asleep",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/insomnia"
      },
      {
        "slug": "vertigo",
        "name": "Dizziness",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/vertigo"
      },
      {
        "slug": "increased-circulating-renin-concentration",
        "name": "Elevated blood renin level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-renin-concentration"
      },
      {
        "slug": "increased-circulating-aldosterone-concentration",
        "name": "Elevated plasma aldosterone",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-aldosterone-concentration"
      },
      {
        "slug": "hypercalciuria",
        "name": "Elevated urine calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypercalciuria"
      },
      {
        "slug": "enuresis",
        "name": "Enuresis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/enuresis"
      },
      {
        "slug": "excessive-daytime-somnolence",
        "name": "Excessive daytime sleepiness",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/excessive-daytime-somnolence"
      },
      {
        "slug": "hyperhidrosis",
        "name": "Excessive sweating",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hyperhidrosis"
      },
      {
        "slug": "polydipsia",
        "name": "Extreme thirst",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/polydipsia"
      },
      {
        "slug": "syncope",
        "name": "Fainting spell",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/syncope"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "fetal-polyuria",
        "name": "Fetal polyuria",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "url": "https://dantelabs.com/traits/fetal-polyuria"
      },
      {
        "slug": "pericardial-effusion",
        "name": "Fluid around heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/pericardial-effusion"
      },
      {
        "slug": "edema",
        "name": "Fluid retention",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/edema"
      },
      {
        "slug": "focal-segmental-glomerulosclerosis",
        "name": "Focal segmental glomerulosclerosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/focal-segmental-glomerulosclerosis"
      },
      {
        "slug": "generalized-hypotonia",
        "name": "Generalized decreased muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/generalized-hypotonia"
      },
      {
        "slug": "generalized-muscle-weakness",
        "name": "Generalized muscle weakness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/generalized-muscle-weakness"
      },
      {
        "slug": "glucose-intolerance",
        "name": "Glucose intolerance",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/glucose-intolerance"
      },
      {
        "slug": "gout",
        "name": "Gout",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/gout"
      },
      {
        "slug": "graves-disease",
        "name": "Graves disease",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/graves-disease"
      },
      {
        "slug": "hashimoto-thyroiditis",
        "name": "Hashimoto thyroiditis",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hashimoto-thyroiditis"
      },
      {
        "slug": "headache",
        "name": "Headache",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/headache"
      },
      {
        "slug": "hypermagnesemia",
        "name": "High blood magnesium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypermagnesemia"
      },
      {
        "slug": "hypertension",
        "name": "High blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/hypertension"
      },
      {
        "slug": "polyhydramnios",
        "name": "High levels of amniotic fluid",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/polyhydramnios"
      },
      {
        "slug": "hyperprostaglandinuria",
        "name": "High urine prostaglandin levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperprostaglandinuria"
      },
      {
        "slug": "proteinuria",
        "name": "High urine protein levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/proteinuria"
      },
      {
        "slug": "hyperactive-renin-angiotensin-system",
        "name": "Hyperactive renin-angiotensin system",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hyperactive-renin-angiotensin-system"
      },
      {
        "slug": "hypernatriuria",
        "name": "Hypernatriuria",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/hypernatriuria"
      },
      {
        "slug": "hypokalemic-hypochloremic-metabolic-alkalosis",
        "name": "Hypokalemic hypochloremic metabolic alkalosis",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/hypokalemic-hypochloremic-metabolic-alkalosis"
      },
      {
        "slug": "hypokalemic-metabolic-alkalosis",
        "name": "Hypokalemic metabolic alkalosis",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypokalemic-metabolic-alkalosis"
      },
      {
        "slug": "impaired-renal-concentrating-ability",
        "name": "Impaired renal concentrating ability",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/impaired-renal-concentrating-ability"
      },
      {
        "slug": "impaired-renal-tubular-reabsorption-of-chloride",
        "name": "Impaired renal tubular reabsorption of chloride",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/impaired-renal-tubular-reabsorption-of-chloride"
      },
      {
        "slug": "nephrocalcinosis",
        "name": "Increased calcium level in kidney",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nephrocalcinosis"
      },
      {
        "slug": "hyperchloriduria",
        "name": "Increased urinary chloride",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/hyperchloriduria"
      },
      {
        "slug": "increased-urinary-potassium",
        "name": "Increased urinary potassium",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-urinary-potassium"
      },
      {
        "slug": "polyuria",
        "name": "Increased urine output",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/polyuria"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "iron-deficiency-anemia",
        "name": "Iron deficiency anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/iron-deficiency-anemia"
      },
      {
        "slug": "arthralgia",
        "name": "Joint pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/arthralgia"
      },
      {
        "slug": "urinary-incontinence",
        "name": "Loss of bladder control",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "constitutional-symptom"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/urinary-incontinence"
      },
      {
        "slug": "renal-salt-wasting",
        "name": "Loss of salt in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/renal-salt-wasting"
      },
      {
        "slug": "hypocalcemia",
        "name": "Low blood calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypocalcemia"
      },
      {
        "slug": "hypochloremia",
        "name": "Low blood chloride levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypochloremia"
      },
      {
        "slug": "hypomagnesemia",
        "name": "Low blood magnesium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypomagnesemia"
      },
      {
        "slug": "hypokalemia",
        "name": "Low blood potassium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypokalemia"
      },
      {
        "slug": "hypotension",
        "name": "Low blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/hypotension"
