{
  "url": "https://dantelabs.com/traits/increased-memory-cd8-t-cell-proportion",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-memory-cd8-t-cell-proportion",
    "id": "HP:0410392",
    "name": "Increased memory CD8+ T cell proportion",
    "definition": "Abnormal increase of the memory CD8+ T cell subpopulation, commonly characterized as CD45RA-, CD45RO+, or CD27-, measured as percentage of total CD8+ T cells in the blood, compared to a reference range for a given sex and age-group.",
    "synonyms": [
      "Increased proportion of CD8-positive memory T cells"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-memory-cd8-t-cell-proportion",
        "name": "Abnormal memory CD8+ T cell proportion",
        "url": "https://dantelabs.com/traits/abnormal-memory-cd8-t-cell-proportion"
      },
      {
        "slug": "increased-memory-t-cell-proportion",
        "name": "Increased memory T cell proportion",
        "url": "https://dantelabs.com/traits/increased-memory-t-cell-proportion"
      }
    ],
    "narrower": [
      {
        "slug": "increased-cd8-temra-t-cell-proportion",
        "name": "Increased CD8+ TEMRA T cell proportion",
        "genes": 2,
        "url": "https://dantelabs.com/traits/increased-cd8-temra-t-cell-proportion"
      },
      {
        "slug": "increased-effector-memory-cd8-t-cell-proportion",
        "name": "Increased effector memory CD8+ T cell proportion",
        "genes": 2,
        "url": "https://dantelabs.com/traits/increased-effector-memory-cd8-t-cell-proportion"
      },
      {
        "slug": "increased-central-memory-cd8-t-cell-proportion",
        "name": "Increased central memory CD8+ T cell proportion",
        "genes": 1,
        "url": "https://dantelabs.com/traits/increased-central-memory-cd8-t-cell-proportion"
      }
    ],
    "genes": [
      {
        "slug": "irf4",
        "symbol": "IRF4",
        "hgnc": "HGNC:6119",
        "name": "interferon regulatory factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf4"
      }
    ]
  }
}