{
  "url": "https://dantelabs.com/traits/hypotelorism",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypotelorism",
    "id": "HP:0000601",
    "name": "Abnormally close eyes",
    "label": "Hypotelorism",
    "definition": "Interpupillary distance less than 2 SD below the mean (alternatively, the appearance of an decreased interpupillary distance or closely spaced eyes).",
    "synonyms": [
      "Closely spaced eyes",
      "Decreased distance between eye sockets",
      "Decreased distance between eyes",
      "Decreased interpupillary distance",
      "Decreased orbital separation",
      "Ocular hypotelorism"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-globe-location",
        "name": "Abnormality of eyeball location",
        "url": "https://dantelabs.com/traits/abnormality-of-globe-location"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "acbd5",
        "symbol": "ACBD5",
        "hgnc": "HGNC:23338",
        "name": "acyl-CoA binding domain containing 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acbd5"
      },
      {
        "slug": "ap3d1",
        "symbol": "AP3D1",
        "hgnc": "HGNC:568",
        "name": "adaptor related protein complex 3 subunit delta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap3d1"
      },
      {
        "slug": "atp6ap1",
        "symbol": "ATP6AP1",
        "hgnc": "HGNC:868",
        "name": "ATPase H+ transporting accessory protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6ap1"
      },
      {
        "slug": "cep57",
        "symbol": "CEP57",
        "hgnc": "HGNC:30794",
        "name": "centrosomal protein 57",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep57"
      },
      {
        "slug": "cilk1",
        "symbol": "CILK1",
        "hgnc": "HGNC:21219",
        "name": "ciliogenesis associated kinase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cilk1"
      },
      {
        "slug": "cox14",
        "symbol": "COX14",
        "hgnc": "HGNC:28216",
        "name": "cytochrome c oxidase assembly factor COX14",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox14"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "obligate",
        "diseases": 6,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "fkbp14",
        "symbol": "FKBP14",
        "hgnc": "HGNC:18625",
        "name": "FKBP prolyl isomerase 14",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fkbp14"
      },
      {
        "slug": "gtf2h5",
        "symbol": "GTF2H5",
        "hgnc": "HGNC:21157",
        "name": "general transcription factor IIH subunit 5",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gtf2h5"
      },
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "kdm6b",
        "symbol": "KDM6B",
        "hgnc": "HGNC:29012",
        "name": "lysine demethylase 6B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6b"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "nin",
        "symbol": "NIN",
        "hgnc": "HGNC:14906",
        "name": "ninein",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nin"
      },
      {
        "slug": "pan2",
        "symbol": "PAN2",
        "hgnc": "HGNC:20074",
        "name": "poly(A) specific ribonuclease subunit PAN2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pan2"
      },
      {
        "slug": "prps1",
        "symbol": "PRPS1",
        "hgnc": "HGNC:9462",
        "name": "phosphoribosyl pyrophosphate synthetase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prps1"
      },
      {
        "slug": "rnu2-2",
        "symbol": "RNU2-2",
        "hgnc": "HGNC:10152",
        "name": "RNA, U2 small nuclear 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu2-2"
      },
      {
        "slug": "six3",
        "symbol": "SIX3",
        "hgnc": "HGNC:10889",
        "name": "SIX homeobox 3",
        "frequency": "obligate",
        "diseases": 6,
        "url": "https://dantelabs.com/genes/six3"
      },
      {
        "slug": "ubr5",
        "symbol": "UBR5",
        "hgnc": "HGNC:16806",
        "name": "ubiquitin protein ligase E3 component n-recognin 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubr5"
      },
      {
        "slug": "xrcc4",
        "symbol": "XRCC4",
        "hgnc": "HGNC:12831",
        "name": "X-ray repair cross complementing 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xrcc4"
      },
      {
        "slug": "cdon",
        "symbol": "CDON",
        "hgnc": "HGNC:17104",
        "name": "cell adhesion associated, oncogene regulated",
        "frequency": "very-frequent",
        "diseases": 6,
        "url": "https://dantelabs.com/genes/cdon"
      },
      {
        "slug": "cripto",
