{
  "url": "https://dantelabs.com/traits/abnormal-circulating-renin-concentration",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-renin-concentration",
    "id": "HP:0040084",
    "name": "Abnormal circulating renin",
    "label": "Abnormal circulating renin concentration",
    "definition": "A deviation from the normal concentration of renin in the blood, a central hormone in the control of blood pressure and various other physiological functions.",
    "synonyms": [
      "Abnormal plasma renin"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-renin-angiotensin-system",
        "name": "Abnormality of renin-angiotensin system",
        "url": "https://dantelabs.com/traits/abnormality-of-renin-angiotensin-system"
      }
    ],
    "narrower": [
      {
        "slug": "increased-circulating-renin-concentration",
        "name": "Elevated blood renin level",
        "genes": 19,
        "url": "https://dantelabs.com/traits/increased-circulating-renin-concentration"
      },
      {
        "slug": "decreased-circulating-renin-concentration",
        "name": "Decreased circulating renin concentration",
        "genes": 15,
        "url": "https://dantelabs.com/traits/decreased-circulating-renin-concentration"
      }
    ],
    "genes": [
      {
        "slug": "cacna1d",
        "symbol": "CACNA1D",
        "hgnc": "HGNC:1391",
        "name": "calcium voltage-gated channel subunit alpha1 D",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1d"
      },
      {
        "slug": "kcnj5",
        "symbol": "KCNJ5",
        "hgnc": "HGNC:6266",
        "name": "potassium inwardly rectifying channel subfamily J member 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj5"
      },
      {
        "slug": "clcn2",
        "symbol": "CLCN2",
        "hgnc": "HGNC:2020",
        "name": "chloride voltage-gated channel 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcn2"
      }
    ]
  }
}