{
  "url": "https://dantelabs.com/traits/abnormal-nasal-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-nasal-morphology",
    "id": "HP:0005105",
    "name": "Abnormal of nasal shape",
    "label": "Abnormal nasal morphology",
    "synonyms": [
      "Abnormal of shape of nose",
      "Abnormal nose morphology",
      "Abnormal of morphology of nose"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-nose",
        "name": "Abnormality of the nose",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nose"
      }
    ],
    "narrower": [
      {
        "slug": "short-nose",
        "name": "Short nose",
        "genes": 337,
        "url": "https://dantelabs.com/traits/short-nose"
      },
      {
        "slug": "wide-nose",
        "name": "Wide nose",
        "genes": 137,
        "url": "https://dantelabs.com/traits/wide-nose"
      },
      {
        "slug": "prominent-nose",
        "name": "Prominent nose",
        "genes": 125,
        "url": "https://dantelabs.com/traits/prominent-nose"
      },
      {
        "slug": "long-nose",
        "name": "Long nose",
        "genes": 46,
        "url": "https://dantelabs.com/traits/long-nose"
      },
      {
        "slug": "narrow-nose",
        "name": "Narrow nose",
        "genes": 30,
        "url": "https://dantelabs.com/traits/narrow-nose"
      },
      {
        "slug": "proboscis",
        "name": "Proboscis",
        "genes": 21,
        "url": "https://dantelabs.com/traits/proboscis"
      },
      {
        "slug": "aplasia-hypoplasia-involving-the-nose",
        "name": "Decreased nasal size",
        "genes": 10,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-involving-the-nose"
      },
      {
        "slug": "abnormal-nasal-septum-morphology",
        "name": "Abnormality of septum of nose",
        "genes": 5,
        "url": "https://dantelabs.com/traits/abnormal-nasal-septum-morphology"
      },
      {
        "slug": "abnormal-nostril-morphology",
        "name": "Abnormality of the nostrils",
        "genes": 5,
        "url": "https://dantelabs.com/traits/abnormal-nostril-morphology"
      },
      {
        "slug": "midline-defect-of-the-nose",
        "name": "Midline defect of the nose",
        "genes": 5,
        "url": "https://dantelabs.com/traits/midline-defect-of-the-nose"
      },
      {
        "slug": "slender-nose",
        "name": "Slender nose",
        "genes": 5,
        "url": "https://dantelabs.com/traits/slender-nose"
      },
      {
        "slug": "pear-shaped-nose",
        "name": "Pear-shaped nose",
        "genes": 3,
        "url": "https://dantelabs.com/traits/pear-shaped-nose"
      },
      {
        "slug": "abnormal-nasal-mucosa-morphology",
        "name": "Abnormality of mucosa of nose",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-nasal-mucosa-morphology"
      },
      {
        "slug": "abnormal-nasal-bridge-morphology",
        "name": "Abnormality of the bridge of the nose",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-nasal-bridge-morphology"
      },
      {
        "slug": "abnormal-nasal-cavity-morphology",
        "name": "Abnormal nasal cavity morphology",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-nasal-cavity-morphology"
      },
      {
        "slug": "abnormal-external-nose-morphology",
        "name": "Abnormality of the external nose",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-external-nose-morphology"
      },
      {
        "slug": "pyriform-aperture-stenosis",
        "name": "Pyriform aperture stenosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/pyriform-aperture-stenosis"
      },
      {
        "slug": "abnormal-choanae-morphology",
        "name": "Abnormal choanae morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-choanae-morphology"
      },
      {
        "slug": "abnormal-nasal-base-norphology",
        "name": "Abnormal nasal base",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-nasal-base-norphology"
      },
      {
        "slug": "abnormal-nasal-skeleton-morphology",
        "name": "Abnormality of the nasal skeleton",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-nasal-skeleton-morphology"
      },
      {
        "slug": "fullness-of-paranasal-tissue",
        "name": "Fullness of tissue around the nose",
        "genes": 0,
        "url": "https://dantelabs.com/traits/fullness-of-paranasal-tissue"
      }
    ],
    "genes": [
      {
        "slug": "chuk",
        "symbol": "CHUK",
        "hgnc": "HGNC:1974",
        "name": "component of inhibitor of nuclear factor kappa B kinase complex",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chuk"
      },
      {
        "slug": "cited2",
        "symbol": "CITED2",
        "hgnc": "HGNC:1987",
        "name": "Cbp/p300 interacting transactivator with ED-rich tail 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cited2"
      },
      {
        "slug": "ercc1",
        "symbol": "ERCC1",
        "hgnc": "HGNC:3433",
        "name": "ERCC excision repair 1, endonuclease non-catalytic subunit",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc1"
      },
      {
        "slug": "ercc2",
        "symbol": "ERCC2",
        "hgnc": "HGNC:3434",
        "name": "ERCC excision repair 2, TFIIH core complex helicase subunit",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc2"
      },
      {
        "slug": "ercc5",
        "symbol": "ERCC5",
        "hgnc": "HGNC:3437",
        "name": "ERCC excision repair 5, endonuclease",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc5"
      },
      {
        "slug": "ercc6",
        "symbol": "ERCC6",
        "hgnc": "HGNC:3438",
        "name": "ERCC excision repair 6, chromatin remodeling factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc6"
      },
      {
        "slug": "flt4",
        "symbol": "FLT4",
        "hgnc": "HGNC:3767",
