{
  "url": "https://dantelabs.com/traits/cerebral-hypomyelination",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "cerebral-hypomyelination",
    "id": "HP:0006808",
    "name": "Cerebral hypomyelination",
    "definition": "Reduced amount of myelin in the nervous system resulting from defective myelinogenesis in the white matter of the central nervous system.",
    "synonyms": [
      "Hypomyelination of the brain"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "cns-hypomyelination",
        "name": "CNS hypomyelination",
        "url": "https://dantelabs.com/traits/cns-hypomyelination"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "bcap31",
        "symbol": "BCAP31",
        "hgnc": "HGNC:16695",
        "name": "B cell receptor associated protein 31",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/bcap31"
      },
      {
        "slug": "mthfs",
        "symbol": "MTHFS",
        "hgnc": "HGNC:7437",
        "name": "methenyltetrahydrofolate synthetase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mthfs"
      },
      {
        "slug": "slc25a12",
        "symbol": "SLC25A12",
        "hgnc": "HGNC:10982",
        "name": "solute carrier family 25 member 12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a12"
      },
      {
        "slug": "hycc1",
        "symbol": "HYCC1",
        "hgnc": "HGNC:24587",
        "name": "hyccin PI4KA lipid kinase complex subunit 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hycc1"
      },
      {
        "slug": "plp1",
        "symbol": "PLP1",
        "hgnc": "HGNC:9086",
        "name": "proteolipid protein 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/plp1"
      },
      {
        "slug": "afg2a",
        "symbol": "AFG2A",
        "hgnc": "HGNC:18119",
        "name": "AAA ATPase AFG2A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/afg2a"
      },
      {
        "slug": "phgdh",
        "symbol": "PHGDH",
        "hgnc": "HGNC:8923",
        "name": "phosphoglycerate dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phgdh"
      },
      {
        "slug": "rars1",
        "symbol": "RARS1",
        "hgnc": "HGNC:9870",
        "name": "arginyl-tRNA synthetase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rars1"
      },
      {
        "slug": "tbcd",
        "symbol": "TBCD",
        "hgnc": "HGNC:11581",
        "name": "tubulin folding cofactor D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbcd"
      },
      {
        "slug": "ahdc1",
        "symbol": "AHDC1",
        "hgnc": "HGNC:25230",
        "name": "AT-hook DNA binding motif containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ahdc1"
      },
      {
        "slug": "alg2",
        "symbol": "ALG2",
        "hgnc": "HGNC:23159",
        "name": "ALG2 alpha-1,3/1,6-mannosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg2"
      },
      {
        "slug": "cyb5a",
        "symbol": "CYB5A",
        "hgnc": "HGNC:2570",
        "name": "cytochrome b5 type A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyb5a"
      },
      {
        "slug": "cyb5r3",
        "symbol": "CYB5R3",
        "hgnc": "HGNC:2873",
        "name": "cytochrome b5 reductase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyb5r3"
      },
      {
        "slug": "fh",
        "symbol": "FH",
        "hgnc": "HGNC:3700",
        "name": "fumarate hydratase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fh"
      },
      {
        "slug": "pgap2",
        "symbol": "PGAP2",
        "hgnc": "HGNC:17893",
        "name": "post-GPI attachment to proteins 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgap2"
      },
      {
        "slug": "pgap3",
        "symbol": "PGAP3",
        "hgnc": "HGNC:23719",
        "name": "post-GPI attachment to proteins phospholipase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgap3"
      },
      {
        "slug": "pigl",
        "symbol": "PIGL",
        "hgnc": "HGNC:8966",
        "name": "phosphatidylinositol glycan anchor biosynthesis class L",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigl"
      },
      {
        "slug": "pigo",
        "symbol": "PIGO",
        "hgnc": "HGNC:23215",
        "name": "phosphatidylinositol glycan anchor biosynthesis class O",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigo"
      },
      {
        "slug": "pigv",
        "symbol": "PIGV",
        "hgnc": "HGNC:26031",
        "name": "phosphatidylinositol glycan anchor biosynthesis class V",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigv"
      },
      {
        "slug": "pigw",
        "symbol": "PIGW",
        "hgnc": "HGNC:23213",
        "name": "phosphatidylinositol glycan anchor biosynthesis class W",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigw"
      },
      {
        "slug": "pigy",
        "symbol": "PIGY",
        "hgnc": "HGNC:28213",
        "name": "phosphatidylinositol glycan anchor biosynthesis class Y",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigy"
      },
      {
        "slug": "slc1a4",
        "symbol": "SLC1A4",
        "hgnc": "HGNC:10942",
        "name": "solute carrier family 1 member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc1a4"
      },
      {
        "slug": "tmtc3",
        "symbol": "TMTC3",
        "hgnc": "HGNC:26899",
        "name": "transmembrane O-mannosyltransferase targeting cadherins 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmtc3"
      },
      {
        "slug": "wdr26",
        "symbol": "WDR26",
        "hgnc": "HGNC:21208",
        "name": "WD repeat domain 26",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr26"
      },
      {
        "slug": "adsl",
        "symbol": "ADSL",
        "hgnc": "HGNC:291",
        "name": "adenylosuccinate lyase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adsl"
      },
      {
        "slug": "eif2b1",
        "symbol": "EIF2B1",
        "hgnc": "HGNC:3257",
        "name": "eukaryotic translation initiation factor 2B subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2b1"
      },
      {
        "slug": "gjc2",
        "symbol": "GJC2",
        "hgnc": "HGNC:17494",
        "name": "gap junction protein gamma 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjc2"
      },
      {
        "slug": "polr3b",
        "symbol": "POLR3B",
        "hgnc": "HGNC:30348",
        "name": "RNA polymerase III subunit B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3b"
      },
      {
        "slug": "sox10",
        "symbol": "SOX10",
        "hgnc": "HGNC:11190",
        "name": "SRY-box transcription factor 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox10"
      },
      {
        "slug": "stxbp1",
        "symbol": "STXBP1",
        "hgnc": "HGNC:11444",
        "name": "syntaxin binding protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stxbp1"
      },
      {
        "slug": "tubb4a",
        "symbol": "TUBB4A",
        "hgnc": "HGNC:20774",
        "name": "tubulin beta 4A class IVa",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tubb4a"
      },
      {
        "slug": "vps11",
        "symbol": "VPS11",
        "hgnc": "HGNC:14583",
        "name": "VPS11 core subunit of CORVET and HOPS complexes",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps11"
      }
    ]
  }
}