{
  "url": "https://dantelabs.com/traits/vitreoretinopathy",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "vitreoretinopathy",
    "id": "HP:0007773",
    "name": "Vitreoretinopathy",
    "definition": "Ocular abnormality characterized by premature degeneration of the vitreous and the retina that may be associated with increased risk of retinal detachment.",
    "synonyms": [
      "Vitreoretinal abnormality",
      "Vitreoretinal degeneration"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-vitreous-humor-morphology",
        "name": "Abnormal vitreous humor morphology",
        "url": "https://dantelabs.com/traits/abnormal-vitreous-humor-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "exudative-vitreoretinopathy",
        "name": "Exudative vitreoretinopathy",
        "genes": 9,
        "url": "https://dantelabs.com/traits/exudative-vitreoretinopathy"
      },
      {
        "slug": "degenerative-vitreoretinopathy",
        "name": "Degenerative vitreoretinopathy",
        "genes": 5,
        "url": "https://dantelabs.com/traits/degenerative-vitreoretinopathy"
      },
      {
        "slug": "peripheral-vitreoretinal-degeneration",
        "name": "Peripheral vitreoretinal degeneration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/peripheral-vitreoretinal-degeneration"
      },
      {
        "slug": "snowflake-vitreoretinal-degeneration",
        "name": "Snowflake vitreoretinal degeneration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/snowflake-vitreoretinal-degeneration"
      }
    ],
    "genes": [
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "col9a2",
        "symbol": "COL9A2",
        "hgnc": "HGNC:2218",
        "name": "collagen type IX alpha 2 chain",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col9a2"
      },
      {
        "slug": "ctnnb1",
        "symbol": "CTNNB1",
        "hgnc": "HGNC:2514",
        "name": "catenin beta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnnb1"
      },
      {
        "slug": "fzd4",
        "symbol": "FZD4",
        "hgnc": "HGNC:4042",
        "name": "frizzled class receptor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fzd4"
      },
      {
        "slug": "lrp5",
        "symbol": "LRP5",
        "hgnc": "HGNC:6697",
        "name": "LDL receptor related protein 5",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lrp5"
      },
      {
        "slug": "ndp",
        "symbol": "NDP",
        "hgnc": "HGNC:7678",
        "name": "norrin cystine knot growth factor NDP",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndp"
      },
      {
        "slug": "pak2",
        "symbol": "PAK2",
        "hgnc": "HGNC:8591",
        "name": "p21 (RAC1) activated kinase 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pak2"
      },
      {
        "slug": "tspan12",
        "symbol": "TSPAN12",
        "hgnc": "HGNC:21641",
        "name": "tetraspanin 12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tspan12"
      },
      {
        "slug": "znf408",
        "symbol": "ZNF408",
        "hgnc": "HGNC:20041",
        "name": "zinc finger protein 408",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf408"
      },
      {
        "slug": "col18a1",
        "symbol": "COL18A1",
        "hgnc": "HGNC:2195",
        "name": "collagen type XVIII alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col18a1"
      },
      {
        "slug": "col11a1",
        "symbol": "COL11A1",
        "hgnc": "HGNC:2186",
        "name": "collagen type XI alpha 1 chain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col11a1"
      },
      {
        "slug": "col9a1",
        "symbol": "COL9A1",
        "hgnc": "HGNC:2217",
        "name": "collagen type IX alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col9a1"
      },
      {
        "slug": "col9a3",
        "symbol": "COL9A3",
        "hgnc": "HGNC:2219",
        "name": "collagen type IX alpha 3 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col9a3"
      },
      {
        "slug": "loxl3",
        "symbol": "LOXL3",
        "hgnc": "HGNC:13869",
        "name": "lysyl oxidase like 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/loxl3"
      },
      {
        "slug": "capn5",
        "symbol": "CAPN5",
        "hgnc": "HGNC:1482",
        "name": "calpain 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/capn5"
      },
      {
        "slug": "crb1",
        "symbol": "CRB1",
        "hgnc": "HGNC:2343",
        "name": "crumbs cell polarity complex component 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crb1"
      },
      {
        "slug": "nr2e3",
        "symbol": "NR2E3",
        "hgnc": "HGNC:7974",
        "name": "nuclear receptor subfamily 2 group E member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr2e3"
      },
      {
        "slug": "vcan",
        "symbol": "VCAN",
        "hgnc": "HGNC:2464",
        "name": "versican",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vcan"
      }
    ]
  }
}