{
  "url": "https://dantelabs.com/traits/diastema",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "diastema",
    "id": "HP:0000699",
    "name": "Gap between teeth",
    "label": "Diastema",
    "definition": "Increased space between two adjacent teeth in the same dental arch.",
    "synonyms": [
      "Gaps between teeth",
      "Dental diastasis",
      "Dental diastema",
      "Diastasis of the teeth",
      "Diastema of the teeth"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "tooth-malposition",
        "name": "Abnormal dental position",
        "url": "https://dantelabs.com/traits/tooth-malposition"
      }
    ],
    "narrower": [
      {
        "slug": "widely-spaced-incisors",
        "name": "Gap between front teeth",
        "genes": 4,
        "url": "https://dantelabs.com/traits/widely-spaced-incisors"
      }
    ],
    "genes": [
      {
        "slug": "atrx",
        "symbol": "ATRX",
        "hgnc": "HGNC:886",
        "name": "ATRX chromatin remodeler",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atrx"
      },
      {
        "slug": "kdm6b",
        "symbol": "KDM6B",
        "hgnc": "HGNC:29012",
        "name": "lysine demethylase 6B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6b"
      },
      {
        "slug": "kcnma1",
        "symbol": "KCNMA1",
        "hgnc": "HGNC:6284",
        "name": "potassium calcium-activated channel subfamily M alpha 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnma1"
      },
      {
        "slug": "naa80",
        "symbol": "NAA80",
        "hgnc": "HGNC:30252",
        "name": "N-alpha-acetyltransferase 80, NatH catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naa80"
      },
      {
        "slug": "prkaca",
        "symbol": "PRKACA",
        "hgnc": "HGNC:9380",
        "name": "protein kinase cAMP-activated catalytic subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkaca"
      },
      {
        "slug": "rdh11",
        "symbol": "RDH11",
        "hgnc": "HGNC:17964",
        "name": "retinol dehydrogenase 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rdh11"
      },
      {
        "slug": "actl6b",
        "symbol": "ACTL6B",
        "hgnc": "HGNC:160",
        "name": "actin like 6B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actl6b"
      },
      {
        "slug": "arsk",
        "symbol": "ARSK",
        "hgnc": "HGNC:25239",
        "name": "arylsulfatase family member K",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arsk"
      },
      {
        "slug": "fem1b",
        "symbol": "FEM1B",
        "hgnc": "HGNC:3649",
        "name": "fem-1 homolog B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fem1b"
      },
      {
        "slug": "gtf3c3",
        "symbol": "GTF3C3",
        "hgnc": "HGNC:4666",
        "name": "general transcription factor IIIC subunit 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtf3c3"
      },
      {
        "slug": "kdm5c",
        "symbol": "KDM5C",
        "hgnc": "HGNC:11114",
        "name": "lysine demethylase 5C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm5c"
      },
      {
        "slug": "lrrc7",
        "symbol": "LRRC7",
        "hgnc": "HGNC:18531",
        "name": "leucine rich repeat containing 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc7"
      },
      {
        "slug": "nhs",
        "symbol": "NHS",
        "hgnc": "HGNC:7820",
        "name": "NHS actin remodeling regulator",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nhs"
      },
      {
        "slug": "pacs1",
        "symbol": "PACS1",
        "hgnc": "HGNC:30032",
        "name": "phosphofurin acidic cluster sorting protein 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pacs1"
      },
      {
        "slug": "smc5",
        "symbol": "SMC5",
        "hgnc": "HGNC:20465",
        "name": "structural maintenance of chromosomes 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smc5"
      },
      {
        "slug": "tcf12",
        "symbol": "TCF12",
        "hgnc": "HGNC:11623",
        "name": "transcription factor 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf12"
      },
      {
        "slug": "chsy1",
        "symbol": "CHSY1",
        "hgnc": "HGNC:17198",
        "name": "chondroitin sulfate synthase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chsy1"
      },
      {
        "slug": "ift57",
        "symbol": "IFT57",
        "hgnc": "HGNC:17367",
        "name": "intraflagellar transport 57",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift57"
      },
      {
        "slug": "mgat2",
        "symbol": "MGAT2",
        "hgnc": "HGNC:7045",
        "name": "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mgat2"
      },
      {
        "slug": "ube3b",
        "symbol": "UBE3B",
        "hgnc": "HGNC:13478",
        "name": "ubiquitin protein ligase E3B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube3b"
      }
    ]
  }
}