{
  "url": "https://dantelabs.com/traits/abnormal-dense-granule-content",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-dense-granule-content",
    "id": "HP:0012529",
    "name": "Abnormal dense granule content",
    "definition": "A deviation from the normal contents of the platelet alpha granules, which normally contain adenosine triphosphate (ATP), adenosine diphosphate (ADP), serotonin, calcium, and pyrophosphate, which are secreted when platelets are activated.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-dense-granules",
        "name": "Abnormal dense granules",
        "url": "https://dantelabs.com/traits/abnormal-dense-granules"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "runx1",
        "symbol": "RUNX1",
        "hgnc": "HGNC:10471",
        "name": "RUNX family transcription factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/runx1"
      }
    ]
  }
}