        "symbol": "CRIPTO",
        "hgnc": "HGNC:11701",
        "name": "cripto, EGF-CFC family member",
        "frequency": "very-frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/cripto"
      },
      {
        "slug": "disp1",
        "symbol": "DISP1",
        "hgnc": "HGNC:19711",
        "name": "dispatched RND transporter family member 1",
        "frequency": "very-frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/disp1"
      },
      {
        "slug": "dll1",
        "symbol": "DLL1",
        "hgnc": "HGNC:2908",
        "name": "delta like canonical Notch ligand 1",
        "frequency": "very-frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/dll1"
      },
      {
        "slug": "fgf8",
        "symbol": "FGF8",
        "hgnc": "HGNC:3686",
        "name": "fibroblast growth factor 8",
        "frequency": "very-frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/fgf8"
      },
      {
        "slug": "foxh1",
        "symbol": "FOXH1",
        "hgnc": "HGNC:3814",
        "name": "forkhead box H1",
        "frequency": "very-frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/foxh1"
      },
      {
        "slug": "gas1",
        "symbol": "GAS1",
        "hgnc": "HGNC:4165",
        "name": "growth arrest specific 1",
        "frequency": "very-frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/gas1"
      },
      {
        "slug": "gli2",
        "symbol": "GLI2",
        "hgnc": "HGNC:4318",
        "name": "GLI family zinc finger 2",
        "frequency": "very-frequent",
        "diseases": 7,
        "url": "https://dantelabs.com/genes/gli2"
      },
      {
        "slug": "ndp",
        "symbol": "NDP",
        "hgnc": "HGNC:7678",
        "name": "norrin cystine knot growth factor NDP",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndp"
      },
      {
        "slug": "nodal",
        "symbol": "NODAL",
        "hgnc": "HGNC:7865",
        "name": "nodal growth differentiation factor",
        "frequency": "very-frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/nodal"
      },
      {
        "slug": "plch1",
        "symbol": "PLCH1",
        "hgnc": "HGNC:29185",
        "name": "phospholipase C eta 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plch1"
      },
      {
        "slug": "ptch1",
        "symbol": "PTCH1",
        "hgnc": "HGNC:9585",
        "name": "patched 1",
        "frequency": "very-frequent",
        "diseases": 6,
        "url": "https://dantelabs.com/genes/ptch1"
      },
      {
        "slug": "shh",
        "symbol": "SHH",
        "hgnc": "HGNC:10848",
        "name": "sonic hedgehog signaling molecule",
        "frequency": "very-frequent",
        "diseases": 7,
        "url": "https://dantelabs.com/genes/shh"
      },
      {
        "slug": "smc1a",
        "symbol": "SMC1A",
        "hgnc": "HGNC:11111",
        "name": "structural maintenance of chromosomes 1A",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smc1a"
      },
      {
        "slug": "stag2",
        "symbol": "STAG2",
        "hgnc": "HGNC:11355",
        "name": "STAG2 cohesin complex component",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/stag2"
      },
      {
        "slug": "stil",
        "symbol": "STIL",
        "hgnc": "HGNC:10879",
        "name": "STIL centriolar assembly protein",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/stil"
      },
      {
        "slug": "tgif1",
        "symbol": "TGIF1",
        "hgnc": "HGNC:11776",
        "name": "TGFB induced factor homeobox 1",
        "frequency": "very-frequent",
        "diseases": 6,
        "url": "https://dantelabs.com/genes/tgif1"
      },
      {
        "slug": "zic2",
        "symbol": "ZIC2",
        "hgnc": "HGNC:12873",
        "name": "Zic family zinc finger 2",
        "frequency": "very-frequent",
        "diseases": 6,
        "url": "https://dantelabs.com/genes/zic2"
      },
      {
        "slug": "aars1",
        "symbol": "AARS1",
        "hgnc": "HGNC:20",
        "name": "alanyl-tRNA synthetase 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/aars1"
      },
      {
        "slug": "abcc9",
        "symbol": "ABCC9",
        "hgnc": "HGNC:60",
        "name": "ATP binding cassette subfamily C member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc9"
      },
      {
        "slug": "arcn1",
        "symbol": "ARCN1",
        "hgnc": "HGNC:649",
        "name": "archain 1 coat protein complex I subunit delta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arcn1"
      },
      {
        "slug": "ccdc32",
        "symbol": "CCDC32",
        "hgnc": "HGNC:28295",
