{
  "url": "https://dantelabs.com/traits/hydranencephaly",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hydranencephaly",
    "id": "HP:0002324",
    "name": "Hydranencephaly",
    "definition": "A defect of development of the brain characterized by replacement of greater portions of the cerebral hemispheres and the corpus striatum by cerebrospinal fluid (CSF) and glial tissue.",
    "synonyms": [
      "Hydrancephaly"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "anencephaly",
        "name": "Anencephaly",
        "url": "https://dantelabs.com/traits/anencephaly"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cep55",
        "symbol": "CEP55",
        "hgnc": "HGNC:1161",
        "name": "centrosomal protein 55",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep55"
      },
      {
        "slug": "esam",
        "symbol": "ESAM",
        "hgnc": "HGNC:17474",
        "name": "endothelial cell adhesion molecule",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/esam"
      },
      {
        "slug": "flvcr2",
        "symbol": "FLVCR2",
        "hgnc": "HGNC:20105",
        "name": "FLVCR choline and putative heme transporter 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flvcr2"
      },
      {
        "slug": "gpkow",
        "symbol": "GPKOW",
        "hgnc": "HGNC:30677",
        "name": "G-patch domain and KOW motifs",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpkow"
      },
      {
        "slug": "snrpb",
        "symbol": "SNRPB",
        "hgnc": "HGNC:11153",
        "name": "small nuclear ribonucleoprotein polypeptides B and B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snrpb"
      },
      {
        "slug": "wdr81",
        "symbol": "WDR81",
        "hgnc": "HGNC:26600",
        "name": "WD repeat domain 81",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr81"
      },
      {
        "slug": "nde1",
        "symbol": "NDE1",
        "hgnc": "HGNC:17619",
        "name": "nudE neurodevelopment protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nde1"
      },
      {
        "slug": "phgdh",
        "symbol": "PHGDH",
        "hgnc": "HGNC:8923",
        "name": "phosphoglycerate dehydrogenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phgdh"
      },
      {
        "slug": "tbx15",
        "symbol": "TBX15",
        "hgnc": "HGNC:11594",
        "name": "T-box transcription factor 15",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx15"
      }
    ]
  }
}