{
  "url": "https://dantelabs.com/traits/overgrowth",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "overgrowth",
    "id": "HP:0001548",
    "name": "General overgrowth",
    "label": "Overgrowth",
    "definition": "Excessive postnatal growth which may comprise increased weight, increased length, and/or increased head circumference.",
    "synonyms": [],
    "systems": [
      {
        "slug": "growth-abnormality",
        "name": "Growth abnormality",
        "url": "https://dantelabs.com/traits/growth-abnormality"
      }
    ],
    "broader": [
      {
        "slug": "tall-stature",
        "name": "Tall stature",
        "url": "https://dantelabs.com/traits/tall-stature"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dicer1",
        "symbol": "DICER1",
        "hgnc": "HGNC:17098",
        "name": "dicer 1, ribonuclease III",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dicer1"
      },
      {
        "slug": "dnmt3a",
        "symbol": "DNMT3A",
        "hgnc": "HGNC:2978",
        "name": "DNA methyltransferase 3 alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmt3a"
      },
      {
        "slug": "eed",
        "symbol": "EED",
        "hgnc": "HGNC:3188",
        "name": "embryonic ectoderm development",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eed"
      },
      {
        "slug": "efemp2",
        "symbol": "EFEMP2",
        "hgnc": "HGNC:3219",
        "name": "EGF-like fibulin extracellular matrix protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efemp2"
      },
      {
        "slug": "ezh2",
        "symbol": "EZH2",
        "hgnc": "HGNC:3527",
        "name": "enhancer of zeste 2 polycomb repressive complex 2 subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ezh2"
      },
      {
        "slug": "fibp",
        "symbol": "FIBP",
        "hgnc": "HGNC:3705",
        "name": "FGF1 intracellular binding protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fibp"
      },
      {
        "slug": "gpr101",
        "symbol": "GPR101",
        "hgnc": "HGNC:14963",
        "name": "G protein-coupled receptor 101",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpr101"
      },
      {
        "slug": "kdm2b",
        "symbol": "KDM2B",
        "hgnc": "HGNC:13610",
        "name": "lysine demethylase 2B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm2b"
      },
      {
        "slug": "kdm6b",
        "symbol": "KDM6B",
        "hgnc": "HGNC:29012",
        "name": "lysine demethylase 6B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6b"
      },
      {
        "slug": "nfix",
        "symbol": "NFIX",
        "hgnc": "HGNC:7788",
        "name": "nuclear factor I X",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfix"
      },
      {
        "slug": "pdgfrb",
        "symbol": "PDGFRB",
        "hgnc": "HGNC:8804",
        "name": "platelet derived growth factor receptor beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfrb"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "obligate",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "spin4",
        "symbol": "SPIN4",
        "hgnc": "HGNC:27040",
        "name": "spindlin family member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spin4"
      },
      {
        "slug": "tgfb3",
        "symbol": "TGFB3",
        "hgnc": "HGNC:11769",
        "name": "transforming growth factor beta 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfb3"
      },
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt1"
      },
      {
        "slug": "esr1",
        "symbol": "ESR1",
        "hgnc": "HGNC:3467",
        "name": "estrogen receptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/esr1"
      },
      {
        "slug": "herc1",
        "symbol": "HERC1",
        "hgnc": "HGNC:4867",
        "name": "HECT and RLD domain containing E3 ubiquitin protein ligase family member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/herc1"
      },
      {
        "slug": "rnf135",
        "symbol": "RNF135",
        "hgnc": "HGNC:21158",
        "name": "ring finger protein 135",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf135"
      },
      {
        "slug": "suz12",
        "symbol": "SUZ12",
        "hgnc": "HGNC:17101",
        "name": "SUZ12 polycomb repressive complex 2 subunit",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/suz12"
      },
      {
        "slug": "arhgef9",
        "symbol": "ARHGEF9",
        "hgnc": "HGNC:14561",
        "name": "Cdc42 guanine nucleotide exchange factor 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgef9"
      },
      {
        "slug": "ehmt1",
        "symbol": "EHMT1",
        "hgnc": "HGNC:24650",
        "name": "euchromatic histone lysine methyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ehmt1"
