{
  "url": "https://dantelabs.com/traits/abnormal-cornea-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-cornea-morphology",
    "id": "HP:0000481",
    "name": "Abnormal cornea morphology",
    "definition": "Any abnormality of the cornea, which is the transparent tissue at the front of the eye that covers the iris, pupil, and anterior chamber.",
    "synonyms": [
      "Abnormality of the cornea",
      "Corneal abnormalities",
      "Corneal abnormality"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-anterior-eye-segment-morphology",
        "name": "Abnormal anterior eye segment morphology",
        "url": "https://dantelabs.com/traits/abnormal-anterior-eye-segment-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "corneal-opacity",
        "name": "Corneal opacity",
        "genes": 166,
        "url": "https://dantelabs.com/traits/corneal-opacity"
      },
      {
        "slug": "corneal-dystrophy",
        "name": "Corneal dystrophy",
        "genes": 33,
        "url": "https://dantelabs.com/traits/corneal-dystrophy"
      },
      {
        "slug": "corneal-neovascularization",
        "name": "New blood vessel formation in cornea",
        "genes": 27,
        "url": "https://dantelabs.com/traits/corneal-neovascularization"
      },
      {
        "slug": "abnormal-corneal-endothelium-morphology",
        "name": "Abnormal corneal endothelium morphology",
        "genes": 15,
        "url": "https://dantelabs.com/traits/abnormal-corneal-endothelium-morphology"
      },
      {
        "slug": "corneal-perforation",
        "name": "Corneal perforation",
        "genes": 14,
        "url": "https://dantelabs.com/traits/corneal-perforation"
      },
      {
        "slug": "limbal-dermoid",
        "name": "Benign eye tumor",
        "genes": 9,
        "url": "https://dantelabs.com/traits/limbal-dermoid"
      },
      {
        "slug": "abnormal-corneal-limbus-morphology",
        "name": "Abnormal corneal limbus morphology",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-corneal-limbus-morphology"
      },
      {
        "slug": "abnormal-corneal-epithelium-morphology",
        "name": "Abnormal corneal epithelium morphology",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-corneal-epithelium-morphology"
      },
      {
        "slug": "cornea-verticillata",
        "name": "Cornea verticillata",
        "genes": 1,
        "url": "https://dantelabs.com/traits/cornea-verticillata"
      },
      {
        "slug": "corneal-degeneration",
        "name": "Corneal degeneration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/corneal-degeneration"
      },
      {
        "slug": "corneopalpebral-synechiae",
        "name": "Corneopalpebral synechiae",
        "genes": 1,
        "url": "https://dantelabs.com/traits/corneopalpebral-synechiae"
      },
      {
        "slug": "abnormal-corneal-stroma-morphology",
        "name": "Abnormal corneal stroma morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-corneal-stroma-morphology"
      },
      {
        "slug": "abnormal-corneal-thickness",
        "name": "Abnormal corneal thickness",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-corneal-thickness"
      },
      {
        "slug": "abnormal-line-of-schwalbe-morphology",
        "name": "Abnormal line of Schwalbe morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-line-of-schwalbe-morphology"
      },
      {
        "slug": "abnormality-of-corneal-size",
        "name": "Abnormality of corneal size",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormality-of-corneal-size"
      },
      {
        "slug": "abnormality-of-the-curvature-of-the-cornea",
        "name": "Abnormality of the curvature of the cornea",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormality-of-the-curvature-of-the-cornea"
      }
    ],
    "genes": [
      {
        "slug": "ctns",
        "symbol": "CTNS",
        "hgnc": "HGNC:2518",
        "name": "cystinosin, lysosomal cystine transporter",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ctns"
      },
      {
        "slug": "tgfbi",
        "symbol": "TGFBI",
        "hgnc": "HGNC:11771",
        "name": "transforming growth factor beta induced",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfbi"
      },
      {
        "slug": "megf8",
        "symbol": "MEGF8",
        "hgnc": "HGNC:3233",
        "name": "multiple EGF like domains 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/megf8"
      },
      {
        "slug": "rab23",
        "symbol": "RAB23",
        "hgnc": "HGNC:14263",
        "name": "RAB23, member RAS oncogene family",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab23"
      },
      {
        "slug": "col1a1",
        "symbol": "COL1A1",
        "hgnc": "HGNC:2197",
        "name": "collagen type I alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col1a1"
      },
      {
        "slug": "col5a1",
        "symbol": "COL5A1",
        "hgnc": "HGNC:2209",
        "name": "collagen type V alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col5a1"
      },
      {
        "slug": "col5a2",
        "symbol": "COL5A2",
        "hgnc": "HGNC:2210",
        "name": "collagen type V alpha 2 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col5a2"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flna"
      },
      {
        "slug": "lama3",
        "symbol": "LAMA3",
        "hgnc": "HGNC:6483",
        "name": "laminin subunit alpha 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama3"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "hgnc": "HGNC:6490",
        "name": "laminin subunit beta 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb3"
      },
      {
        "slug": "lamc2",
        "symbol": "LAMC2",
        "hgnc": "HGNC:6493",
        "name": "laminin subunit gamma 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamc2"
      },
      {
        "slug": "map3k7",
        "symbol": "MAP3K7",
        "hgnc": "HGNC:6859",
        "name": "mitogen-activated protein kinase kinase kinase 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k7"
      },
      {
        "slug": "dnai1",
        "symbol": "DNAI1",
        "hgnc": "HGNC:2954",
        "name": "dynein axonemal intermediate chain 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnai1"
      },
      {
        "slug": "pitx2",
        "symbol": "PITX2",
        "hgnc": "HGNC:9005",
        "name": "paired like homeodomain 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pitx2"
      },
      {
        "slug": "znf469",
        "symbol": "ZNF469",
        "hgnc": "HGNC:23216",
        "name": "zinc finger protein 469",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf469"
      }
    ]
  }
}