{
  "url": "https://dantelabs.com/traits/osteochondrosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "osteochondrosis",
    "id": "HP:0040188",
    "name": "Osteochondrosis",
    "definition": "Abnormal growth ossification centers in children. Initially a degeneration/ necrosis followed by regeneration or recalcification.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-joint-morphology",
        "name": "Abnormal shape of joints",
        "url": "https://dantelabs.com/traits/abnormal-joint-morphology"
      },
      {
        "slug": "juvenile-aseptic-necrosis",
        "name": "Juvenile aseptic necrosis",
        "url": "https://dantelabs.com/traits/juvenile-aseptic-necrosis"
      }
    ],
    "narrower": [
      {
        "slug": "osteochondritis-dissecans",
        "name": "Osteochondritis dissecans",
        "genes": 6,
        "url": "https://dantelabs.com/traits/osteochondritis-dissecans"
      }
    ],
    "genes": [
      {
        "slug": "actb",
        "symbol": "ACTB",
        "hgnc": "HGNC:132",
        "name": "actin beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actb"
      },
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "hgnc": "HGNC:144",
        "name": "actin gamma 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actg1"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "hgnc": "HGNC:6407",
        "name": "KRas proto-oncogene, GTPase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kras"
      },
      {
        "slug": "dyrk1a",
        "symbol": "DYRK1A",
        "hgnc": "HGNC:3091",
        "name": "dual specificity tyrosine phosphorylation regulated kinase 1A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dyrk1a"
      }
    ]
  }
}