{
  "url": "https://dantelabs.com/traits/joint-hemorrhage",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "joint-hemorrhage",
    "id": "HP:0005261",
    "name": "Bleeding within a joint",
    "label": "Joint hemorrhage",
    "definition": "Hemorrhage occurring within a joint.",
    "synonyms": [
      "Hemarthrosis",
      "Hemarthroses",
      "Spontaneous joint haemorrhage",
      "Spontaneous joint hemorrhage"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-joint-morphology",
        "name": "Abnormal shape of joints",
        "url": "https://dantelabs.com/traits/abnormal-joint-morphology"
      },
      {
        "slug": "internal-hemorrhage",
        "name": "Internal bleeding",
        "url": "https://dantelabs.com/traits/internal-hemorrhage"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "f7",
        "symbol": "F7",
        "hgnc": "HGNC:3544",
        "name": "coagulation factor VII",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f7"
      },
      {
        "slug": "f9",
        "symbol": "F9",
        "hgnc": "HGNC:3551",
        "name": "coagulation factor IX",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f9"
      },
      {
        "slug": "serpinf2",
        "symbol": "SERPINF2",
        "hgnc": "HGNC:9075",
        "name": "serpin family F member 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/serpinf2"
      },
      {
        "slug": "f13a1",
        "symbol": "F13A1",
        "hgnc": "HGNC:3531",
        "name": "coagulation factor XIII A chain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f13a1"
      },
      {
        "slug": "f13b",
        "symbol": "F13B",
        "hgnc": "HGNC:3534",
        "name": "coagulation factor XIII B chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f13b"
      },
      {
        "slug": "f2",
        "symbol": "F2",
        "hgnc": "HGNC:3535",
        "name": "coagulation factor II, thrombin",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f2"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "hgnc": "HGNC:3542",
        "name": "coagulation factor V",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f5"
      },
      {
        "slug": "f8",
        "symbol": "F8",
        "hgnc": "HGNC:3546",
        "name": "coagulation factor VIII",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/f8"
      },
      {
        "slug": "f10",
        "symbol": "F10",
        "hgnc": "HGNC:3528",
        "name": "coagulation factor X",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f10"
      },
      {
        "slug": "ggcx",
        "symbol": "GGCX",
        "hgnc": "HGNC:4247",
        "name": "gamma-glutamyl carboxylase",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ggcx"
      },
      {
        "slug": "lman1",
        "symbol": "LMAN1",
        "hgnc": "HGNC:6631",
        "name": "lectin, mannose binding 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lman1"
      },
      {
        "slug": "mcfd2",
        "symbol": "MCFD2",
        "hgnc": "HGNC:18451",
        "name": "multiple coagulation factor deficiency 2, ER cargo receptor complex subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcfd2"
      },
      {
        "slug": "vkorc1",
        "symbol": "VKORC1",
        "hgnc": "HGNC:23663",
        "name": "vitamin K epoxide reductase complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vkorc1"
      },
      {
        "slug": "vwf",
        "symbol": "VWF",
        "hgnc": "HGNC:12726",
        "name": "von Willebrand factor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vwf"
      },
      {
        "slug": "f11",
        "symbol": "F11",
        "hgnc": "HGNC:3529",
        "name": "coagulation factor XI",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f11"
      },
      {
        "slug": "serpine1",
        "symbol": "SERPINE1",
        "hgnc": "HGNC:8583",
        "name": "serpin family E member 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpine1"
      },
      {
        "slug": "plau",
        "symbol": "PLAU",
        "hgnc": "HGNC:9052",
        "name": "plasminogen activator, urokinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plau"
      },
      {
        "slug": "was",
        "symbol": "WAS",
        "hgnc": "HGNC:12731",
        "name": "WASP actin nucleation promoting factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/was"
      }
    ]
  }
}