        "name": "coiled-coil domain containing 32",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc32"
      },
      {
        "slug": "cdk19",
        "symbol": "CDK19",
        "hgnc": "HGNC:19338",
        "name": "cyclin dependent kinase 19",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdk19"
      },
      {
        "slug": "dclre1b",
        "symbol": "DCLRE1B",
        "hgnc": "HGNC:17641",
        "name": "DNA cross-link repair 1B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dclre1b"
      },
      {
        "slug": "dpysl5",
        "symbol": "DPYSL5",
        "hgnc": "HGNC:20637",
        "name": "dihydropyrimidinase like 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpysl5"
      },
      {
        "slug": "dyrk1a",
        "symbol": "DYRK1A",
        "hgnc": "HGNC:3091",
        "name": "dual specificity tyrosine phosphorylation regulated kinase 1A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dyrk1a"
      },
      {
        "slug": "farsb",
        "symbol": "FARSB",
        "hgnc": "HGNC:17800",
        "name": "phenylalanyl-tRNA synthetase subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/farsb"
      },
      {
        "slug": "frem1",
        "symbol": "FREM1",
        "hgnc": "HGNC:23399",
        "name": "FRAS1 related extracellular matrix 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/frem1"
      },
      {
        "slug": "ggt1",
        "symbol": "GGT1",
        "hgnc": "HGNC:4250",
        "name": "gamma-glutamyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ggt1"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "gpt2",
        "symbol": "GPT2",
        "hgnc": "HGNC:18062",
        "name": "glutamic--pyruvic transaminase 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gpt2"
      },
      {
        "slug": "ift122",
        "symbol": "IFT122",
        "hgnc": "HGNC:13556",
        "name": "intraflagellar transport 122",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ift122"
      },
      {
        "slug": "ift43",
        "symbol": "IFT43",
        "hgnc": "HGNC:29669",
        "name": "intraflagellar transport 43",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift43"
      },
      {
        "slug": "ift52",
        "symbol": "IFT52",
        "hgnc": "HGNC:15901",
        "name": "intraflagellar transport 52",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift52"
      },
      {
        "slug": "lrrc8c",
        "symbol": "LRRC8C",
        "hgnc": "HGNC:25075",
        "name": "leucine rich repeat containing 8 VRAC subunit C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc8c"
      },
      {
        "slug": "msto1",
        "symbol": "MSTO1",
        "hgnc": "HGNC:29678",
        "name": "misato mitochondrial distribution and morphology regulator 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msto1"
      },
      {
        "slug": "nde1",
        "symbol": "NDE1",
        "hgnc": "HGNC:17619",
        "name": "nudE neurodevelopment protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nde1"
      },
      {
        "slug": "pdgfrb",
        "symbol": "PDGFRB",
        "hgnc": "HGNC:8804",
        "name": "platelet derived growth factor receptor beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfrb"
      },
      {
        "slug": "pi4k2a",
        "symbol": "PI4K2A",
        "hgnc": "HGNC:30031",
        "name": "phosphatidylinositol 4-kinase type 2 alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pi4k2a"
      },
      {
        "slug": "polr3a",
        "symbol": "POLR3A",
        "hgnc": "HGNC:30074",
        "name": "RNA polymerase III subunit A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3a"
      },
      {
        "slug": "qars1",
        "symbol": "QARS1",
        "hgnc": "HGNC:9751",
        "name": "glutaminyl-tRNA synthetase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/qars1"
      },
      {
        "slug": "rab3gap1",
        "symbol": "RAB3GAP1",
        "hgnc": "HGNC:17063",
        "name": "RAB3 GTPase activating protein catalytic subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab3gap1"
      },
      {
        "slug": "rab3gap2",
        "symbol": "RAB3GAP2",
        "hgnc": "HGNC:17168",
        "name": "RAB3 GTPase activating non-catalytic protein subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab3gap2"
      },
      {
        "slug": "rad21",
        "symbol": "RAD21",
        "hgnc": "HGNC:9811",
        "name": "RAD21 cohesin complex component",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad21"
      },
      {
        "slug": "shpk",
        "symbol": "SHPK",
        "hgnc": "HGNC:1492",
