{
  "url": "https://dantelabs.com/traits/compensated-hypothyroidism",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "compensated-hypothyroidism",
    "id": "HP:0008223",
    "name": "Compensated hypothyroidism",
    "definition": "Condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine (FT4).",
    "synonyms": [
      "Mild hypothyroidism",
      "Subclinical hypothyroidism"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "thrb",
        "symbol": "THRB",
        "hgnc": "HGNC:11799",
        "name": "thyroid hormone receptor beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thrb"
      },
      {
        "slug": "tango2",
        "symbol": "TANGO2",
        "hgnc": "HGNC:25439",
        "name": "transport and golgi organization 2 homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tango2"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "hgnc": "HGNC:12269",
        "name": "three prime repair exonuclease 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trex1"
      },
      {
        "slug": "nkx2-1",
        "symbol": "NKX2-1",
        "hgnc": "HGNC:11825",
        "name": "NK2 homeobox 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nkx2-1"
      },
      {
        "slug": "tshr",
        "symbol": "TSHR",
        "hgnc": "HGNC:12373",
        "name": "thyroid stimulating hormone receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tshr"
      },
      {
        "slug": "foxi1",
        "symbol": "FOXI1",
        "hgnc": "HGNC:3815",
        "name": "forkhead box I1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxi1"
      },
      {
        "slug": "kcnj10",
        "symbol": "KCNJ10",
        "hgnc": "HGNC:6256",
        "name": "potassium inwardly rectifying channel subfamily J member 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj10"
      },
      {
        "slug": "slc26a4",
        "symbol": "SLC26A4",
        "hgnc": "HGNC:8818",
        "name": "solute carrier family 26 member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a4"
      },
      {
        "slug": "tg",
        "symbol": "TG",
        "hgnc": "HGNC:11764",
        "name": "thyroglobulin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tg"
      }
    ]
  }
}