{
  "url": "https://dantelabs.com/traits/peripheral-cyanosis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "peripheral-cyanosis",
    "id": "HP:0034033",
    "name": "Peripheral cyanosis",
    "definition": "Bluish discoloration of the distal extremities in the absence of cold temperature or stress. Peripheral cyanosis can involve hands, fingertips, or toes, and sometimes circumoral and periorbital areas. Mucous membranes are generally not involved.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "cyanosis",
        "name": "Blue discoloration of the skin",
        "url": "https://dantelabs.com/traits/cyanosis"
      }
    ],
    "narrower": [
      {
        "slug": "acrocyanosis",
        "name": "Persistent blue color of hands or feet",
        "genes": 37,
        "url": "https://dantelabs.com/traits/acrocyanosis"
      },
      {
        "slug": "facial-cyanosis",
        "name": "Bluish face",
        "genes": 0,
        "url": "https://dantelabs.com/traits/facial-cyanosis"
      }
    ],
    "genes": [
      {
        "slug": "cilk1",
        "symbol": "CILK1",
        "hgnc": "HGNC:21219",
        "name": "ciliogenesis associated kinase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cilk1"
      }
    ]
  }
}