{
  "url": "https://dantelabs.com/traits/stratum-basale-cleavage",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "stratum-basale-cleavage",
    "id": "HP:0034193",
    "name": "Stratum basale cleavage",
    "definition": "Cleavage within the epidermal keratinocytes, which is the innermost layer of the epidermis and consists of proliferating cells that give rise to the outer layers of the epidermis.",
    "synonyms": [
      "Blistering with cleavage within basal keratinocytes",
      "Cleavage within the basal keratinocyte layer"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "intra-epidermal-blistering",
        "name": "Intra-epidermal blistering",
        "url": "https://dantelabs.com/traits/intra-epidermal-blistering"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "itgb4",
        "symbol": "ITGB4",
        "hgnc": "HGNC:6158",
        "name": "integrin subunit beta 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb4"
      },
      {
        "slug": "krt14",
        "symbol": "KRT14",
        "hgnc": "HGNC:6416",
        "name": "keratin 14",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/krt14"
      },
      {
        "slug": "krt5",
        "symbol": "KRT5",
        "hgnc": "HGNC:6442",
        "name": "keratin 5",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt5"
      },
      {
        "slug": "plec",
        "symbol": "PLEC",
        "hgnc": "HGNC:9069",
        "name": "plectin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plec"
      }
    ]
  }
}