{
  "url": "https://dantelabs.com/traits/cortical-sclerosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "cortical-sclerosis",
    "id": "HP:0005652",
    "name": "Cortical sclerosis",
    "definition": "Sclerosis (abnormal hardening) of cortical bone, characterized by increased radiodensity.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cortical-bone-morphology",
        "name": "Abnormal cortical bone morphology",
        "url": "https://dantelabs.com/traits/abnormal-cortical-bone-morphology"
      },
      {
        "slug": "increased-bone-mineral-density",
        "name": "Increased bone mineral density",
        "url": "https://dantelabs.com/traits/increased-bone-mineral-density"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "slc4a2",
        "symbol": "SLC4A2",
        "hgnc": "HGNC:11028",
        "name": "solute carrier family 4 member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc4a2"
      },
      {
        "slug": "sost",
        "symbol": "SOST",
        "hgnc": "HGNC:13771",
        "name": "sclerostin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sost"
      },
      {
        "slug": "clcn7",
        "symbol": "CLCN7",
        "hgnc": "HGNC:2025",
        "name": "Cl-/H+ antiporter 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcn7"
      },
      {
        "slug": "plekhm1",
        "symbol": "PLEKHM1",
        "hgnc": "HGNC:29017",
        "name": "pleckstrin homology and RUN domain containing M1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plekhm1"
      },
      {
        "slug": "tcirg1",
        "symbol": "TCIRG1",
        "hgnc": "HGNC:11647",
        "name": "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcirg1"
      }
    ]
  }
}