{
  "url": "https://dantelabs.com/traits/organic-aciduria",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "organic-aciduria",
    "id": "HP:0001992",
    "name": "Organic aciduria",
    "definition": "Excretion of non-amino organic acids in urine.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "aciduria",
        "name": "Acidic urine",
        "url": "https://dantelabs.com/traits/aciduria"
      }
    ],
    "narrower": [
      {
        "slug": "hyperoxaluria",
        "name": "High urine oxalate levels",
        "genes": 6,
        "url": "https://dantelabs.com/traits/hyperoxaluria"
      },
      {
        "slug": "3-hydroxyisovaleric-aciduria",
        "name": "3-hydroxyisovaleric aciduria",
        "genes": 4,
        "url": "https://dantelabs.com/traits/3-hydroxyisovaleric-aciduria"
      },
      {
        "slug": "complex-organic-aciduria",
        "name": "Complex organic aciduria",
        "genes": 1,
        "url": "https://dantelabs.com/traits/complex-organic-aciduria"
      },
      {
        "slug": "increased-urine-4-hydroxy-2-oxoglutarate-level",
        "name": "Increased urine 4-hydroxy-2-oxoglutarate level",
        "genes": 1,
        "url": "https://dantelabs.com/traits/increased-urine-4-hydroxy-2-oxoglutarate-level"
      },
      {
        "slug": "elevated-urinary-carboxylic-acid",
        "name": "Elevated urinary carboxylic acid",
        "genes": 0,
        "url": "https://dantelabs.com/traits/elevated-urinary-carboxylic-acid"
      }
    ],
    "genes": [
      {
        "slug": "abcb7",
        "symbol": "ABCB7",
        "hgnc": "HGNC:48",
        "name": "ATP binding cassette subfamily B member 7",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abcb7"
      },
      {
        "slug": "btd",
        "symbol": "BTD",
        "hgnc": "HGNC:1122",
        "name": "biotinidase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/btd"
      },
      {
        "slug": "mccc1",
        "symbol": "MCCC1",
        "hgnc": "HGNC:6936",
        "name": "methylcrotonyl-CoA carboxylase subunit 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mccc1"
      },
      {
        "slug": "mccc2",
        "symbol": "MCCC2",
        "hgnc": "HGNC:6937",
        "name": "methylcrotonyl-CoA carboxylase subunit 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mccc2"
      },
      {
        "slug": "pcca",
        "symbol": "PCCA",
        "hgnc": "HGNC:8653",
        "name": "propionyl-CoA carboxylase subunit alpha",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcca"
      },
      {
        "slug": "pccb",
        "symbol": "PCCB",
        "hgnc": "HGNC:8654",
        "name": "propionyl-CoA carboxylase subunit beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pccb"
      },
      {
        "slug": "slc25a19",
        "symbol": "SLC25A19",
        "hgnc": "HGNC:14409",
        "name": "solute carrier family 25 member 19",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a19"
      },
      {
        "slug": "hlcs",
        "symbol": "HLCS",
        "hgnc": "HGNC:4976",
        "name": "holocarboxylase synthetase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hlcs"
      },
      {
        "slug": "nadk2",
        "symbol": "NADK2",
        "hgnc": "HGNC:26404",
        "name": "NAD kinase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nadk2"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "polrmt",
        "symbol": "POLRMT",
        "hgnc": "HGNC:9200",
        "name": "RNA polymerase mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polrmt"
      },
      {
        "slug": "slc52a2",
        "symbol": "SLC52A2",
        "hgnc": "HGNC:30224",
        "name": "solute carrier family 52 member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc52a2"
      },
      {
        "slug": "flad1",
        "symbol": "FLAD1",
        "hgnc": "HGNC:24671",
        "name": "flavin adenine dinucleotide synthetase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flad1"
      },
      {
        "slug": "gatm",
        "symbol": "GATM",
        "hgnc": "HGNC:4175",
        "name": "glycine amidinotransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gatm"
      },
      {
        "slug": "hmgcl",
        "symbol": "HMGCL",
        "hgnc": "HGNC:5005",
        "name": "3-hydroxy-3-methylglutaryl-CoA lyase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmgcl"
      },
      {
        "slug": "mpc1",
        "symbol": "MPC1",
        "hgnc": "HGNC:21606",
        "name": "mitochondrial pyruvate carrier 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpc1"
      }
    ]
  }
}