{
  "url": "https://dantelabs.com/traits/d-2-hydroxyglutaric-aciduria",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "d-2-hydroxyglutaric-aciduria",
    "id": "HP:0012321",
    "name": "D-2-hydroxyglutaric aciduria",
    "definition": "An increased concentration of 2-hydroxyglutaric acid in the urine.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "2-hydroxyglutarate-aciduria",
        "name": "2-hydroxyglutarate aciduria",
        "url": "https://dantelabs.com/traits/2-hydroxyglutarate-aciduria"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "d2hgdh",
        "symbol": "D2HGDH",
        "hgnc": "HGNC:28358",
        "name": "D-2-hydroxyglutarate dehydrogenase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/d2hgdh"
      },
      {
        "slug": "idh1",
        "symbol": "IDH1",
        "hgnc": "HGNC:5382",
        "name": "isocitrate dehydrogenase (NADP(+)) 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idh1"
      },
      {
        "slug": "idh2",
        "symbol": "IDH2",
        "hgnc": "HGNC:5383",
        "name": "isocitrate dehydrogenase (NADP(+)) 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/idh2"
      }
    ]
  }
}