{
  "url": "https://dantelabs.com/traits/allergic-rhinitis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "allergic-rhinitis",
    "id": "HP:0003193",
    "name": "Hay fever",
    "label": "Allergic rhinitis",
    "definition": "It is characterized by one or more symptoms including sneezing, itching, nasal congestion, and rhinorrhea.",
    "synonyms": [
      "Hayfever",
      "Nasal allergies"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "allergy",
        "name": "Allergy",
        "url": "https://dantelabs.com/traits/allergy"
      },
      {
        "slug": "rhinitis",
        "name": "Nasal inflammation",
        "url": "https://dantelabs.com/traits/rhinitis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "sik3",
        "symbol": "SIK3",
        "hgnc": "HGNC:29165",
        "name": "SIK family kinase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sik3"
      },
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "pgm3",
        "symbol": "PGM3",
        "hgnc": "HGNC:8907",
        "name": "phosphoglucomutase 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pgm3"
      },
      {
        "slug": "plcg2",
        "symbol": "PLCG2",
        "hgnc": "HGNC:9066",
        "name": "phospholipase C gamma 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plcg2"
      },
      {
        "slug": "carmil2",
        "symbol": "CARMIL2",
        "hgnc": "HGNC:27089",
        "name": "capping protein regulator and myosin 1 linker 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/carmil2"
      },
      {
        "slug": "cdsn",
        "symbol": "CDSN",
        "hgnc": "HGNC:1802",
        "name": "corneodesmosin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdsn"
      },
      {
        "slug": "cox4i2",
        "symbol": "COX4I2",
        "hgnc": "HGNC:16232",
        "name": "cytochrome c oxidase subunit 4I2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox4i2"
      },
      {
        "slug": "dock8",
        "symbol": "DOCK8",
        "hgnc": "HGNC:19191",
        "name": "dedicator of cytokinesis 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock8"
      },
      {
        "slug": "ighg2",
        "symbol": "IGHG2",
        "hgnc": "HGNC:5526",
        "name": "immunoglobulin heavy constant gamma 2 (G2m marker)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighg2"
      },
      {
        "slug": "igkc",
        "symbol": "IGKC",
        "hgnc": "HGNC:5716",
        "name": "immunoglobulin kappa constant",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igkc"
      },
      {
        "slug": "krt74",
        "symbol": "KRT74",
        "hgnc": "HGNC:28929",
        "name": "keratin 74",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt74"
      },
      {
        "slug": "slc27a4",
        "symbol": "SLC27A4",
        "hgnc": "HGNC:10998",
        "name": "solute carrier family 27 member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc27a4"
      },
      {
        "slug": "cpn1",
        "symbol": "CPN1",
        "hgnc": "HGNC:2312",
        "name": "carboxypeptidase N subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpn1"
      }
    ]
  }
}