        "name": "fms related receptor tyrosine kinase 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flt4"
      },
      {
        "slug": "gata4",
        "symbol": "GATA4",
        "hgnc": "HGNC:4173",
        "name": "GATA binding protein 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata4"
      },
      {
        "slug": "gata5",
        "symbol": "GATA5",
        "hgnc": "HGNC:15802",
        "name": "GATA binding protein 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata5"
      },
      {
        "slug": "gata6",
        "symbol": "GATA6",
        "hgnc": "HGNC:4174",
        "name": "GATA binding protein 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata6"
      },
      {
        "slug": "gdf1",
        "symbol": "GDF1",
        "hgnc": "HGNC:4214",
        "name": "growth differentiation factor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf1"
      },
      {
        "slug": "gja5",
        "symbol": "GJA5",
        "hgnc": "HGNC:4279",
        "name": "gap junction protein alpha 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja5"
      },
      {
        "slug": "jag1",
        "symbol": "JAG1",
        "hgnc": "HGNC:6188",
        "name": "jagged canonical Notch ligand 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jag1"
      },
      {
        "slug": "kdr",
        "symbol": "KDR",
        "hgnc": "HGNC:6307",
        "name": "kinase insert domain receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdr"
      },
      {
        "slug": "nkx2-5",
        "symbol": "NKX2-5",
        "hgnc": "HGNC:2488",
        "name": "NK2 homeobox 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-5"
      },
      {
        "slug": "nkx2-6",
        "symbol": "NKX2-6",
        "hgnc": "HGNC:32940",
        "name": "NK2 homeobox 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-6"
      },
      {
        "slug": "tbx1",
        "symbol": "TBX1",
        "hgnc": "HGNC:11592",
        "name": "T-box transcription factor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx1"
      },
      {
        "slug": "zfpm2",
        "symbol": "ZFPM2",
        "hgnc": "HGNC:16700",
        "name": "zinc finger protein, FOG family member 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfpm2"
      },
      {
        "slug": "akt3",
        "symbol": "AKT3",
        "hgnc": "HGNC:393",
        "name": "AKT serine/threonine kinase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt3"
      },
      {
        "slug": "ccnd2",
        "symbol": "CCND2",
        "hgnc": "HGNC:1583",
        "name": "cyclin D2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnd2"
      },
      {
        "slug": "fras1",
        "symbol": "FRAS1",
        "hgnc": "HGNC:19185",
        "name": "Fraser extracellular matrix complex subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fras1"
      },
      {
        "slug": "frem2",
        "symbol": "FREM2",
        "hgnc": "HGNC:25396",
        "name": "FRAS1 related extracellular matrix 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/frem2"
      },
      {
        "slug": "grip1",
        "symbol": "GRIP1",
        "hgnc": "HGNC:18708",
        "name": "glutamate receptor interacting protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grip1"
      },
      {
        "slug": "irf6",
        "symbol": "IRF6",
        "hgnc": "HGNC:6121",
        "name": "interferon regulatory factor 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf6"
      },
      {
        "slug": "msx1",
        "symbol": "MSX1",
        "hgnc": "HGNC:7391",
        "name": "msh homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msx1"
      },
      {
        "slug": "nectin1",
        "symbol": "NECTIN1",
        "hgnc": "HGNC:9706",
        "name": "nectin cell adhesion molecule 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nectin1"
      },
      {
        "slug": "pik3r2",
        "symbol": "PIK3R2",
        "hgnc": "HGNC:8980",
        "name": "phosphoinositide-3-kinase regulatory subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3r2"
      },
      {
        "slug": "sf3b4",
        "symbol": "SF3B4",
        "hgnc": "HGNC:10771",
        "name": "splicing factor 3b subunit 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sf3b4"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "ahsg",
        "symbol": "AHSG",
        "hgnc": "HGNC:349",
        "name": "alpha 2-HS glycoprotein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ahsg"
      },
      {
        "slug": "colec10",
        "symbol": "COLEC10",
        "hgnc": "HGNC:2220",
        "name": "collectin subfamily member 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/colec10"
      },
      {
        "slug": "colec11",
        "symbol": "COLEC11",
        "hgnc": "HGNC:17213",
        "name": "collectin subfamily member 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/colec11"
      },
      {
        "slug": "itgb6",
        "symbol": "ITGB6",
        "hgnc": "HGNC:6161",
        "name": "integrin subunit beta 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb6"
      },
      {
        "slug": "lss",
        "symbol": "LSS",
        "hgnc": "HGNC:6708",
        "name": "lanosterol synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lss"
      },
      {
        "slug": "masp1",
        "symbol": "MASP1",
        "hgnc": "HGNC:6901",
        "name": "MBL associated serine protease 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/masp1"
      },
      {
        "slug": "mcoln1",
        "symbol": "MCOLN1",
        "hgnc": "HGNC:13356",
        "name": "mucolipin TRP cation channel 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcoln1"
      },
      {
        "slug": "twist2",
        "symbol": "TWIST2",
        "hgnc": "HGNC:20670",
        "name": "twist family bHLH transcription factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twist2"
      }
    ]
  }
}