{
  "url": "https://dantelabs.com/traits/anemic-pallor",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "anemic-pallor",
    "id": "HP:0001017",
    "name": "Anemic pallor",
    "definition": "A type of pallor that is secondary to the presence of anemia.",
    "synonyms": [
      "Anaemic pallor"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "pallor",
        "name": "Paleness",
        "url": "https://dantelabs.com/traits/pallor"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "alas2",
        "symbol": "ALAS2",
        "hgnc": "HGNC:397",
        "name": "5'-aminolevulinate synthase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alas2"
      },
      {
        "slug": "bmpr1a",
        "symbol": "BMPR1A",
        "hgnc": "HGNC:1076",
        "name": "bone morphogenetic protein receptor type 1A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr1a"
      },
      {
        "slug": "eng",
        "symbol": "ENG",
        "hgnc": "HGNC:3349",
        "name": "endoglin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eng"
      },
      {
        "slug": "slc4a1",
        "symbol": "SLC4A1",
        "hgnc": "HGNC:11027",
        "name": "solute carrier family 4 member 1 (Diego blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc4a1"
      },
      {
        "slug": "smad4",
        "symbol": "SMAD4",
        "hgnc": "HGNC:6770",
        "name": "SMAD family member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad4"
      },
      {
        "slug": "alk",
        "symbol": "ALK",
        "hgnc": "HGNC:427",
        "name": "ALK receptor tyrosine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alk"
      },
      {
        "slug": "hace1",
        "symbol": "HACE1",
        "hgnc": "HGNC:21033",
        "name": "HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hace1"
      },
      {
        "slug": "lin28b",
        "symbol": "LIN28B",
        "hgnc": "HGNC:32207",
        "name": "lin-28 RNA binding posttranscriptional regulator B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lin28b"
      },
      {
        "slug": "lmo1",
        "symbol": "LMO1",
        "hgnc": "HGNC:6641",
        "name": "LIM domain only 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmo1"
      },
      {
        "slug": "mycn",
        "symbol": "MYCN",
        "hgnc": "HGNC:7559",
        "name": "MYCN proto-oncogene, bHLH transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mycn"
      },
      {
        "slug": "phox2b",
        "symbol": "PHOX2B",
        "hgnc": "HGNC:9143",
        "name": "paired like homeobox 2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phox2b"
      },
      {
        "slug": "tmprss6",
        "symbol": "TMPRSS6",
        "hgnc": "HGNC:16517",
        "name": "transmembrane serine protease 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmprss6"
      },
      {
        "slug": "fanca",
        "symbol": "FANCA",
        "hgnc": "HGNC:3582",
        "name": "FA complementation group A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fanca"
      },
      {
        "slug": "fancc",
        "symbol": "FANCC",
        "hgnc": "HGNC:3584",
        "name": "FA complementation group C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancc"
      },
      {
        "slug": "fancd2",
        "symbol": "FANCD2",
        "hgnc": "HGNC:3585",
        "name": "FA complementation group D2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancd2"
      },
      {
        "slug": "fance",
        "symbol": "FANCE",
        "hgnc": "HGNC:3586",
        "name": "FA complementation group E",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fance"
      }
    ]
  }
}