      },
      {
        "slug": "gpc3",
        "symbol": "GPC3",
        "hgnc": "HGNC:4451",
        "name": "glypican 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpc3"
      },
      {
        "slug": "kmt2c",
        "symbol": "KMT2C",
        "hgnc": "HGNC:13726",
        "name": "lysine methyltransferase 2C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2c"
      },
      {
        "slug": "nsd1",
        "symbol": "NSD1",
        "hgnc": "HGNC:14234",
        "name": "nuclear receptor binding SET domain protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsd1"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "camk2a",
        "symbol": "CAMK2A",
        "hgnc": "HGNC:1460",
        "name": "calcium/calmodulin dependent protein kinase II alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/camk2a"
      },
      {
        "slug": "dlk1",
        "symbol": "DLK1",
        "hgnc": "HGNC:2907",
        "name": "delta like non-canonical Notch ligand 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dlk1"
      },
      {
        "slug": "h3-3b",
        "symbol": "H3-3B",
        "hgnc": "HGNC:4765",
        "name": "H3.3 histone B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h3-3b"
      },
      {
        "slug": "hectd4",
        "symbol": "HECTD4",
        "hgnc": "HGNC:26611",
        "name": "HECT domain E3 ubiquitin protein ligase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hectd4"
      },
      {
        "slug": "hnrnpk",
        "symbol": "HNRNPK",
        "hgnc": "HGNC:5044",
        "name": "heterogeneous nuclear ribonucleoprotein K",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hnrnpk"
      },
      {
        "slug": "meg3",
        "symbol": "MEG3",
        "hgnc": "HGNC:14575",
        "name": "maternally expressed 3",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/meg3"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "pik3r2",
        "symbol": "PIK3R2",
        "hgnc": "HGNC:8980",
        "name": "phosphoinositide-3-kinase regulatory subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3r2"
      },
      {
        "slug": "rtl1",
        "symbol": "RTL1",
        "hgnc": "HGNC:14665",
        "name": "retrotransposon Gag like 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rtl1"
      },
      {
        "slug": "cdkn1c",
        "symbol": "CDKN1C",
        "hgnc": "HGNC:1786",
        "name": "cyclin dependent kinase inhibitor 1C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn1c"
      },
      {
        "slug": "fam20a",
        "symbol": "FAM20A",
        "hgnc": "HGNC:23015",
        "name": "FAM20A golgi associated secretory pathway pseudokinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam20a"
      },
      {
        "slug": "fbln5",
        "symbol": "FBLN5",
        "hgnc": "HGNC:3602",
        "name": "fibulin 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbln5"
      },
      {
        "slug": "hras",
        "symbol": "HRAS",
        "hgnc": "HGNC:5173",
        "name": "HRas proto-oncogene, GTPase",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hras"
      },
      {
        "slug": "hspg2",
        "symbol": "HSPG2",
        "hgnc": "HGNC:5273",
        "name": "heparan sulfate proteoglycan 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hspg2"
      },
      {
        "slug": "igf2",
        "symbol": "IGF2",
        "hgnc": "HGNC:5466",
        "name": "insulin like growth factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igf2"
      },
      {
        "slug": "kcnq1",
        "symbol": "KCNQ1",
        "hgnc": "HGNC:6294",
        "name": "potassium voltage-gated channel subfamily Q member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnq1"
      },
      {
        "slug": "kcnq1ot1",
        "symbol": "KCNQ1OT1",
        "hgnc": "HGNC:6295",
        "name": "KCNQ1 opposite strand/antisense transcript 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnq1ot1"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "hgnc": "HGNC:6407",
        "name": "KRas proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kras"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "nras",
        "symbol": "NRAS",
        "hgnc": "HGNC:7989",
        "name": "NRAS proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nras"
      },
      {
        "slug": "setd2",
        "symbol": "SETD2",
        "hgnc": "HGNC:18420",
        "name": "SET domain containing 2, histone lysine methyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setd2"
      },
      {
        "slug": "sost",
        "symbol": "SOST",
        "hgnc": "HGNC:13771",
        "name": "sclerostin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sost"
      }
    ]
  }
}