{
  "url": "https://dantelabs.com/traits/lower-lip-pit",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "lower-lip-pit",
    "id": "HP:0000196",
    "name": "Lower lip pit",
    "definition": "Depression located on the vermilion of the lower lip, usually paramedian.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-lower-lip-morphology",
        "name": "Abnormality of lower lip",
        "url": "https://dantelabs.com/traits/abnormal-lower-lip-morphology"
      },
      {
        "slug": "paramedian-lip-pit",
        "name": "Paramedian lip pit",
        "url": "https://dantelabs.com/traits/paramedian-lip-pit"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "irf6",
        "symbol": "IRF6",
        "hgnc": "HGNC:6121",
        "name": "interferon regulatory factor 6",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/irf6"
      },
      {
        "slug": "grhl3",
        "symbol": "GRHL3",
        "hgnc": "HGNC:25839",
        "name": "grainyhead like transcription factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grhl3"
      },
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "tfap2a",
        "symbol": "TFAP2A",
        "hgnc": "HGNC:11742",
        "name": "transcription factor AP-2 alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfap2a"
      }
    ]
  }
}