{
  "url": "https://dantelabs.com/traits/generalized-muscle-weakness",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "generalized-muscle-weakness",
    "id": "HP:0003324",
    "name": "Generalized muscle weakness",
    "definition": "Generalized weakness or decreased strength of the muscles, affecting both distal and proximal musculature.",
    "synonyms": [
      "Generalised muscle weakness",
      "Generalised weakness",
      "Generalized weakness",
      "Muscle weakness, diffuse",
      "Muscle weakness, generalised",
      "Muscle weakness, generalized"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "muscle-weakness",
        "name": "Muscle weakness",
        "url": "https://dantelabs.com/traits/muscle-weakness"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "acta1",
        "symbol": "ACTA1",
        "hgnc": "HGNC:129",
        "name": "actin alpha 1, skeletal muscle",
        "frequency": "obligate",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/acta1"
      },
      {
        "slug": "chrnd",
        "symbol": "CHRND",
        "hgnc": "HGNC:1965",
        "name": "cholinergic receptor nicotinic delta subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrnd"
      },
      {
        "slug": "dse",
        "symbol": "DSE",
        "hgnc": "HGNC:21144",
        "name": "dermatan sulfate epimerase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dse"
      },
      {
        "slug": "fkrp",
        "symbol": "FKRP",
        "hgnc": "HGNC:17997",
        "name": "fukutin related protein",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fkrp"
      },
      {
        "slug": "fktn",
        "symbol": "FKTN",
        "hgnc": "HGNC:3622",
        "name": "fukutin",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fktn"
      },
      {
        "slug": "gaa",
        "symbol": "GAA",
        "hgnc": "HGNC:4065",
        "name": "alpha glucosidase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gaa"
      },
      {
        "slug": "lmod3",
        "symbol": "LMOD3",
        "hgnc": "HGNC:6649",
        "name": "leiomodin 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmod3"
      },
      {
        "slug": "mdga2",
        "symbol": "MDGA2",
        "hgnc": "HGNC:19835",
        "name": "MAM domain containing glycosylphosphatidylinositol anchor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdga2"
      },
      {
        "slug": "megf10",
        "symbol": "MEGF10",
        "hgnc": "HGNC:29634",
        "name": "multiple EGF like domains 10",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/megf10"
      },
      {
        "slug": "musk",
        "symbol": "MUSK",
        "hgnc": "HGNC:7525",
        "name": "muscle associated receptor tyrosine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/musk"
      },
      {
        "slug": "myl2",
        "symbol": "MYL2",
        "hgnc": "HGNC:7583",
        "name": "myosin light chain 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/myl2"
      },
      {
        "slug": "pomt2",
        "symbol": "POMT2",
        "hgnc": "HGNC:19743",
        "name": "protein O-mannosyltransferase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomt2"
      },
      {
        "slug": "rnu12",
        "symbol": "RNU12",
        "hgnc": "HGNC:19380",
        "name": "RNA, U12 small nuclear",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu12"
      },
      {
        "slug": "ryr1",
        "symbol": "RYR1",
        "hgnc": "HGNC:10483",
        "name": "ryanodine receptor 1",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ryr1"
      },
      {
        "slug": "scn4a",
        "symbol": "SCN4A",
        "hgnc": "HGNC:10591",
        "name": "sodium voltage-gated channel alpha subunit 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn4a"
      },
      {
        "slug": "sptlc1",
        "symbol": "SPTLC1",
        "hgnc": "HGNC:11277",
        "name": "serine palmitoyltransferase long chain base subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc1"
      },
      {
        "slug": "ttn",
        "symbol": "TTN",
        "hgnc": "HGNC:12403",
        "name": "titin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttn"
      },
      {
        "slug": "unc13a",
        "symbol": "UNC13A",
        "hgnc": "HGNC:23150",
        "name": "unc-13 homolog A",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/unc13a"
      },
      {
        "slug": "vcp",
        "symbol": "VCP",
        "hgnc": "HGNC:12666",
        "name": "valosin containing protein",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vcp"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "hgnc": "HGNC:8768",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aifm1"
      },
      {
        "slug": "ang",
        "symbol": "ANG",
        "hgnc": "HGNC:483",
        "name": "angiogenin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ang"
