{
  "url": "https://dantelabs.com/traits/large-intestinal-polyposis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "large-intestinal-polyposis",
    "id": "HP:0030255",
    "name": "Large intestinal polyposis",
    "definition": "The presence of multiple polyps in the large intestine.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "intestinal-polyposis",
        "name": "Growths in inner lining of intestine",
        "url": "https://dantelabs.com/traits/intestinal-polyposis"
      }
    ],
    "narrower": [
      {
        "slug": "adenomatous-colonic-polyposis",
        "name": "Adenomatous colonic polyposis",
        "genes": 17,
        "url": "https://dantelabs.com/traits/adenomatous-colonic-polyposis"
      },
      {
        "slug": "colorectal-polyposis",
        "name": "Colorectal polyposis",
        "genes": 17,
        "url": "https://dantelabs.com/traits/colorectal-polyposis"
      },
      {
        "slug": "rectal-polyposis",
        "name": "Rectal polyposis",
        "genes": 6,
        "url": "https://dantelabs.com/traits/rectal-polyposis"
      },
      {
        "slug": "juvenile-colonic-polyposis",
        "name": "Juvenile colonic polyposis",
        "genes": 3,
        "url": "https://dantelabs.com/traits/juvenile-colonic-polyposis"
      },
      {
        "slug": "hyperplastic-colonic-polyposis",
        "name": "Hyperplastic colonic polyposis",
        "genes": 2,
        "url": "https://dantelabs.com/traits/hyperplastic-colonic-polyposis"
      }
    ],
    "genes": [
      {
        "slug": "apc",
        "symbol": "APC",
        "hgnc": "HGNC:583",
        "name": "APC regulator of Wnt signaling pathway",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc"
      },
      {
        "slug": "mutyh",
        "symbol": "MUTYH",
        "hgnc": "HGNC:7527",
        "name": "mutY DNA glycosylase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mutyh"
      },
      {
        "slug": "flcn",
        "symbol": "FLCN",
        "hgnc": "HGNC:27310",
        "name": "folliculin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flcn"
      }
    ]
  }
}