        "name": "sedoheptulokinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/shpk"
      },
      {
        "slug": "slc4a10",
        "symbol": "SLC4A10",
        "hgnc": "HGNC:13811",
        "name": "solute carrier family 4 member 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc4a10"
      },
      {
        "slug": "sufu",
        "symbol": "SUFU",
        "hgnc": "HGNC:16466",
        "name": "SUFU negative regulator of hedgehog signaling",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sufu"
      },
      {
        "slug": "trappc9",
        "symbol": "TRAPPC9",
        "hgnc": "HGNC:30832",
        "name": "trafficking protein particle complex subunit 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc9"
      },
      {
        "slug": "wdr19",
        "symbol": "WDR19",
        "hgnc": "HGNC:18340",
        "name": "WD repeat domain 19",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr19"
      },
      {
        "slug": "wdr35",
        "symbol": "WDR35",
        "hgnc": "HGNC:29250",
        "name": "WD repeat domain 35",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr35"
      },
      {
        "slug": "wdr83os",
        "symbol": "WDR83OS",
        "hgnc": "HGNC:30203",
        "name": "WD repeat domain 83 opposite strand",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr83os"
      },
      {
        "slug": "aass",
        "symbol": "AASS",
        "hgnc": "HGNC:17366",
        "name": "aminoadipate-semialdehyde synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aass"
      },
      {
        "slug": "bicra",
        "symbol": "BICRA",
        "hgnc": "HGNC:4332",
        "name": "BRD4 interacting chromatin remodeling complex associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bicra"
      },
      {
        "slug": "camk2a",
        "symbol": "CAMK2A",
        "hgnc": "HGNC:1460",
        "name": "calcium/calmodulin dependent protein kinase II alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/camk2a"
      },
      {
        "slug": "caprin1",
        "symbol": "CAPRIN1",
        "hgnc": "HGNC:6743",
        "name": "cell cycle associated protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/caprin1"
      },
      {
        "slug": "cars1",
        "symbol": "CARS1",
        "hgnc": "HGNC:1493",
        "name": "cysteinyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cars1"
      },
      {
        "slug": "clcn3",
        "symbol": "CLCN3",
        "hgnc": "HGNC:2021",
        "name": "Cl-/H+ antiporter 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcn3"
      },
      {
        "slug": "cnot1",
        "symbol": "CNOT1",
        "hgnc": "HGNC:7877",
        "name": "CCR4-NOT transcription complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cnot1"
      },
      {
        "slug": "cnot3",
        "symbol": "CNOT3",
        "hgnc": "HGNC:7879",
        "name": "CCR4-NOT transcription complex subunit 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cnot3"
      },
      {
        "slug": "cux1",
        "symbol": "CUX1",
        "hgnc": "HGNC:2557",
        "name": "cut like homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cux1"
      },
      {
        "slug": "dbr1",
        "symbol": "DBR1",
        "hgnc": "HGNC:15594",
        "name": "debranching RNA lariats 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dbr1"
      },
      {
        "slug": "ddb1",
        "symbol": "DDB1",
        "hgnc": "HGNC:2717",
        "name": "damage specific DNA binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddb1"
      },
      {
        "slug": "dpm2",
        "symbol": "DPM2",
        "hgnc": "HGNC:3006",
        "name": "dolichyl-phosphate mannosyltransferase subunit 2, regulatory",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dpm2"
      },
      {
        "slug": "eln",
        "symbol": "ELN",
        "hgnc": "HGNC:3327",
        "name": "elastin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eln"
      },
      {
        "slug": "epg5",
        "symbol": "EPG5",
        "hgnc": "HGNC:29331",
        "name": "ectopic P-granules 5 autophagy tethering factor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/epg5"
      },
      {
        "slug": "ercc2",
        "symbol": "ERCC2",
        "hgnc": "HGNC:3434",
        "name": "ERCC excision repair 2, TFIIH core complex helicase subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc2"
      },
      {
        "slug": "ercc3",
        "symbol": "ERCC3",
        "hgnc": "HGNC:3435",
        "name": "ERCC excision repair 3, TFIIH core complex helicase subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc3"
      },
      {
