{
  "url": "https://dantelabs.com/traits/abnormal-hand-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-hand-morphology",
    "id": "HP:0005922",
    "name": "Abnormal shape of hand",
    "label": "Abnormal hand morphology",
    "definition": "Any structural anomaly of the hand.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-hand",
        "name": "Abnormality of the hand",
        "url": "https://dantelabs.com/traits/abnormality-of-the-hand"
      }
    ],
    "narrower": [
      {
        "slug": "split-hand",
        "name": "Split hand",
        "genes": 64,
        "url": "https://dantelabs.com/traits/split-hand"
      },
      {
        "slug": "abnormal-metacarpal-morphology",
        "name": "Abnormal shape of long bones of hand",
        "genes": 36,
        "url": "https://dantelabs.com/traits/abnormal-metacarpal-morphology"
      },
      {
        "slug": "hand-clenching",
        "name": "Hand clenching",
        "genes": 36,
        "url": "https://dantelabs.com/traits/hand-clenching"
      },
      {
        "slug": "large-hands",
        "name": "Large hands",
        "genes": 33,
        "url": "https://dantelabs.com/traits/large-hands"
      },
      {
        "slug": "autoamputation-of-digits",
        "name": "Autoamputation of digits",
        "genes": 14,
        "url": "https://dantelabs.com/traits/autoamputation-of-digits"
      },
      {
        "slug": "mitten-deformity",
        "name": "Mitten deformity",
        "genes": 9,
        "url": "https://dantelabs.com/traits/mitten-deformity"
      },
      {
        "slug": "ulnar-claw",
        "name": "Ulnar claw",
        "genes": 9,
        "url": "https://dantelabs.com/traits/ulnar-claw"
      },
      {
        "slug": "abnormal-carpal-morphology",
        "name": "Abnormal wrist bones",
        "genes": 8,
        "url": "https://dantelabs.com/traits/abnormal-carpal-morphology"
      },
      {
        "slug": "short-tubular-bones-of-the-hand",
        "name": "Short tubular bones of the hand",
        "genes": 4,
        "url": "https://dantelabs.com/traits/short-tubular-bones-of-the-hand"
      },
      {
        "slug": "abnormal-hand-bone-ossification",
        "name": "Abnormal maturation of the hand bones",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-hand-bone-ossification"
      },
      {
        "slug": "deviation-of-the-hand-or-of-fingers-of-the-hand",
        "name": "Displaced hand or fingers of the hand",
        "genes": 2,
        "url": "https://dantelabs.com/traits/deviation-of-the-hand-or-of-fingers-of-the-hand"
      },
      {
        "slug": "abnormal-hand-metaphysis-morphology",
        "name": "Abnormality of the wide portion of the hand bone",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-hand-metaphysis-morphology"
      },
      {
        "slug": "curved-fingers",
        "name": "Curved fingers",
        "genes": 1,
        "url": "https://dantelabs.com/traits/curved-fingers"
      },
      {
        "slug": "duplication-of-hand-bones",
        "name": "Duplication of hand bones",
        "genes": 1,
        "url": "https://dantelabs.com/traits/duplication-of-hand-bones"
      },
      {
        "slug": "valgus-hand-deformity",
        "name": "Valgus hand deformity",
        "genes": 1,
        "url": "https://dantelabs.com/traits/valgus-hand-deformity"
      },
      {
        "slug": "abnormal-hand-epiphysis-morphology",
        "name": "Abnormality of the end part of the hand bone",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-hand-epiphysis-morphology"
      },
      {
        "slug": "aplasia-hypoplasia-involving-bones-of-the-hand",
        "name": "Absent/small hand bones",
        "genes": 0,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-involving-bones-of-the-hand"
      },
      {
        "slug": "fractured-hand-bones",
        "name": "Fractured hand bones",
        "genes": 0,
        "url": "https://dantelabs.com/traits/fractured-hand-bones"
      },
      {
        "slug": "synostosis-involving-bones-of-the-hand",
        "name": "Fused hand bones",
        "genes": 0,
        "url": "https://dantelabs.com/traits/synostosis-involving-bones-of-the-hand"
      },
      {
        "slug": "osteolytic-defects-of-the-hand-bones",
        "name": "Osteolytic defects of the hand bones",
        "genes": 0,
        "url": "https://dantelabs.com/traits/osteolytic-defects-of-the-hand-bones"
      }
    ],
    "genes": [
      {
        "slug": "mmp14",
        "symbol": "MMP14",
        "hgnc": "HGNC:7160",
        "name": "matrix metallopeptidase 14",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp14"
      },
      {
        "slug": "mmp2",
        "symbol": "MMP2",
        "hgnc": "HGNC:7166",
        "name": "matrix metallopeptidase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp2"
      },
      {
        "slug": "gan",
        "symbol": "GAN",
        "hgnc": "HGNC:4137",
        "name": "gigaxonin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gan"
      },
      {
        "slug": "spart",
        "symbol": "SPART",
        "hgnc": "HGNC:18514",
        "name": "spartin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spart"
      },
      {
        "slug": "ext1",
        "symbol": "EXT1",
        "hgnc": "HGNC:3512",
        "name": "exostosin glycosyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext1"
      },
      {
        "slug": "ext2",
        "symbol": "EXT2",
        "hgnc": "HGNC:3513",
        "name": "exostosin glycosyltransferase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext2"
      },
      {
        "slug": "slc26a2",
        "symbol": "SLC26A2",
        "hgnc": "HGNC:10994",
        "name": "solute carrier family 26 member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a2"
      },
      {
        "slug": "fam50a",
        "symbol": "FAM50A",
        "hgnc": "HGNC:18786",
        "name": "family with sequence similarity 50 member A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam50a"
      }
    ]
  }
}