      },
      {
        "slug": "anxa11",
        "symbol": "ANXA11",
        "hgnc": "HGNC:535",
        "name": "annexin A11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/anxa11"
      },
      {
        "slug": "atxn2",
        "symbol": "ATXN2",
        "hgnc": "HGNC:10555",
        "name": "ataxin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn2"
      },
      {
        "slug": "capn3",
        "symbol": "CAPN3",
        "hgnc": "HGNC:1480",
        "name": "calpain 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/capn3"
      },
      {
        "slug": "ccnf",
        "symbol": "CCNF",
        "hgnc": "HGNC:1591",
        "name": "cyclin F",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnf"
      },
      {
        "slug": "cfap410",
        "symbol": "CFAP410",
        "hgnc": "HGNC:1260",
        "name": "cilia and flagella associated protein 410",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap410"
      },
      {
        "slug": "chchd10",
        "symbol": "CHCHD10",
        "hgnc": "HGNC:15559",
        "name": "coiled-coil-helix-coiled-coil-helix domain containing 10",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chchd10"
      },
      {
        "slug": "chmp2b",
        "symbol": "CHMP2B",
        "hgnc": "HGNC:24537",
        "name": "charged multivesicular body protein 2B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chmp2b"
      },
      {
        "slug": "col12a1",
        "symbol": "COL12A1",
        "hgnc": "HGNC:2188",
        "name": "collagen type XII alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col12a1"
      },
      {
        "slug": "col13a1",
        "symbol": "COL13A1",
        "hgnc": "HGNC:2190",
        "name": "collagen type XIII alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col13a1"
      },
      {
        "slug": "col6a1",
        "symbol": "COL6A1",
        "hgnc": "HGNC:2211",
        "name": "collagen type VI alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col6a1"
      },
      {
        "slug": "col6a2",
        "symbol": "COL6A2",
        "hgnc": "HGNC:2212",
        "name": "collagen type VI alpha 2 chain",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col6a2"
      },
      {
        "slug": "col6a3",
        "symbol": "COL6A3",
        "hgnc": "HGNC:2213",
        "name": "collagen type VI alpha 3 chain",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col6a3"
      },
      {
        "slug": "colq",
        "symbol": "COLQ",
        "hgnc": "HGNC:2226",
        "name": "collagen like tail subunit of asymmetric acetylcholinesterase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/colq"
      },
      {
        "slug": "dao",
        "symbol": "DAO",
        "hgnc": "HGNC:2671",
        "name": "D-amino acid oxidase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dao"
      },
      {
        "slug": "dctn1",
        "symbol": "DCTN1",
        "hgnc": "HGNC:2711",
        "name": "dynactin subunit 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dctn1"
      },
      {
        "slug": "dnajb6",
        "symbol": "DNAJB6",
        "hgnc": "HGNC:14888",
        "name": "DnaJ heat shock protein family (Hsp40) member B6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajb6"
      },
      {
        "slug": "erbb4",
        "symbol": "ERBB4",
        "hgnc": "HGNC:3432",
        "name": "erb-b2 receptor tyrosine kinase 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erbb4"
      },
      {
        "slug": "fig4",
        "symbol": "FIG4",
        "hgnc": "HGNC:16873",
        "name": "FIG4 phosphoinositide 5-phosphatase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fig4"
      },
      {
        "slug": "fus",
        "symbol": "FUS",
        "hgnc": "HGNC:4010",
        "name": "FUS RNA binding protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fus"
      },
      {
        "slug": "gle1",
        "symbol": "GLE1",
        "hgnc": "HGNC:4315",
        "name": "GLE1 RNA export mediator",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gle1"
      },
      {
        "slug": "glt8d1",
        "symbol": "GLT8D1",
        "hgnc": "HGNC:24870",
        "name": "glycosyltransferase 8 domain containing 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glt8d1"
      },
      {
        "slug": "hnrnpa1",
        "symbol": "HNRNPA1",
        "hgnc": "HGNC:5031",
        "name": "heterogeneous nuclear ribonucleoprotein A1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnrnpa1"
      },
      {
        "slug": "klhl41",
        "symbol": "KLHL41",
        "hgnc": "HGNC:16905",
        "name": "kelch like family member 41",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl41"
      },
      {
        "slug": "lamb2",
        "symbol": "LAMB2",
        "hgnc": "HGNC:6487",
        "name": "laminin subunit beta 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb2"
