{
  "url": "https://dantelabs.com/traits/sinus-bradycardia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "sinus-bradycardia",
    "id": "HP:0001688",
    "name": "Sinus bradycardia",
    "definition": "Bradycardia related to a mean resting sinus rate of less than 50 beats per minute.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-electrophysiology-of-sinoatrial-node-origin",
        "name": "Abnormal electrophysiology of sinoatrial node origin",
        "url": "https://dantelabs.com/traits/abnormal-electrophysiology-of-sinoatrial-node-origin"
      },
      {
        "slug": "bradycardia",
        "name": "Slow heartbeats",
        "url": "https://dantelabs.com/traits/bradycardia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "calm2",
        "symbol": "CALM2",
        "hgnc": "HGNC:1445",
        "name": "calmodulin 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calm2"
      },
      {
        "slug": "dst",
        "symbol": "DST",
        "hgnc": "HGNC:1090",
        "name": "dystonin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dst"
      },
      {
        "slug": "emd",
        "symbol": "EMD",
        "hgnc": "HGNC:3331",
        "name": "emerin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emd"
      },
      {
        "slug": "fem1b",
        "symbol": "FEM1B",
        "hgnc": "HGNC:3649",
        "name": "fem-1 homolog B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fem1b"
      },
      {
        "slug": "gfm2",
        "symbol": "GFM2",
        "hgnc": "HGNC:29682",
        "name": "GTP dependent ribosome recycling factor mitochondrial 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfm2"
      },
      {
        "slug": "hcn4",
        "symbol": "HCN4",
        "hgnc": "HGNC:16882",
        "name": "hyperpolarization activated cyclic nucleotide gated potassium channel 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hcn4"
      },
      {
        "slug": "hephl1",
        "symbol": "HEPHL1",
        "hgnc": "HGNC:30477",
        "name": "hephaestin like 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hephl1"
      },
      {
        "slug": "kcne1",
        "symbol": "KCNE1",
        "hgnc": "HGNC:6240",
        "name": "potassium voltage-gated channel subfamily E regulatory subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcne1"
      },
      {
        "slug": "tbx5",
        "symbol": "TBX5",
        "hgnc": "HGNC:11604",
        "name": "T-box transcription factor 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx5"
      },
      {
        "slug": "cav3",
        "symbol": "CAV3",
        "hgnc": "HGNC:1529",
        "name": "caveolin 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cav3"
      },
      {
        "slug": "gnb2",
        "symbol": "GNB2",
        "hgnc": "HGNC:4398",
        "name": "G protein subunit beta 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnb2"
      },
      {
        "slug": "myo1h",
        "symbol": "MYO1H",
        "hgnc": "HGNC:13879",
        "name": "myosin IH",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myo1h"
      },
      {
        "slug": "popdc1",
        "symbol": "POPDC1",
        "hgnc": "HGNC:1152",
        "name": "popeye domain cAMP effector 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/popdc1"
      },
      {
        "slug": "popdc2",
        "symbol": "POPDC2",
        "hgnc": "HGNC:17648",
        "name": "popeye domain cAMP effector 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/popdc2"
      },
      {
        "slug": "alpk3",
        "symbol": "ALPK3",
        "hgnc": "HGNC:17574",
        "name": "alpha kinase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alpk3"
      },
      {
        "slug": "cacna1c",
        "symbol": "CACNA1C",
        "hgnc": "HGNC:1390",
        "name": "calcium voltage-gated channel subunit alpha1 C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1c"
      },
      {
        "slug": "kcna5",
        "symbol": "KCNA5",
        "hgnc": "HGNC:6224",
        "name": "potassium voltage-gated channel subfamily A member 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcna5"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "tnnt2",
        "symbol": "TNNT2",
        "hgnc": "HGNC:11949",
        "name": "troponin T2, cardiac type",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnnt2"
      },
      {
        "slug": "ank2",
        "symbol": "ANK2",
        "hgnc": "HGNC:493",
        "name": "ankyrin 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ank2"
      },
      {
        "slug": "prkag2",
        "symbol": "PRKAG2",
        "hgnc": "HGNC:9386",
        "name": "protein kinase AMP-activated non-catalytic subunit gamma 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkag2"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "hgnc": "HGNC:10593",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn5a"
      },
      {
        "slug": "tnni3k",
        "symbol": "TNNI3K",
        "hgnc": "HGNC:19661",
        "name": "TNNI3 interacting kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnni3k"
      }
    ]
  }
}