        "slug": "fancd2",
        "symbol": "FANCD2",
        "hgnc": "HGNC:3585",
        "name": "FA complementation group D2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancd2"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr2"
      },
      {
        "slug": "fgfr3",
        "symbol": "FGFR3",
        "hgnc": "HGNC:3690",
        "name": "fibroblast growth factor receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr3"
      },
      {
        "slug": "gata2",
        "symbol": "GATA2",
        "hgnc": "HGNC:4171",
        "name": "GATA binding protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata2"
      },
      {
        "slug": "gnb2",
        "symbol": "GNB2",
        "hgnc": "HGNC:4398",
        "name": "G protein subunit beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnb2"
      },
      {
        "slug": "gon7",
        "symbol": "GON7",
        "hgnc": "HGNC:20356",
        "name": "GON7 subunit of KEOPS complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gon7"
      },
      {
        "slug": "gtf2e2",
        "symbol": "GTF2E2",
        "hgnc": "HGNC:4651",
        "name": "general transcription factor IIE subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtf2e2"
      },
      {
        "slug": "hnrnpc",
        "symbol": "HNRNPC",
        "hgnc": "HGNC:5035",
        "name": "heterogeneous nuclear ribonucleoprotein C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnrnpc"
      },
      {
        "slug": "hnrnph2",
        "symbol": "HNRNPH2",
        "hgnc": "HGNC:5042",
        "name": "heterogeneous nuclear ribonucleoprotein H2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnrnph2"
      },
      {
        "slug": "huwe1",
        "symbol": "HUWE1",
        "hgnc": "HGNC:30892",
        "name": "HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/huwe1"
      },
      {
        "slug": "kansl1",
        "symbol": "KANSL1",
        "hgnc": "HGNC:24565",
        "name": "KAT8 regulatory NSL complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kansl1"
      },
      {
        "slug": "kat8",
        "symbol": "KAT8",
        "hgnc": "HGNC:17933",
        "name": "lysine acetyltransferase 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kat8"
      },
      {
        "slug": "kctd1",
        "symbol": "KCTD1",
        "hgnc": "HGNC:18249",
        "name": "potassium channel tetramerization domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kctd1"
      },
      {
        "slug": "kdm2b",
        "symbol": "KDM2B",
        "hgnc": "HGNC:13610",
        "name": "lysine demethylase 2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm2b"
      },
      {
        "slug": "kif26a",
        "symbol": "KIF26A",
        "hgnc": "HGNC:20226",
        "name": "kinesin family member 26A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif26a"
      },
      {
        "slug": "lage3",
        "symbol": "LAGE3",
        "hgnc": "HGNC:26058",
        "name": "L antigen family member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lage3"
      },
      {
        "slug": "med16",
        "symbol": "MED16",
        "hgnc": "HGNC:17556",
        "name": "mediator complex subunit 16",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med16"
      },
      {
        "slug": "mlxipl",
        "symbol": "MLXIPL",
        "hgnc": "HGNC:12744",
        "name": "MLX interacting protein like",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mlxipl"
      },
      {
        "slug": "mplkip",
        "symbol": "MPLKIP",
        "hgnc": "HGNC:16002",
        "name": "M-phase specific PLK1 interacting protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mplkip"
      },
      {
        "slug": "msl2",
        "symbol": "MSL2",
        "hgnc": "HGNC:25544",
        "name": "MSL complex subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msl2"
      },
      {
        "slug": "msx2",
        "symbol": "MSX2",
        "hgnc": "HGNC:7392",
        "name": "msh homeobox 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msx2"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "ntng2",
        "symbol": "NTNG2",
        "hgnc": "HGNC:14288",
        "name": "netrin G2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ntng2"
      },
      {
        "slug": "nup107",
        "symbol": "NUP107",
        "hgnc": "HGNC:29914",
        "name": "nucleoporin 107",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup107"
      },
      {
        "slug": "nup133",
        "symbol": "NUP133",
        "hgnc": "HGNC:18016",
        "name": "nucleoporin 133",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup133"
      },