      },
      {
        "slug": "lrp12",
        "symbol": "LRP12",
        "hgnc": "HGNC:31708",
        "name": "LDL receptor related protein 12",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp12"
      },
      {
        "slug": "matr3",
        "symbol": "MATR3",
        "hgnc": "HGNC:6912",
        "name": "matrin 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/matr3"
      },
      {
        "slug": "neb",
        "symbol": "NEB",
        "hgnc": "HGNC:7720",
        "name": "nebulin",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/neb"
      },
      {
        "slug": "nefh",
        "symbol": "NEFH",
        "hgnc": "HGNC:7737",
        "name": "neurofilament heavy chain",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nefh"
      },
      {
        "slug": "nek1",
        "symbol": "NEK1",
        "hgnc": "HGNC:7744",
        "name": "NIMA related kinase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek1"
      },
      {
        "slug": "optn",
        "symbol": "OPTN",
        "hgnc": "HGNC:17142",
        "name": "optineurin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/optn"
      },
      {
        "slug": "orai1",
        "symbol": "ORAI1",
        "hgnc": "HGNC:25896",
        "name": "ORAI calcium release-activated calcium modulator 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/orai1"
      },
      {
        "slug": "pfn1",
        "symbol": "PFN1",
        "hgnc": "HGNC:8881",
        "name": "profilin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pfn1"
      },
      {
        "slug": "prph",
        "symbol": "PRPH",
        "hgnc": "HGNC:9461",
        "name": "peripherin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prph"
      },
      {
        "slug": "sod1",
        "symbol": "SOD1",
        "hgnc": "HGNC:11179",
        "name": "superoxide dismutase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sod1"
      },
      {
        "slug": "sqstm1",
        "symbol": "SQSTM1",
        "hgnc": "HGNC:11280",
        "name": "sequestosome 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sqstm1"
      },
      {
        "slug": "taf15",
        "symbol": "TAF15",
        "hgnc": "HGNC:11547",
        "name": "TATA-box binding protein associated factor 15",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf15"
      },
      {
        "slug": "tardbp",
        "symbol": "TARDBP",
        "hgnc": "HGNC:11571",
        "name": "TAR DNA binding protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tardbp"
      },
      {
        "slug": "tbk1",
        "symbol": "TBK1",
        "hgnc": "HGNC:11584",
        "name": "TANK binding kinase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbk1"
      },
      {
        "slug": "tpm3",
        "symbol": "TPM3",
        "hgnc": "HGNC:12012",
        "name": "tropomyosin 3",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/tpm3"
      },
      {
        "slug": "trem2",
        "symbol": "TREM2",
        "hgnc": "HGNC:17761",
        "name": "triggering receptor expressed on myeloid cells 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trem2"
      },
      {
        "slug": "ubqln2",
        "symbol": "UBQLN2",
        "hgnc": "HGNC:12509",
        "name": "ubiquilin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubqln2"
      },
      {
        "slug": "vapb",
        "symbol": "VAPB",
        "hgnc": "HGNC:12649",
        "name": "VAMP associated protein B and C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vapb"
      },
      {
        "slug": "aars2",
        "symbol": "AARS2",
        "hgnc": "HGNC:21022",
        "name": "alanyl-tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aars2"
      },
      {
        "slug": "acad9",
        "symbol": "ACAD9",
        "hgnc": "HGNC:21497",
        "name": "acyl-CoA dehydrogenase family member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acad9"
      },
      {
        "slug": "acy1",
        "symbol": "ACY1",
        "hgnc": "HGNC:177",
        "name": "aminoacylase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acy1"
      },
      {
        "slug": "adcy5",
        "symbol": "ADCY5",
        "hgnc": "HGNC:236",
        "name": "adenylate cyclase 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adcy5"
      },
      {
        "slug": "agk",
        "symbol": "AGK",
        "hgnc": "HGNC:21869",
        "name": "acylglycerol kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/agk"
      },
      {
        "slug": "bag3",
        "symbol": "BAG3",
        "hgnc": "HGNC:939",
        "name": "BAG cochaperone 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bag3"
      },
      {
        "slug": "ccnd1",
        "symbol": "CCND1",
        "hgnc": "HGNC:1582",
        "name": "cyclin D1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnd1"
      },
      {
        "slug": "chrna1",
        "symbol": "CHRNA1",
