{
  "url": "https://dantelabs.com/traits/increased-plasmablast-proportion",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-plasmablast-proportion",
    "id": "HP:0032128",
    "name": "Increased plasmablast proportion",
    "definition": "Abnormal increase of plasmablasts, commonly characterized as CD27+CD38hi and sometimes additionally as IgMlowCD24-, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-plasmablast-proportion",
        "name": "Abnormal plasmablast proportion",
        "url": "https://dantelabs.com/traits/abnormal-plasmablast-proportion"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "man2b2",
        "symbol": "MAN2B2",
        "hgnc": "HGNC:29623",
        "name": "mannosidase alpha class 2B member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/man2b2"
      },
      {
        "slug": "sec61a1",
        "symbol": "SEC61A1",
        "hgnc": "HGNC:18276",
        "name": "SEC61 translocon subunit alpha 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec61a1"
      }
    ]
  }
}