      {
        "slug": "osgep",
        "symbol": "OSGEP",
        "hgnc": "HGNC:18028",
        "name": "O-sialoglycoprotein endopeptidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/osgep"
      },
      {
        "slug": "pde4d",
        "symbol": "PDE4D",
        "hgnc": "HGNC:8783",
        "name": "phosphodiesterase 4D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde4d"
      },
      {
        "slug": "polrmt",
        "symbol": "POLRMT",
        "hgnc": "HGNC:9200",
        "name": "RNA polymerase mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polrmt"
      },
      {
        "slug": "ppp1r15b",
        "symbol": "PPP1R15B",
        "hgnc": "HGNC:14951",
        "name": "protein phosphatase 1 regulatory subunit 15B",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ppp1r15b"
      },
      {
        "slug": "prkar1b",
        "symbol": "PRKAR1B",
        "hgnc": "HGNC:9390",
        "name": "protein kinase cAMP-dependent type I regulatory subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1b"
      },
      {
        "slug": "pycr1",
        "symbol": "PYCR1",
        "hgnc": "HGNC:9721",
        "name": "pyrroline-5-carboxylate reductase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pycr1"
      },
      {
        "slug": "recql4",
        "symbol": "RECQL4",
        "hgnc": "HGNC:9949",
        "name": "RecQ like helicase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/recql4"
      },
      {
        "slug": "rere",
        "symbol": "RERE",
        "hgnc": "HGNC:9965",
        "name": "arginine-glutamic acid dipeptide repeats",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rere"
      },
      {
        "slug": "rnf113a",
        "symbol": "RNF113A",
        "hgnc": "HGNC:12974",
        "name": "ring finger protein 113A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf113a"
      },
      {
        "slug": "rnu4-2",
        "symbol": "RNU4-2",
        "hgnc": "HGNC:10193",
        "name": "RNA, U4 small nuclear 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu4-2"
      },
      {
        "slug": "rttn",
        "symbol": "RTTN",
        "hgnc": "HGNC:18654",
        "name": "rotatin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rttn"
      },
      {
        "slug": "snrpn",
        "symbol": "SNRPN",
        "hgnc": "HGNC:11164",
        "name": "small nuclear ribonucleoprotein polypeptide N",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snrpn"
      },
      {
        "slug": "tars1",
        "symbol": "TARS1",
        "hgnc": "HGNC:11572",
        "name": "threonyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tars1"
      },
      {
        "slug": "tp53rk",
        "symbol": "TP53RK",
        "hgnc": "HGNC:16197",
        "name": "TP53 regulating kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53rk"
      },
      {
        "slug": "tprkb",
        "symbol": "TPRKB",
        "hgnc": "HGNC:24259",
        "name": "TP53RK binding protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tprkb"
      },
      {
        "slug": "trmt10a",
        "symbol": "TRMT10A",
        "hgnc": "HGNC:28403",
        "name": "tRNA methyltransferase 10A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt10a"
      },
      {
        "slug": "twist1",
        "symbol": "TWIST1",
        "hgnc": "HGNC:12428",
        "name": "twist family bHLH transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twist1"
      },
      {
        "slug": "wdr4",
        "symbol": "WDR4",
        "hgnc": "HGNC:12756",
        "name": "WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr4"
      },
      {
        "slug": "wdr73",
        "symbol": "WDR73",
        "hgnc": "HGNC:25928",
        "name": "WD repeat domain 73",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr73"
      },
      {
        "slug": "yrdc",
        "symbol": "YRDC",
        "hgnc": "HGNC:28905",
        "name": "yrdC N6-threonylcarbamoyltransferase domain containing",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yrdc"
      },
      {
        "slug": "znf699",
        "symbol": "ZNF699",
        "hgnc": "HGNC:24750",
        "name": "zinc finger protein 699",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf699"
      },
      {
        "slug": "ctcf",
        "symbol": "CTCF",
        "hgnc": "HGNC:13723",
        "name": "CCCTC-binding factor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctcf"
      },
      {
        "slug": "ebf3",
        "symbol": "EBF3",
        "hgnc": "HGNC:19087",
        "name": "EBF transcription factor 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebf3"
      },
      {
        "slug": "gja5",