        "hgnc": "HGNC:1955",
        "name": "cholinergic receptor nicotinic alpha 1 subunit",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/chrna1"
      },
      {
        "slug": "coa8",
        "symbol": "COA8",
        "hgnc": "HGNC:20492",
        "name": "cytochrome c oxidase assembly factor 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coa8"
      },
      {
        "slug": "crppa",
        "symbol": "CRPPA",
        "hgnc": "HGNC:37276",
        "name": "CDP-L-ribitol pyrophosphorylase A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crppa"
      },
      {
        "slug": "exosc9",
        "symbol": "EXOSC9",
        "hgnc": "HGNC:9137",
        "name": "exosome component 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/exosc9"
      },
      {
        "slug": "htt",
        "symbol": "HTT",
        "hgnc": "HGNC:4851",
        "name": "huntingtin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htt"
      },
      {
        "slug": "iba57",
        "symbol": "IBA57",
        "hgnc": "HGNC:27302",
        "name": "iron-sulfur cluster assembly factor IBA57",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iba57"
      },
      {
        "slug": "men1",
        "symbol": "MEN1",
        "hgnc": "HGNC:7010",
        "name": "menin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/men1"
      },
      {
        "slug": "myl1",
        "symbol": "MYL1",
        "hgnc": "HGNC:7582",
        "name": "myosin light chain 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myl1"
      },
      {
        "slug": "pomt1",
        "symbol": "POMT1",
        "hgnc": "HGNC:9202",
        "name": "protein O-mannosyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomt1"
      },
      {
        "slug": "ranbp2",
        "symbol": "RANBP2",
        "hgnc": "HGNC:9848",
        "name": "RAN binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ranbp2"
      },
      {
        "slug": "sdha",
        "symbol": "SDHA",
        "hgnc": "HGNC:10680",
        "name": "succinate dehydrogenase complex flavoprotein subunit A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdha"
      },
      {
        "slug": "sdhaf1",
        "symbol": "SDHAF1",
        "hgnc": "HGNC:33867",
        "name": "succinate dehydrogenase complex assembly factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhaf1"
      },
      {
        "slug": "sdhb",
        "symbol": "SDHB",
        "hgnc": "HGNC:10681",
        "name": "succinate dehydrogenase complex iron sulfur subunit B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhb"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "slc2a3",
        "symbol": "SLC2A3",
        "hgnc": "HGNC:11007",
        "name": "solute carrier family 2 member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a3"
      },
      {
        "slug": "yy1",
        "symbol": "YY1",
        "hgnc": "HGNC:12856",
        "name": "YY1 transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yy1"
      },
      {
        "slug": "atp13a2",
        "symbol": "ATP13A2",
        "hgnc": "HGNC:30213",
        "name": "ATPase cation transporting 13A2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp13a2"
      },
      {
        "slug": "dmd",
        "symbol": "DMD",
        "hgnc": "HGNC:2928",
        "name": "dystrophin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dmd"
      },
      {
        "slug": "hacd1",
        "symbol": "HACD1",
        "hgnc": "HGNC:9639",
        "name": "3-hydroxyacyl-CoA dehydratase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hacd1"
      },
      {
        "slug": "hadha",
        "symbol": "HADHA",
        "hgnc": "HGNC:4801",
        "name": "hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hadha"
      },
      {
        "slug": "hadhb",
        "symbol": "HADHB",
        "hgnc": "HGNC:4803",
        "name": "hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hadhb"
      },
      {
        "slug": "itga7",
        "symbol": "ITGA7",
        "hgnc": "HGNC:6143",
        "name": "integrin subunit alpha 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga7"
      },
      {
        "slug": "map3k20",
        "symbol": "MAP3K20",
        "hgnc": "HGNC:17797",
        "name": "mitogen-activated protein kinase kinase kinase 20",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k20"
      },
      {
        "slug": "morc2",
        "symbol": "MORC2",
        "hgnc": "HGNC:23573",
        "name": "MORC family CW-type zinc finger 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/morc2"
      },
      {
        "slug": "pign",
        "symbol": "PIGN",
        "hgnc": "HGNC:8967",
        "name": "phosphatidylinositol glycan anchor biosynthesis class N",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pign"
      },
      {
        "slug": "plec",
        "symbol": "PLEC",
        "hgnc": "HGNC:9069",
