{
  "url": "https://dantelabs.com/traits/abnormal-urinary-electrolyte-concentration",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-urinary-electrolyte-concentration",
    "id": "HP:0012591",
    "name": "Abnormal urinary electrolyte concentration",
    "definition": "An abnormality in the concentration of electrolytes in the urine.",
    "synonyms": [
      "Urinary electrolyte imbalance"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-urine-homeostasis",
        "name": "Pee issues",
        "url": "https://dantelabs.com/traits/abnormality-of-urine-homeostasis"
      }
    ],
    "narrower": [
      {
        "slug": "renal-salt-wasting",
        "name": "Loss of salt in urine",
        "genes": 22,
        "url": "https://dantelabs.com/traits/renal-salt-wasting"
      },
      {
        "slug": "abnormal-urine-potassium-concentration",
        "name": "Abnormal urine potassium concentration",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-urine-potassium-concentration"
      },
      {
        "slug": "abnormal-urine-sodium-concentration",
        "name": "Abnormal urine sodium concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-urine-sodium-concentration"
      },
      {
        "slug": "abnormal-urine-chloride-concentration",
        "name": "Abnormal urine chloride concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-urine-chloride-concentration"
      },
      {
        "slug": "abnormal-urine-magnesium-concentration",
        "name": "Abnormal urine magnesium concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-urine-magnesium-concentration"
      },
      {
        "slug": "abnormal-urine-phosphate-concentration",
        "name": "Abnormal urine phosphate concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-urine-phosphate-concentration"
      },
      {
        "slug": "abnormality-of-urine-calcium-concentration",
        "name": "Abnormality of urine calcium concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormality-of-urine-calcium-concentration"
      }
    ],
    "genes": [
      {
        "slug": "kcnj10",
        "symbol": "KCNJ10",
        "hgnc": "HGNC:6256",
        "name": "potassium inwardly rectifying channel subfamily J member 10",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj10"
      },
      {
        "slug": "alg5",
        "symbol": "ALG5",
        "hgnc": "HGNC:20266",
        "name": "ALG5 dolichyl-phosphate beta-glucosyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg5"
      },
      {
        "slug": "alg9",
        "symbol": "ALG9",
        "hgnc": "HGNC:15672",
        "name": "ALG9 alpha-1,2-mannosyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg9"
      },
      {
        "slug": "bicc1",
        "symbol": "BICC1",
        "hgnc": "HGNC:19351",
        "name": "BicC family RNA binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bicc1"
      },
      {
        "slug": "dcdc2",
        "symbol": "DCDC2",
        "hgnc": "HGNC:18141",
        "name": "doublecortin domain containing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dcdc2"
      },
      {
        "slug": "dnajb11",
        "symbol": "DNAJB11",
        "hgnc": "HGNC:14889",
        "name": "DnaJ heat shock protein family (Hsp40) member B11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajb11"
      },
      {
        "slug": "ganab",
        "symbol": "GANAB",
        "hgnc": "HGNC:4138",
        "name": "glucosidase II alpha subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ganab"
      },
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "nek8",
        "symbol": "NEK8",
        "hgnc": "HGNC:13387",
        "name": "NIMA related kinase 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek8"
      },
      {
        "slug": "pkd1",
        "symbol": "PKD1",
        "hgnc": "HGNC:9008",
        "name": "polycystin 1, transient receptor potential channel interacting",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd1"
      },
      {
        "slug": "pkd2",
        "symbol": "PKD2",
        "hgnc": "HGNC:9009",
        "name": "polycystin 2, transient receptor potential cation channel",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd2"
      },
      {
        "slug": "tmem67",
        "symbol": "TMEM67",
        "hgnc": "HGNC:28396",
        "name": "transmembrane protein 67",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem67"
      }
    ]
  }
}