{
  "url": "https://dantelabs.com/traits/aphthous-ulcer",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "aphthous-ulcer",
    "id": "HP:0032154",
    "name": "Canker sore",
    "label": "Aphthous ulcer",
    "definition": "Oral aphthous ulcers typically present as painful, sharply circumscribed fibrin-covered mucosal defects with a hyperemic border.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "erosion-of-oral-mucosa",
        "name": "Erosion of oral mucosa",
        "url": "https://dantelabs.com/traits/erosion-of-oral-mucosa"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "il21",
        "symbol": "IL21",
        "hgnc": "HGNC:6005",
        "name": "interleukin 21",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il21"
      },
      {
        "slug": "nlrp3",
        "symbol": "NLRP3",
        "hgnc": "HGNC:16400",
        "name": "NLR family pyrin domain containing 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nlrp3"
      },
      {
        "slug": "sec61a1",
        "symbol": "SEC61A1",
        "hgnc": "HGNC:18276",
        "name": "SEC61 translocon subunit alpha 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec61a1"
      },
      {
        "slug": "slc19a1",
        "symbol": "SLC19A1",
        "hgnc": "HGNC:10937",
        "name": "solute carrier family 19 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc19a1"
      },
      {
        "slug": "sash3",
        "symbol": "SASH3",
        "hgnc": "HGNC:15975",
        "name": "SAM and SH3 domain containing 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sash3"
      },
      {
        "slug": "ada2",
        "symbol": "ADA2",
        "hgnc": "HGNC:1839",
        "name": "adenosine deaminase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ada2"
      },
      {
        "slug": "mefv",
        "symbol": "MEFV",
        "hgnc": "HGNC:6998",
        "name": "MEFV innate immunity regulator, pyrin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mefv"
      },
      {
        "slug": "il6",
        "symbol": "IL6",
        "hgnc": "HGNC:6018",
        "name": "interleukin 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il6"
      },
      {
        "slug": "nod2",
        "symbol": "NOD2",
        "hgnc": "HGNC:5331",
        "name": "nucleotide binding oligomerization domain containing 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nod2"
      }
    ]
  }
}