        "name": "plectin",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/plec"
      },
      {
        "slug": "plod1",
        "symbol": "PLOD1",
        "hgnc": "HGNC:9081",
        "name": "procollagen-lysine,2-oxoglutarate 5-dioxygenase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plod1"
      },
      {
        "slug": "pnkd",
        "symbol": "PNKD",
        "hgnc": "HGNC:9153",
        "name": "PNKD metallo-beta-lactamase domain containing",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnkd"
      },
      {
        "slug": "prrt2",
        "symbol": "PRRT2",
        "hgnc": "HGNC:30500",
        "name": "proline rich transmembrane protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prrt2"
      },
      {
        "slug": "rapsn",
        "symbol": "RAPSN",
        "hgnc": "HGNC:9863",
        "name": "receptor associated protein of the synapse",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rapsn"
      },
      {
        "slug": "selenon",
        "symbol": "SELENON",
        "hgnc": "HGNC:15999",
        "name": "selenoprotein N",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/selenon"
      },
      {
        "slug": "slc16a2",
        "symbol": "SLC16A2",
        "hgnc": "HGNC:10923",
        "name": "solute carrier family 16 member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc16a2"
      },
      {
        "slug": "slc52a3",
        "symbol": "SLC52A3",
        "hgnc": "HGNC:16187",
        "name": "solute carrier family 52 member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc52a3"
      },
      {
        "slug": "tpm2",
        "symbol": "TPM2",
        "hgnc": "HGNC:12011",
        "name": "tropomyosin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpm2"
      },
      {
        "slug": "uba1",
        "symbol": "UBA1",
        "hgnc": "HGNC:12469",
        "name": "ubiquitin like modifier activating enzyme 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uba1"
      },
      {
        "slug": "ldb3",
        "symbol": "LDB3",
        "hgnc": "HGNC:15710",
        "name": "LIM domain binding 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldb3"
      },
      {
        "slug": "abcb6",
        "symbol": "ABCB6",
        "hgnc": "HGNC:47",
        "name": "ATP binding cassette subfamily B member 6 (LAN blood group)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb6"
      },
      {
        "slug": "cavin1",
        "symbol": "CAVIN1",
        "hgnc": "HGNC:9688",
        "name": "caveolae associated protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cavin1"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcnkb"
      },
      {
        "slug": "fgf23",
        "symbol": "FGF23",
        "hgnc": "HGNC:3680",
        "name": "fibroblast growth factor 23",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf23"
      },
      {
        "slug": "fxyd2",
        "symbol": "FXYD2",
        "hgnc": "HGNC:4026",
        "name": "FXYD domain containing ion transport regulator 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fxyd2"
      },
      {
        "slug": "kcnj1",
        "symbol": "KCNJ1",
        "hgnc": "HGNC:6255",
        "name": "potassium inwardly rectifying channel subfamily J member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj1"
      },
      {
        "slug": "mtm1",
        "symbol": "MTM1",
        "hgnc": "HGNC:7448",
        "name": "myotubularin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtm1"
      },
      {
        "slug": "myh2",
        "symbol": "MYH2",
        "hgnc": "HGNC:7572",
        "name": "myosin heavy chain 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh2"
      },
      {
        "slug": "myh7",
        "symbol": "MYH7",
        "hgnc": "HGNC:7577",
        "name": "myosin heavy chain 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh7"
      },
      {
        "slug": "pla2g6",
        "symbol": "PLA2G6",
        "hgnc": "HGNC:9039",
        "name": "phospholipase A2 group VI",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pla2g6"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "pomgnt1",
        "symbol": "POMGNT1",
        "hgnc": "HGNC:19139",
        "name": "protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomgnt1"
      },
      {
        "slug": "slc12a1",
        "symbol": "SLC12A1",
        "hgnc": "HGNC:10910",
        "name": "solute carrier family 12 member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a1"
      },
      {
        "slug": "slc12a3",
        "symbol": "SLC12A3",
        "hgnc": "HGNC:10912",
        "name": "solute carrier family 12 member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a3"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "twnk",
        "symbol": "TWNK",
        "hgnc": "HGNC:1160",
        "name": "twinkle mtDNA helicase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twnk"
      }
    ]
  }
}