{
  "url": "https://dantelabs.com/traits/conjunctival-icterus",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "conjunctival-icterus",
    "id": "HP:0032106",
    "name": "Yellowing of the whites of the eyes",
    "label": "Conjunctival icterus",
    "definition": "Conjunctival icterus is a condition where there is yellowing of the whites of the eyes. This is most commonly seen in patients who have liver disease.",
    "synonyms": [
      "Scleral icterus",
      "Yellow conjunctiva",
      "Yellow sclera"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-conjunctiva-morphology",
        "name": "Abnormal conjunctiva morphology",
        "url": "https://dantelabs.com/traits/abnormal-conjunctiva-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dst",
        "symbol": "DST",
        "hgnc": "HGNC:1090",
        "name": "dystonin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dst"
      },
      {
        "slug": "tmem63b",
        "symbol": "TMEM63B",
        "hgnc": "HGNC:17735",
        "name": "transmembrane protein 63B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem63b"
      },
      {
        "slug": "ubr1",
        "symbol": "UBR1",
        "hgnc": "HGNC:16808",
        "name": "ubiquitin protein ligase E3 component n-recognin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubr1"
      },
      {
        "slug": "fh",
        "symbol": "FH",
        "hgnc": "HGNC:3700",
        "name": "fumarate hydratase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fh"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "pkhd1",
        "symbol": "PKHD1",
        "hgnc": "HGNC:9016",
        "name": "PKHD1 ciliary IPT domain containing fibrocystin/polyductin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkhd1"
      },
      {
        "slug": "slco1b1",
        "symbol": "SLCO1B1",
        "hgnc": "HGNC:10959",
        "name": "solute carrier organic anion transporter family member 1B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slco1b1"
      },
      {
        "slug": "slco1b3",
        "symbol": "SLCO1B3",
        "hgnc": "HGNC:10961",
        "name": "solute carrier organic anion transporter family member 1B3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slco1b3"
      },
      {
        "slug": "piezo1",
        "symbol": "PIEZO1",
        "hgnc": "HGNC:28993",
        "name": "piezo type mechanosensitive ion channel component 1 (Er blood group)",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piezo1"
      }
    ]
  }
}