        "symbol": "GJA5",
        "hgnc": "HGNC:4279",
        "name": "gap junction protein alpha 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja5"
      },
      {
        "slug": "gja8",
        "symbol": "GJA8",
        "hgnc": "HGNC:4281",
        "name": "gap junction protein alpha 8",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja8"
      },
      {
        "slug": "nars1",
        "symbol": "NARS1",
        "hgnc": "HGNC:7643",
        "name": "asparaginyl-tRNA synthetase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nars1"
      },
      {
        "slug": "pah",
        "symbol": "PAH",
        "hgnc": "HGNC:8582",
        "name": "phenylalanine hydroxylase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pah"
      },
      {
        "slug": "smpd4",
        "symbol": "SMPD4",
        "hgnc": "HGNC:32949",
        "name": "sphingomyelin phosphodiesterase 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smpd4"
      },
      {
        "slug": "aldh18a1",
        "symbol": "ALDH18A1",
        "hgnc": "HGNC:9722",
        "name": "aldehyde dehydrogenase 18 family member A1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh18a1"
      },
      {
        "slug": "arid1b",
        "symbol": "ARID1B",
        "hgnc": "HGNC:18040",
        "name": "AT-rich interaction domain 1B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arid1b"
      },
      {
        "slug": "bltp1",
        "symbol": "BLTP1",
        "hgnc": "HGNC:26953",
        "name": "bridge-like lipid transfer protein family member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bltp1"
      },
      {
        "slug": "evc",
        "symbol": "EVC",
        "hgnc": "HGNC:3497",
        "name": "EvC ciliary complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/evc"
      },
      {
        "slug": "evc2",
        "symbol": "EVC2",
        "hgnc": "HGNC:19747",
        "name": "EvC ciliary complex subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/evc2"
      },
      {
        "slug": "gsc",
        "symbol": "GSC",
        "hgnc": "HGNC:4612",
        "name": "goosecoid homeobox",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gsc"
      },
      {
        "slug": "lig4",
        "symbol": "LIG4",
        "hgnc": "HGNC:6601",
        "name": "DNA ligase 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lig4"
      },
      {
        "slug": "mks1",
        "symbol": "MKS1",
        "hgnc": "HGNC:7121",
        "name": "MKS transition zone complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mks1"
      },
      {
        "slug": "nsun2",
        "symbol": "NSUN2",
        "hgnc": "HGNC:25994",
        "name": "NOP2/Sun RNA methyltransferase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsun2"
      },
      {
        "slug": "ophn1",
        "symbol": "OPHN1",
        "hgnc": "HGNC:8148",
        "name": "oligophrenin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ophn1"
      },
      {
        "slug": "prokr2",
        "symbol": "PROKR2",
        "hgnc": "HGNC:15836",
        "name": "prokineticin receptor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prokr2"
      },
      {
        "slug": "rlim",
        "symbol": "RLIM",
        "hgnc": "HGNC:13429",
        "name": "ring finger protein, LIM domain interacting",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rlim"
      },
      {
        "slug": "septin9",
        "symbol": "SEPTIN9",
        "hgnc": "HGNC:7323",
        "name": "septin 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/septin9"
      },
      {
        "slug": "slc35a1",
        "symbol": "SLC35A1",
        "hgnc": "HGNC:11021",
        "name": "solute carrier family 35 member A1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35a1"
      },
      {
        "slug": "src",
        "symbol": "SRC",
        "hgnc": "HGNC:11283",
        "name": "SRC proto-oncogene, non-receptor tyrosine kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/src"
      },
      {
        "slug": "stim1",
        "symbol": "STIM1",
        "hgnc": "HGNC:11386",
        "name": "stromal interaction molecule 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stim1"
      },
      {
        "slug": "trrap",
        "symbol": "TRRAP",
        "hgnc": "HGNC:12347",
        "name": "transformation/transcription domain associated protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trrap"
      },
      {
        "slug": "usp9x",
        "symbol": "USP9X",
        "hgnc": "HGNC:12632",
        "name": "ubiquitin specific peptidase 9 X-linked",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp9x"
      }
    ]
  }
}