      },
      {
        "slug": "hyponatremia",
        "name": "Low blood sodium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyponatremia"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "hypocalciuria",
        "name": "Low urine calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypocalciuria"
      },
      {
        "slug": "low-to-normal-blood-pressure",
        "name": "Low-to-normal blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/low-to-normal-blood-pressure"
      },
      {
        "slug": "metabolic-alkalosis",
        "name": "Metabolic alkalosis",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/metabolic-alkalosis"
      },
      {
        "slug": "mitochondrial-encephalopathy",
        "name": "Mitochondrial encephalopathy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/mitochondrial-encephalopathy"
      },
      {
        "slug": "motor-delay",
        "name": "Motor delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/motor-delay"
      },
      {
        "slug": "myalgia",
        "name": "Muscle ache",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/myalgia"
      },
      {
        "slug": "muscle-spasm",
        "name": "Muscle spasm",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/muscle-spasm"
      },
      {
        "slug": "muscle-weakness",
        "name": "Muscle weakness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/muscle-weakness"
      },
      {
        "slug": "nasogastric-tube-feeding",
        "name": "Nasogastric tube feeding",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nasogastric-tube-feeding"
      },
      {
        "slug": "nausea-and-vomiting",
        "name": "Nausea and vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nausea-and-vomiting"
      },
      {
        "slug": "nocturia",
        "name": "Nocturia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nocturia"
      },
      {
        "slug": "type-ii-diabetes-mellitus",
        "name": "Noninsulin-dependent diabetes",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/type-ii-diabetes-mellitus"
      },
      {
        "slug": "palpitations",
        "name": "Palpitations",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/palpitations"
      },
      {
        "slug": "paralysis",
        "name": "Paralysis",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/paralysis"
      },
      {
        "slug": "parathyroid-adenoma",
        "name": "Parathyroid adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/parathyroid-adenoma"
      },
      {
        "slug": "paresthesia",
        "name": "Pins and needles feeling",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/paresthesia"
      },
      {
        "slug": "premature-birth",
        "name": "Premature birth",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/premature-birth"
      },
      {
        "slug": "primary-hyperaldosteronism",
        "name": "Primary hyperaldosteronism",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/primary-hyperaldosteronism"
      },
      {
        "slug": "prolonged-pr-interval",
        "name": "Prolonged PR interval",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/prolonged-pr-interval"
      },
      {
        "slug": "prolonged-qt-interval",
        "name": "Prolonged QT interval",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/prolonged-qt-interval"
      },
      {
        "slug": "protruding-ear",
        "name": "Prominent ear",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/protruding-ear"
      },
      {
        "slug": "prominent-u-wave",
        "name": "Prominent U wave",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/prominent-u-wave"
      },
      {
        "slug": "raynaud-phenomenon",
        "name": "Raynaud phenomenon",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/raynaud-phenomenon"
      },
      {
        "slug": "renal-insufficiency",
        "name": "Renal failure",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/renal-insufficiency"
      },
      {
        "slug": "renal-fanconi-syndrome",
        "name": "Renal Fanconi syndrome",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/renal-fanconi-syndrome"
      },
      {
        "slug": "renal-potassium-wasting",
        "name": "Renal potassium wasting",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-potassium-wasting"
      },
      {
        "slug": "tinnitus",
        "name": "Ringing in ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/tinnitus"
      },
      {
        "slug": "salt-craving",
        "name": "Salt craving",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/salt-craving"
      },
      {
        "slug": "scleroderma",
        "name": "Scleroderma",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/scleroderma"
      },
      {
        "slug": "focal-onset-seizure",
        "name": "Seizure affecting one half of brain",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/focal-onset-seizure"
      },
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "severe-failure-to-thrive",
        "name": "Severe faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/severe-failure-to-thrive"
      },
      {
        "slug": "small-for-gestational-age",
        "name": "Small for gestational age",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/small-for-gestational-age"
      },
      {
        "slug": "st-segment-depression",
        "name": "ST segment depression",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/st-segment-depression"
      },
      {
        "slug": "stage-5-chronic-kidney-disease",
        "name": "Stage 5 chronic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/stage-5-chronic-kidney-disease"
      },
      {
        "slug": "triangular-face",
        "name": "Triangular face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/triangular-face"
      },
      {
        "slug": "tubulointerstitial-nephritis",
        "name": "Tubulointerstitial nephritis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/tubulointerstitial-nephritis"
      },
      {
        "slug": "type-i-diabetes-mellitus",
        "name": "Type 1 diabetes",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/type-i-diabetes-mellitus"
      },
      {
        "slug": "varicose-veins",
        "name": "Varicose veins",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/varicose-veins"
      },
      {
        "slug": "ventricular-fibrillation",
        "name": "Ventricular fibrillation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/ventricular-fibrillation"
      },
      {
        "slug": "vomiting",
        "name": "Vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/vomiting"
      }
    ],
    "related": [
      {
        "slug": "bsnd",
        "symbol": "BSND",
        "name": "barttin CLCNK type accessory subunit beta",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/bsnd"
      },
      {
        "slug": "kcnj1",
        "symbol": "KCNJ1",
        "name": "potassium inwardly rectifying channel subfamily J member 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/kcnj1"
      },
      {
        "slug": "maged2",
        "symbol": "MAGED2",
        "name": "MAGE family member D2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/maged2"
      },
      {
        "slug": "slc12a1",
        "symbol": "SLC12A1",
        "name": "solute carrier family 12 member 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/slc12a1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}